PubMed Health⌕ Search

Biomedical subjects

W Distler

Publications and source records attributed to W Distler.

At least 37 records · Page 2Linked to original sources
PubMed1992

[Dexamethasone does not normalize disordered LH pulsatility in hyperandrogenemic ovarian insufficiency].

Application of dexamethasone (DEX) is well accepted for treatment of hyperandrogenemic ovarian failure (HOI). In some cases of clomiphene resistance, additional DEX can induce ovulatory cycles. In this study, we evaluated the influence of adrenal androgen reduction on the gonadotroph during longterm therapy with 0.5 mg DEX daily in a larger group of patients (n = 25) in order to investigate subgroups of HOI. Women with elevated DHEA-sulfate levels only (DS-group); with elevated testosterone and/or androstenedione levels only (TA); with polycystic ovaries in ultrasound (PCO), with highest LH levels (LH); with secondary amenorrhea (SA); with oligomenorrhea (OL) and with elevated body mass index (BMI) were included. Blood samples were taken at 10 min intervals for 12 h sampling periods (8am-8pm) and analyzed by RIA. In amenorrhoeic patients, investigations took place at monthly intervals; in cycling women preferentially on day 5 of the cycle. LH and FSH profiles were evaluated by 3 different computerized peak identification programs ("pulsar", "ultra" and "modified Santen and Bardin"). DEX resulted in significant decreases in T, A, DS and progesterone serum levels in all subgroups. No significant alterations were found in estradiol levels and only small variations in few subgroups with estrone. Mean LH concentrations exhibited small decreases (p less than 0.05) in DS-, LH- and OL subgroups and no changes in the others. With the exception of a decrease in "pulsar" pulse frequency in the OL subgroup, no changes in pulse frequency or amplitude were found in any other group during DEX therapy. Mean FSH concentrations and pulsatility did not vary either.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1990

[Cultural and serologic Chlamydia detection in diagnosis of sterility and increased risk of infection].

364 women were studied for the possible role of chlamydia trachomatis infection as a factor related to infertility. C. trachomatis was isolated from the cervix in 20% of our high-risk STD patients and in a much lower proportion in patients with tubal (5%) or unexplained (4%) infertility. IgG-antibodies to C. trachomatis were found in 75% of patients with tubal infertility, in 44% of women without gynaecological diseases and in 87% of the high-risk STD patients. By contrast, the difference was significant in the IgA-antibody tests. 67% of the women with tubal infertility and only 25% of the women with nontubal infertility were positive. From these data it appears, that antecedent infections with C. trachomatis, as measured by antibody prevalence, are an important factor in infertility of tubal origin.

Bacteriological Techniques↗
PubMed1990

[The value of functional tests in diagnosis of prolactinoma].

The present study in 37 hyperprolactinaemic patients was performed, to investigate the relationship between radiographic changes of the pituitary region and serum prolactin levels, clinical signs and the results of dynamic tests. Prolactin responsiveness after metoclopramide- and TRH-injection and the nocturnal profile of serum prolactin were examined in 25 women. The results of the dynamic tests did not correlate with the radiological diagnosis. However, serum prolactin concentrations correlated strongly with the radiographic evidence of a pituitary tumour. The results show, that prolactin stimulation tests and the evaluation of the nocturnal secretory pattern of prolactin are not useful for differentiating between adenoma and nonadenoma caused hyperprolactinaemia. However, determinations of prolactin serum levels are of great clinical importance in the diagnosis of prolactinomas.

Circadian Rhythm↗
PubMed1989

[Immunologically-induced abortion--diagnosis and therapy].

As etiological factors responsible for repeated miscarriages disturbances of the maternal-fetal immunoregulation are involved. Diagnostic aspects of the immunobiology of abortion and the clinical management of habitual abortion by immunotherapy are discussed.

Abortion, Habitual↗
PubMed1989

[The climacteric--physiology or pathology?].

Nearly 30 years of a woman's life is spent after cessation of the reproductive function and about 30% of the female population in Europe is postmenopausal. The medical infirmities resulting from estrogen deprivation among postmenopausal women take a high toll. The greatest number of hip fractures because of osteoporosis occur in this group, resulting in a high death (20%-30%) and morbidity rate. Estrogen deprivation leads to a change of the lipid metabolism with acceleration of arteriosclerosis. While the "estrogen forever" era closed with a striking rise in the incidence of adenocarcinoma of the endometrium, combined estrogen-gestagen treatment drastically decreases the incidence of endometrial and breast carcinoma. Therefore, physicians must be aware of the benefits of estrogen-gestagen treatment and act appropriately.

Climacteric↗
PubMed1989

[Diurnal beta-endorphin rhythm in relation to menstrual cycle phase].

Beta-endorphin (beta-EP) concentrations in hypophyseal portal blood are related to the menstrual cycle in primates. In women, changes in peripheral plasma beta-EP-concentrations were detected throughout the menstrual cycle. A similar circadian rhythm of beta-EP and ACTH was observed in males, suggesting a common mechanism of secretion at the pituitary level. We examined beta-EP, cortisol (F) and prolactin (PRL) levels in peripheral blood of regularly menstruating women. Samples were taken every 2 hours between 6 p.m. and 10 a.m. on days 3 and 4 of the menstrual cycle and 6 and 7 days after the rise of the basal body temperature. A diurnal rhythm of beta-EP could be seen between 6 p.m. and 10 a.m. in the luteal phase, but not in the follicular phase. An early morning rise of beta-EP was accompanied by increasing F-concentrations, suggesting a concomitant secretion of beta-EP and ACTH by the cells of the anterior pituitary. We therefore conclude, that ovarian steroids may influence beta-EP secretion at the pituitary level as well.

Adult↗
PubMed1989

Lactate influx and efflux in the 'Streptococcus mutants group' and Streptococcus sanguis.

Lactate influx was measured in Streptococcus sanguis and in several strains of Streptococcus mutans by comparing the intra- and extracellular distribution of (14C)-lactate. Lactate efflux was followed enzymatically against rising external lactate concentration. The glucose concentration was monitored in the same way. With S. sanguis OMZ 9, lactate was transported into the cells when a high external lactate concentration and a pH gradient were established. The transport rate was approximately 1,000 nmol lactate per minute and milligram protein. No lactate influx could be measured with four strains of the 'S. mutans group' (OMZ 51, 634, T3/13 and NCTC 10449). Metabolizing cells of S. mutans NCTC 10449 were able to transport lactate even against an external lactate concentration of 92 mmol/l at pH = 7. The transport rates ranged from 1,200 to 750 nmol lactate/min mg protein decreasing with increasing external lactate concentration. While an external pH = 9 had little influence on transport, transport rates decreased to 440 nmol/min mg protein at pH = 5.

Biological Transport↗