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Biomedical subjects

W Dölle

Publications and source records attributed to W Dölle.

At least 37 records · Page 2Linked to original sources
PubMed1985

Serum inhibitory factors (SIF) are of prognostic value in acute viral hepatitis.

Serum inhibitory factors (SIF) were analysed in relation to the natural course of acute viral hepatitis in 81 patients followed over a period of 1 year. 63 patients recovered completely (group 1), and 18 had a protracted course of hepatitis (group 2) as shown by persistent transaminase activity 6 months after onset. 11 patients in group 2 still had signs of liver disease after 1 year. A gradual fall of SIF activity (in 47 patients) heralded resolving hepatitis, whereas persistence of SIF (in 8 patients) correlated with inflammatory activity and failure of hepatitis B viral antigen elimination. Absence of SIF activity was associated with either an uncomplicated or a chronic course of hepatitis in 23 and 3 patients, respectively. Repeated determination of SIF may help to predict the final outcome of hepatitis. Both excessive and failure of SIF production may result in the development of chronic liver disease.

Acute Disease↗
PubMed1982

[Liver damage caused by drugs].

Drug injury of the liver presents as I. functional disorder without jaundice; 2. predominant cholostatic disease; 3. predominant hepatitic disease; 4. a combination of 2 und 3.--A predictable dose related direct toxic injury can be differentiated from an unpredictable dose independent indirect injury mostly of the hypersensitivity type. Special varieties are severe fatty liver, peliosis, Budd-Chiari-Syndrome, liver tumors and granulomas. The diagnosis can be proven by reexposition or better--by the in vitro lymphocyte stimulation test. --There is no specific treatment apart from stopping the responsible drug. Prognosis is good but in some cases a chronic course develops presenting as chronic aggressive hepatitis or cirrhosis.

Budd-Chiari Syndrome↗
PubMed1981

Latent portasystemic encephalopathy. I. Nature of cerebral functional defects and their effect on fitness to drive.

Forty patients with chronic liver disease and portal hypertension but without clinical signs of portasystemic encephalopathy (15 patients with nonalcoholic cirrhosis, 15 patients with alcoholic cirrhosis, and 10 patients with minimal EEG changes) and a control group of 12 patients with chronic alcohol pancreatitis were studied using an extensive psychometric program, which, in the same form, is used for expert reports on driving capacity. Of the cirrhotic patients, 60% were considered unfit to drive; in 25% driving capacity was questionable, 15% (only nonalcoholic cirrhotics) were considered fit to drive. In contrast 75% of the patients with alcoholic pancreatitis were considered fit to drive. Major defects were found only in three heavy alcoholics. Patients with alcoholic cirrhosis scored lower than patients with nonalcoholic cirrhosis. This was due to differences in liver function rather than to the effect of alcohol consumption. Patients with minimal EEG changes were practically all considered unfit to drive.

Adult↗
PubMed1981

[Irritable colon].

Explore the source record for details and available documents.

Colonic Diseases, Functional↗
PubMed1980

[Epidemiology and clinical aspects of non-A, non-B hepatitis (author's transl)].

Among 288 patients with acute viral hepatitis investigated between 1970 and 1976 29 (10%) had non-A, non-B hepatitis. In 9 of these 29 patients posttransfusion hepatitis was proven, the remaining 20 patients had sporadic infections. The incubation period of posttransfusion hepatitis was 2--8 weeks in 7 patients and 12 and 16 weeks in the two other patients. Transaminases changed monophasically in 22 patients, bi- or multiphasic in 7. The disease took a subicteric course in a quarter of all cases. Out of the 29 patients 17 were followed up for 2 to 7 years, one or more recurrence occurred in 9 patients, usually within the first two years after onset of the disease. Five of these 9 patients had a biphasic rise of transaminases during the acute stage. The almost complete absence of autoantibodies in the course of the acute phase might be evidence of increased suppressor cell activity favouring a chronic course. Non-organ-specific autoantibodies were only rarely observed and were completely absent in patients with posttransfusion hepatitis.

Acute Disease↗