Multivariate risks among extremely premature infants.

M E Msall; G M Buck; B T Rogers; D P Merke; C C Wan; N L Catanzaro; W A Zorn

PubMed · 8169677

Multivariate risks among extremely premature infants.

M E Msall·G M Buck·B T Rogers·D P Merke·C C Wan·N L Catanzaro·W A Zorn

Abstract

This study was designed to identify risk factors for mortality and morbidity of extremely premature infants born in the surfactant era. The study cohort included 194 infants born at < 29 weeks' gestation at one regional tertiary center between 1983 and 1986. Forty-one infants died. Blinded neurodevelopmental assessments were performed on 149 of 153 (97%) survivors at a mean age of 52 months. Thirty-one (21%) survivors had major impairments: 15 had mental retardation, 8 had multiple impairments, 7 had cerebral palsy, and 1 was blind. Logistic regression analysis identifies five significant risk factors for mortality: grade III or IV intraventricular hemorrhage, birth weight < 800 gm, 5-minute Apgar score < or = 3, male sex, and absence of surfactant therapy. Significant risk factors for any major impairment included sepsis (relative risks [RR] = 6.4), male sex (RR = 3.1), and nonwhite race (RR = 2.8). Hydrocephalus requiring shunting was a significant risk factor for cerebral palsy (RR = 16.4) and neonatal retardation (RR = 16.0). Nonwhite race (RR = 7.3), sepsis (RR = 6.8), and male sex (RR = 3.7) also were significant risk factors for mental retardation. Confirmation of these risk factors should facilitate development of targeted interventions for optimizing long-term outcome.

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Blindness Cerebral Palsy Child Development Cohort Studies Female Follow-Up Studies Gestational Age Humans Infant Mortality Infant, Newborn Infant, Premature Intellectual Disability Male Nervous System Diseases Pulmonary Surfactants Regression Analysis Risk Factors Journal Article Research Support, Non-U.S. Gov't

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M E Msall, G M Buck, B T Rogers, D P Merke, C C Wan, N L Catanzaro, W A Zorn. Multivariate risks among extremely premature infants.. https://pubmed.ncbi.nlm.nih.gov/8169677/

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