Biomedical subjects

W A Zorn

Publications and source records attributed to W A Zorn.

5 recordsLinked to original sources

PubMed1992

Parents' developmental perceptions and expectations for their high-risk infants.

This study examines the relationship between developmental outcomes of high-risk infants and parental perceptions and expectations. Parents of 209 consecutive high-risk infants were asked to provide their development interpretations and expectations before their infants received standard developmental assessments between April and October 1989. Moderate correlations between parents and professional assessments of motor and language skills were noted (p less than .05 to p less than .01). Most agreements occurred when infants were assessed as normal by professionals. Disagreements were common and occurred in all areas of development. These mismatches were not associated with gestational age at birth, neonatal complications, poverty, or estimates of parental experience. Professionals should take seriously any expressed developmental concerns by parents of high-risk infants. Expressed developmental concerns, however, cannot be relied on for developmental screening of high-risk infants.

Attitude↗

PubMed1991

Risk factors for major neurodevelopmental impairments and need for special education resources in extremely premature infants.

The purpose of this cohort study was to determine the incidence of and risk factors for major neurodevelopmental impairments among survivors of extreme prematurity. The study cohort comprised 100 infants born between 24 and 28 weeks of gestational age at one tertiary center from 1983 to 1984. Twenty-five infants (25%) died; 75 (75%) survived until follow-up (mean, 60 months). Standardized neurodevelopmental and psychometric assessments were performed in blind fashion on 68 of the 75 surviving children (91% follow-up). Informal assessments (parent, teacher, and physician reports) were obtained instead for seven (9%) children who had relocated outside of the area. Overall, 19 children (25%) had one or more major impairments: mental retardation, 9; cerebral palsy, 4; multiple impairments, 5; and blindness, 1. Despite a high prevalence of impairments, 95% of children (n = 71) were functionally independent [corrected]. Special educational resources were definitely necessary for seven (9%) and possibly needed for 36 (48%) additional children. Univariate analyses revealed four significant risk factors for cerebral palsy: hydrocephalus (relative risk = 12.2), grades III and IV intraventricular hemorrhage (relative risk = 5.8), 5-minute Apgar score lower than 7 (relative risk = 5.7), and bronchopulmonary dysplasia (relative risk = 5.5). Hydrocephalus was the only significant risk factor observed for mental retardation (relative risk = 5.4). Risk factors predicting a need for special education resources included sepsis (relative risk = 24.9), low socioeconomic status (relative risk = 16.3), and nonwhite race (relative risk = 3.0). Thus our data suggest that biomedical factors appear to confer the greatest risk of major impairments; sociodemographic factors appear to have a significant impact on educational risk in extremely premature infants who do not die. Continued follow-up with biomedical and developmental-social interventions appears warranted to decrease the risk of educational underachievement in this population.

Birth Weight↗

PubMed1986

Preterm very-low-birth-weight neonates: relationship of EEG to intracranial hemorrhage, perinatal complications, and developmental outcome.

EEGs were performed on 102 preterm low-birth-weight neonates within the first 7 days of life. Babies were later separated into those without intracranial hemorrhage, those who had only subependymal hemorrhage (SEH), and those with intraventricular/intracerebral hemorrhage. The incidence and types of EEG abnormalities, 42% overall and including positive rolandic sharp waves, did not differ in the three groups. The incidence and distribution of EEG abnormalities between groups were not influenced by perinatal events. Developmental follow-up of 73 patients was similarly not correlated with neonatal EEG results, although the most severe EEG abnormalities were associated with subsequent mortality or morbidity.

Cerebral Hemorrhage↗

PubMed1984

Mortality and follow-up data for neonates weighing 500 to 800 g at birth.

Survival and development of immature premature neonates (birth weight, less than or equal to 800 g) at a single regional center were compared for 2 1/2 years, when such neonates' conditions were considered hopeless, and for the next 4 1/2 years, when aggressive therapy was used. During the first 2 1/2 years, two (4%) of 56 survived, one of whom was profoundly impaired. During the next 4 1/2 years, 65 (44%) of 147 survived. Of 65 survivors, 54 were followed up for at least one year: 43% were normal, 22% had mild developmental delays, and 19 (35%) were impaired. Of the 19 impaired, one was profoundly impaired and four were severely affected. The number of normal survivors and the high level of functioning of most of the impaired survivors suggests intensive care is as appropriate for neonates weighing 800 g or less as for more mature, severely ill newborns

Birth Weight↗

PubMedDate not supplied

Multivariate risks among extremely premature infants.

This study was designed to identify risk factors for mortality and morbidity of extremely premature infants born in the surfactant era. The study cohort included 194 infants born at < 29 weeks' gestation at one regional tertiary center between 1983 and 1986. Forty-one infants died. Blinded neurodevelopmental assessments were performed on 149 of 153 (97%) survivors at a mean age of 52 months. Thirty-one (21%) survivors had major impairments: 15 had mental retardation, 8 had multiple impairments, 7 had cerebral palsy, and 1 was blind. Logistic regression analysis identifies five significant risk factors for mortality: grade III or IV intraventricular hemorrhage, birth weight < 800 gm, 5-minute Apgar score < or = 3, male sex, and absence of surfactant therapy. Significant risk factors for any major impairment included sepsis (relative risks [RR] = 6.4), male sex (RR = 3.1), and nonwhite race (RR = 2.8). Hydrocephalus requiring shunting was a significant risk factor for cerebral palsy (RR = 16.4) and neonatal retardation (RR = 16.0). Nonwhite race (RR = 7.3), sepsis (RR = 6.8), and male sex (RR = 3.7) also were significant risk factors for mental retardation. Confirmation of these risk factors should facilitate development of targeted interventions for optimizing long-term outcome.

Blindness↗