Biomedical subjects

W Distler

Publications and source records attributed to W Distler.

80 records · Page 5Linked to original sources

PubMedDate not supplied

Chemiluminometric determination of tissue polypeptide antigen (TPA), cancer antigen 15-3 (CA 15-3), carcinoembryonic antigen (CEA) in comparison with vascular endothelial growth factor (VEGF) in follow-up of breast cancer.

Vascular endothelial growth factor (VEGF), tissue polypeptide antigen (TPA), cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA) were measured in 314 sera of breast cancer patients and in 58 sera of women without breast cancer. VEGF was determined using a sandwich enzyme immunoassay technique (ELISA) and the tumour markers TPA, CA 15-3 and CEA with an immunoluminometric assay (ILMA). The breast cancer patients were staged according to the TNM classification stages 0-IV (by UICC) in patient groups with a compatible prognosis. Median and range of each stage were investigated. The cut-off values (95th and 97.5th percentile of control group) of VEGF, TPA, CA15-3 and CEA were determined; sensitivities for each parameter and for all combinations of two parameters were investigated for these cut-offs and the receiver operating characteristic (ROC) curves were calculated. The differences between the control group and stages 0-3 were shown to be non-significant for CA 15-3 and CEA but significant for VEGF and TPA. Significant differences were found in stage 4 for VEGF and all three markers. The increase in sensitivity of VEGF from stage 0 to stage 3 and the decrease from stage 3 to stage 4 can be interpreted based on the role of VEGF in the angiogenesis. The quantification of VEGF could give additional information for selecting patients for systemic adjuvant therapy.

Adult↗

PubMedDate not supplied

[The immunologically-caused early abortion].

Recent advances in the understanding of immunological events during pregnancy offer new diagnostic and therapeutic approaches to couples suffering from unexplained recurrent spontaneous abortion. In terms of immunology the success of pregnancy means, that the fetus as a semi-allogeneic graft is not rejected by the mothers/recipients immune system. Beside a variety of specific and non-specific mainly locally acting substances a process of active tolerance induction is responsible for fetal survival. In response to paternally inherited fetal antigens the maternal immune system produces so-called blocking factors. In most women with unexplained recurrent spontaneous abortion these blocking factors cannot be detected. By immunization with paternal or third party lymphocytes the maternal immune system can be stimulated to produce blocking factors and therefore to protect a conceptus from rejection.

Abortion, Habitual↗

PubMedDate not supplied

[Peripartal monitoring of an HTLV III-infected, heroin-dependent pregnant patient].

In the past the acquired immune deficiency syndrome (AIDS) could be mainly observed in homosexual and drug addicted persons. But at present one has to deal with this problem in obstetrics as well. In this paper a report is given on the late pregnancy and delivery in a heroin addicted gravida with positive HTLV III antibodies. We describe the useful tests to characterize the immunologic status of the patient and give recommendations for the clinical management of pregnancy and delivery.

Acquired Immunodeficiency Syndrome↗

PubMedDate not supplied

[AIDS in a child with a LAV/HTLV-III infected mother].

The clinical course of AIDS in a child of a HTLV III virus infected drug addicted mother is reported. Aged 7 month the baby died from Pneumocystis carinii pneumonia. The clinical course prior to the final lethal infection was remarkably uneventful. Immunological controls revealed strikingly high immunoglobulin values, whereas only minor changes of cellular immunity were observed. At birth the baby had HTLV III antibodies as her mother, which dropped during the course of the disease to borderline values.

Acquired Immunodeficiency Syndrome↗

PubMedDate not supplied

[Estriol reaction test for the diagnosis of fetal distress in the 3d trimester].

In order to perform the estriol reaction test, venous blood samples for two basal estriol values were drawn at 7.30 and 8.00 a.m. from each patient. Subsequently all gravidas received 4 mg dexamethasone i.v. Blood was drawn again 4, 8, 24, 28 and 32 h thereafter for determination of unconjugated serum estriol. The analysis of the estriol response curves in 101 patients revealed that the estriol reaction test is helpful to indicate fetoplacental impairment in pregnancies at risk.

Adult↗

PubMedDate not supplied

[Placental morphometric parameters correlated with serum estriol].

In 50 pregnancies morphometric parameters of the placenta and the serum estriol values in the third trimester were correlated. The results show that there is no correlation between the placental parameters as determined by a semi-automatic method and the estriol values in maternal serum in late pregnancy. The placental parameters probably do not reflect the biochemical activity of the trophoblast. A sufficient capacity of the placenta for estriol synthesis must be taken into account independently of its morphological substrate.

Adolescent↗

PubMedDate not supplied

[Critical analysis of fetal risk recognition by serum estriol determination].

In 901 pregnancies between 1978-1981 a total of 5281 serum estriol determinations were performed. 596 gravidas were high-risk patients (diabetes mell., toxemia, IUGR, premature labour, prolonged pregnancy, Rh incompatibility). In 142 of these high-risk pregnancies the estriol values were below the 10th percentile or the estriol decrease extended 40%. These cases were analysed individually, in order to answer the question, how often serum estriol values were decisive for active obstetrical management. Our data show that a drop of estriol over 40% was very rare (0.53%). For the newborn such an estriol-drop does not mean higher perinatal morbidity or mortality in any case. The endocrine parameters were not very often decisive for an active obstetrical intervention. Probably because of the large fluctuations and day-to-day-variations of the estriol values mainly due to drugs which were widely used in risk pregnancies. These exogenous factors had a negative effect on the clinical value of the serum estriol determinations.

Estriol↗

PubMedDate not supplied

[Administration of pethidine in labor with meconium contaminated amniotic fluid: effect on fetal outcome and respiratory disorders].

OBJECTIVE: The aim of the study was to evaluate the effects of maternal pethidine administration on fetal outcome and incidence of neonatal respiratory distress in deliveries with meconium stained amniotic fluid (MAF). STUDY DESIGN: Between 1989 and 1992, 849 live infants had MAF. For pain relief during labor 214 women received pethidine 50-150 mg i.m. The control group included 401 infants with MAF, who were not exposed to sedatives, analgesics, and anesthetics during labor. Fetal cord pH, Apgar 1 min (A1), Apgar 5 min (A5), and incidence of respiratory distress were compared retrospectively between the groups. Statistics and calculations were done by means of uni- and multivariate analyses. RESULTS: The presence of thickened MAF increased significantly the risk of low A1, low A5, low arterial cord pH, and the incidence of respiratory distress (p = 0.003, = 0.0003, = 0.016, = 0.000). Infants with thickened MAF, low A1, and low fetal cord pH proved to have an exceedingly high risk of respiratory distress. The application of pethidine (0 mg, 50 mg, 100-150 mg) does not discriminate the variables as arterial cord pH, A1, A5, and the incidence of respiratory distress significantly. However the medium cord pH values of infants without pethidine (7.27, s = 0.075) and with 100-150 mg pethidine (7.25, s = 0.078) were significantly different (p = 0.0006). The incidence of arterial pH, 7.10 did not differ significantly in cases with different pethidine doses. CONCLUSIONS: Thickened MAF is an obstetric hazard with small but significantly increased risks for poor fetal outcome and neonatal respiratory distress. This study failed to identify additional neonatal risks engendered by use of pethidine in cases of MAF.

Adult↗