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Biomedical subjects

V V Trusov

Publications and source records attributed to V V Trusov.

At least 19 recordsLinked to original sources
PubMed2003

[Clinical significance of assessment of the metabolism of connective-tissue biopolymers in patients with type 1 diabetes mellitus and with diabetic nephropathy].

The purpose of the case study was to define a degree of destructive changes in the connective tissue at different stages of diabetic nephropathy (DN) progression. One hundred and twenty eight DN patients with type 1 diabetes mellitus, disease duration-5 to 20 years (classification according C. Mogensen, 1983) were examined. Special biochemical tools were used to evaluate the connective-tissue condition. The parameters of metabolism of the connective-tissue biopolymers were investigated in blood, urea and saliva, i.e. general and sulphated glucosamine glycine (GAG), sialic acid (SA) and oxyproline fractions. The results showed an increasing value of total and sulphated GAG and SA with a worsening DN severity, which is indicative of a destruction degree of glycoprotein-complexes in the microvascular basal membranes. A high level of bound oxyproline fractions denotes the fibril-genesis processes, which start to activate yet at the preclinical DN stage. The changes detected previously in the parameters of metabolism of the connective-tissue biopolymers, as observed in DN patients, ensure a timely choice of a therapy and a proper monitoring of its efficiency.

Adult↗
PubMed1999

[The joint use of hemosorption and plasmapheresis in the combined treatment of rheumatoid arthritis patients].

AIM: Assessment of hemopheresis effects on calcium-regulating and immune systems, clinical and laboratory activity of rheumatoid arthritis (RA). MATERIALS AND METHODS: Hemosorption and plasmapheresis were included in combined treatment of 86 RA patients. Plasmapheresis was performed 3-5 days after hemosorption (a total of 4-6 procedures per course). The activity of RA, immune and calcium-regulating system were assessed clinically, with laboratory tests, enzyme immunoassay. RESULTS: Hemosorption plus plasmapheresis produced positive effects on the disease course, activity. Laboratory indices improved. Percentage of T-helpers and T-suppressors, calcitonin loading rate, levels of parathormone, calcidiol normalized. CONCLUSION: Combined hemopheresis therapy promotes correction of disorders in immune and calcium-regulating systems.

Adult↗
PubMed1996

[The characteristics of disorders in carbohydrate metabolism and insulin and C-peptide secretion in patients with chronic glomerulonephritis in developing chronic kidney failure].

The authors studied hormonal regulation of carbohydrate metabolism by secretion of insulin, C-peptide in 86 patients with chronic glomerulonephritis with different functional condition of the kidneys. There was a decrease in glucose tolerance, basal and reactive hyperinsulinemia, elevated level of C-peptide (relative insulin insufficiency). Mechanism of arising changes in the carbohydrate and insulin metabolism is complex and multicomponent. This includes renal lesion and consequent inhibition of hormone metabolism. Intensification of glomerular filtration is associated with inhibition of filtration of insulin and C-peptide derivants. Accumulation of nitrogen metabolism products results in changed response of pancreatic beta-cells to glucose. General disturbances of metabolism are accompanied by increasing levels of hormonal and nonhormonal contrainsular substances.

Adolescent↗
PubMed1995

[The effect of hemosorption and plasmapheresis on fibrinogen-125I kinetics in patients with rheumatoid arthritis].

125I-labelled fibrinogen kinetics has been studied in 73 patients with rheumatoid arthritis (RA). Of them, 53 subjects underwent hemosorptions or hemosorptions combined with plasmapheresis. Fibrinogen metabolism in RA patients appeared enhanced versus healthy controls. It was observed that hemosorption treatment or its combination with plasmapheresis produce positive changes in clinical and laboratory RA parameters, improve fibrinogen metabolism. The study of fibrinogen kinetics is useful in assessing efficacy of on-going treatment.

Adult↗
PubMed1992

[Effects of hemosorption on the regulation of calcium metabolism in patients with rheumatoid arthritis].

A clinical response to hemosorption and the alterations in the calcium regulatory systems associated with the treatment mentioned were studied in 42 patients with rheumatoid arthritis. The use of hemosorption in the multiple modality treatment resulted in a manifest clinical and laboratory positive effect featured by the improvement of the general condition of the patient, a decrease in the values of the joint syndrome and the activity of the inflammatory processes as it was evidenced by routine laboratory tests and the time-course of the contents of beta 2-microglobulin in the blood and synovial fluid. Hemosorption helped the correction of the performance of the systems of calcium regulation: a decrease in parathyrin contents, an increase in the contents of calcidiol, osteocalcin, and ionized calcium.

Adult↗
PubMed1991

[Anti-reflux biliary-digestive anastomosis including the gallbladder in the light of long-term results].

The authors provide the long-term results of cholecysto-digestive + anastomoses in 59 patients operated on for nontumorous diseases. The gallbladder anastomosed with the upper parts of the alimentary tract preserved reservoir and concentration functions, ability for visualization during cholecystocholangiography. The discrete pulse mechanism of bile secretion via the bile diverting anastomoses and their antireflux function eliminated the risk of chronic pancreatitis and terminal cholangitis. The recovery of deranged liver functions and excretory functions of the pancreas were traced during the postoperative period within 2 to 21 years.

Adult↗
PubMed1991

[The effect of plasmapheresis on the function of the calcium-regulating systems in patients with rheumatoid arthritis].

As many as 87 patients with rheumatoid arthritis were examined for changes in the status of the calcium-regulating systems under the influence of therapy. The multimodality treatment of 57 of the patients included discrete plasmapheresis, which allowed the attainment of an earlier and more marked beneficial clinicolaboratory effect. Plasmapheresis contributed to the correction of the status of the calcium-regulating systems: to a decrease of the level of parathyrin, an increase of the concentration of calcitonin, calcidiol, total and ionized calcium.

Adult↗
PubMed1990

[Possibilities of hemosorption in the compensation of cardiac dysfunction in patients with ischemic heart disease associated with diabetes mellitus].

A total of 36 patients with unstable angina and type II diabetes mellitus were studied in the dynamic. All the patients underwent extracorporeal hemocarboperfusion. Marked improvement in the inotropic function of the myocardium was noted with the increase in the rate of relaxation and contraction of the posterior wall of the myocardium. A decrease in the pressure in the lesser circulation and specific peripheral resistance were registered. Using radiometry technique a corresponding decrease in the volume of extravascular fluid in the lungs was observed.

Adult↗
PubMed1989

[Diagnostic significance of calcitonin analysis in children with rickets and rickets-like diseases administered calcium test].

The secretory activity of C-cells of the thyroid was investigated in 25 children with rickets and rickets-like diseases. There were 13 children with grades II and III rickets, 6 with vitamin D-dependent rickets, and 6 with Debre-de Toni-Fanconi disease. Five normal children constituted a control group. The basal concentration of calcitonin did not differ from the control parameter in all patients' groups. An increased release of the hormone to the blood was noticed in response to calcium stimulation. The rise of blood calcitonin was determined by the disease pattern, which made it possible to use the test with a one-minute intravenous calcium injection for differential diagnosis purposes. The maximal changes were discovered in children suffering from vitamin D-dependent rickets.

Calcitonin↗