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Biomedical subjects

W Friedmann

Publications and source records attributed to W Friedmann.

43 records · Page 3Linked to original sources
PubMed1984

[Quantification of myocardial perfusion defects using 2-dimensional contrast echocardiography].

Ten closed-chested beagles were employed to determine whether reproducible echocontrast imaging of the myocardium could be obtained following injection of the new ultrasonic contrast medium Echocon into the aortic root, and whether myocardial perfusion defects could be successfully diagnosed by this method. The change in intensity of contrast in the myocardium was measured by videodensitometry simultaneously in the supply areas of the left anterior descending and left circumflex branches of the left coronary artery before and during occlusion of the circumflex branch by means of a balloon catheter. Injection of Echocon into the aortic root led to reproducible echocontrast imaging of the entire myocardium. The occlusion of the circumflex branch caused a significant reduction (p less than 0.01) in intensity of contrast in the supply area of the circumflex branch, whereas no differences by comparison with the starting values were identifiable in the supply area of the left anterior descending branch. The correlation factor between the sizes of the perfusion defects ascertained by echocardiography and by planimetric measurement using a pathological anatomical approach was found to be r = 0.89. The injection of Echocon into the aortic root did not induce any significant changes in the aortic or pulmonary pressure, or in heart rate. Only slight flattening of the T-waves, which never lasted longer than 15 seconds, was observed in 50% of the animals. Contrast echocardiography of the myocardium could thus contribute to the diagnosis of coronary heart disease, i.e. perfusion defects.

Animals↗
PubMedDate not supplied

[Immunohistochemical localization of human chorionic gonadotropin and human placental lactogen in placentas of various ages].

By means of the peroxidase-anti-peroxidase reaction it was possible to identify HCG and HPL in placentas between the 6th and 40th weeks in the syncytiotrophoblast, though not in the cytotrophoblast, the villous stroma or in vascular endothelia. A cytophotometric extinction measurement at 425 nm revealed a strong reaction intensity for HCG during the first trimester, a reduction to half this value in the second and further reduction in term placentas. In the 6th and 10th weeks of pregnancy only low quantities of HPL were demonstrable; the amount increased in the second trimester, attaining a maximum in the 24th week. In the third trimester the reaction intensity also decreased for HPL. Irrespective of the gestational age the identification decreased in the syncytiotrophoblast for both hormones in the following order; proliferation buds, necleated portions of epithelium, non-nucleated epithelial squamae, syncytiocapillary membranes, epithelium in cases with fibrosis of the villous stroma, epithelial nodes with nuclear pyknosis.

Chorionic Gonadotropin↗
PubMedDate not supplied

[Fetal oxygen saturation in suspected hypoxia and the normal cardiotocogram (CTG). A prospective study for validating pulse oximetry in the fetus].

During a clinical study 70 women in labour were monitored with fetal pulse oximetry. The oxisensor (FS 10) was positioned between fetal cheek and the uterine wall at a cervical dilatation of 2 cm or more. The advantage of the method is its minimal invasive character and the continuous monitoring of oxygen saturation. The pulse oximeter (N 400, Nellcor) had been blinded for the investigation following criteria met by FDA, so that the investigator could not read the saturation values. Preliminary results of more than 120 hours of monitoring intervals of 10 seconds show the following saturation values (median): 55% under normal CTG (10. perc. 36%, 90. perc. 73%), 42% during episodes of variable decelerations (10. perc. 22%, 90. perc. 63%), 53% during episodes of early decelerations (10. perc. 39%, 90. perc. 74%). Due to pathological fetal heart rate patterns 42 fetal blood analysis were performed. Because of these spectrophotometric saturation measurements (ABL 330, OSM 3, Radiometer) the deviation of the two methods could be calculated. The values of pulse oximetry were 5% higher than those of spectrophotometry. Correlation of both methods was r = 0.64.

Adult↗
PubMedDate not supplied

[Lactate and glucose determination using biosensors in umbilical cord blood].

Postpartal determination of lactate and glucose in the umbilical cord whole blood of 139 successive deliveries utilizing biosensors (blood gas analysator 865, Ciba Corning) are presented. The median lactate value in the umbilical arterial blood is 4.45 mmol/l and in the venous blood 4.23 mmol/l. Following categorization into control and high-risk groups, the arterial mean values are 4.23 mmol/l and 6.39 mmol/l and the respective venous values are 3.95 mmol/l and 5.04 mmol/l. Using the U-test these differences between the control and high-risk groups are significant. The mean of the measured lactate correlates significantly with the mean of the calculated base excess (< 0.001). The mean glucose value in the umbilical arterial blood is 78 mg/dl and in the venous 93 mg/dl. Between high-risk and control group no significant difference is found.

Asphyxia Neonatorum↗