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Biomedical subjects

W G Luttge

Publications and source records attributed to W G Luttge.

71 records · Page 4Linked to original sources
PubMed1970

P-chlorophenylalanine methyl ester: an aphrodisiac?

P-Chlorophenylalanine methyl ester and the ester plus pargyline have been reported to facilitate sexual mounting behavior in animals, but these studies have shown only a facilitation of homosexual mounting. The present study indicates that these agents do not enhance the probability or frequency of heterosexual interactions in rats.

Animals↗
PubMedDate not supplied

Differential up- and down-regulation of type I and type II receptors for adrenocorticosteroid hormones in mouse brain.

Adult female mice were adrenalectomized and ovariectomized and the concentration of Type I and Type II receptors in whole brain, kidney, and liver cytosol determined at various time thereafter by incubation with [3H]aldosterone (+ RU 26988 to prevent binding to Type II receptors) or [3H]dexamethasone, respectively. Type I receptor binding in brain was found to undergo a dramatic biphasic up-regulation, with levels six times that of intact levels by 24 h post-surgery and a doubling again by 4-8 days post-surgery. By 16 days, however, Type I specific binding had returned to intact levels. Similar, but less dramatic fluctuations were seen in kidney and liver, whereas much smaller fluctuations were seen for Type II receptors in all three tissues. In a follow-up study with Scatchard analyses we observed a similar transient up- and down-regulation in maximal binding for Type I, and to a lesser extent Type II receptors in all three tissues. As expected, the apparent binding affinity for both receptors increased after surgical removal of competing endogenous steroids. Radioimmunoassays revealed that plasma concentrations of corticosterone were reduced to near undetectable levels by 24 h post-surgery. A direct comparison of male and female mice revealed no sex-related differences in Type I receptor binding capacity fluctuations in brain cytosol after adrenalectomy-gonadectomy. Lastly, treatment with exogenous aldosterone or corticosterone was found to prevent adrenalectomy-gonadectomy-induced up-regulation of Type I and, to a lesser extent, Type II receptors in brain. Somewhat surprisingly, the potency of these two adrenocorticosteroids appeared to be very similar for both receptor types.

Adrenalectomy↗
PubMedDate not supplied

Maintenance of sexual behavior in castrate male SW mice using the anti-androgen, cyproterone acetate.

The present study was designed to test the hypothesis that cyproterone acetate (C) might selectively block the actions of dihydrotestosterone (D) and via this action, function as an anti-androgen in male sexual behavior. Sexually experienced male SW mice, a strain previously shown to respond to D following castration, were divided randomly into six groups. Beginning on the day after castration, animals received SC injections for 21 days of either testosterone (T), (D), (C), (T+C), (D+C) or vehicle (V). C was found to significantly reduce seminal vesicle and body weights in all androgen treated groups. There was no evidence to support the contention that C selectively blocks the action of D. To the contrary, in sex tests C maintained palpations, thrust mounts, with intromissions and mounts with ejaculations. Indeed, only animals receiving C alone or in combination with T and D exhibited ejaculations throughout the testing. These results suggest that in the SW mouse, C can work like an androgen in the maintenance of male sexual behavior.

Animals↗
PubMedDate not supplied

Diencephalic sites responsive to prostaglandin E2 facilitation of sexual receptivity in estrogen-primed ovariectomized rats.

Crystalline prostaglandin E2 (PGE2) induced high levels of sexual receptivity when stereotaxically implanted into the antirior-bala hypothalamic and preoptic regions of estrogen-primed, ovariectomized rats. Anterior- as well as medial basal hypothalamic implants of PGE2 induced a significant elevation of rectal body temperature, but had no effect on open-field activity scores. The possibility that PGE2 exerts its facilitatory effects upon sexual receptivity via an LHRH mechanism is discussed.

Animals↗
PubMedDate not supplied

Polyamines in the developing mouse brain.

Polyamine levels were determined during pre- and postnatal development of the male and female mouse brain to assess their possible role during normal brain development. Tissue polyamine levels were increased during periods of neurogenesis and increased cell packing density (assessed by DNA levels) in all brain regions: cerebral cortex, cerebellum, hypothalamus, and rhombencephalon-midbrain. Tissue polyamine levels declined subsequently in a tissue-specific manner toward adult levels. In contrast, the polyamine concentrations per cell were decreased during periods of neurogenesis. A later increase in rhombencephalon-midbrain spermidine levels is consistent with the presumed association of this polyamine with myelin. No sex differences were found in these studies.

Animals↗