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Biomedical subjects

W Harrison

Publications and source records attributed to W Harrison.

125 records · Page 7Linked to original sources
PubMed1981

Keratophakia and keratomileusis: comparison of pathologic features in penetrating keratoplasty specimens.

Two patients, one who had had two keratophakia procedures, and another who had had keratophakia, followed by a keratomileusis procedure both eventually required a penetrating keratoplasty. In the keratoplasty specimen bearing an intrastromal lenticle from a keratophakia procedure performed nine months earlier, no viable keratocytes were found in the in situ lenticle. The lenticle's stroma stained paler with methylene blue and toluidine blue than the host's surrounding stroma, probably due to the absence of proteoglycan synthesis. The interface scar between the lenticle and the host's stroma displayed metabolically active keratocytes, amorphous basement membrane-like material, banded basement membrane material or long-spacing collagen of 1000 A periodicity, microfibrillar collagen of 100 A diameter, and, only in focal areas, more mature-appearing collagen of 200 A diameter. In the keratomileusis-bearing penetrating keratoplasty specimen, complete repopulation of the keratomileusis' stroma by the host's keratocytes had been accomplished after seven months. The absence of any significant tinctorial differences between the keratomileusis' stroma and the host's stroma indicated that these keratocytes were functioning and able to produce proteoglycans. The interface scar between the keratomileusis' stroma and the host's stroma was similar to that in the keratophakia specimen, except for the lesser presence of mature collagen of 2000 A diameter. An explanation is not clearly obvious for the more rapid keratocytic repopulation of the keratomileusis' stroma in comparison with the lenticle's stroma in keratophakia. Both patients had successful penetrating keratoplasties, with postoperative visual acuities of 20/40 and 20/20, owing to the fact that the earlier corneal surgeries had not compromised the integrity of the anterior chamber structures.

Aged↗
PubMed1981

Syringocystadenoma papilliferum of the eyelid.

Two patients presented with slowly developing papillated or hyperkeratotic lesions of their lid margins that began early in the fourth decade. Upon excision, these tumors were discovered to be examples of syringocystadenoma papilliferum, a lesion not previously well documented in the ophthalmic literature. By light microscopy, each tumor displayed surface poral openings where the epidermis underwent a transition into duct-like epithelium, which ramified as luminal channels throughout the tumor. Papillae projected into many of the duct-like spaces and were lined by columnar to multilaminar nonkeratinizing epithelium. A plasma cell-rich infiltrate was present in the connective tissue cores of the papillae. Electron microscopy performed on one of the lesions revealed that the channels were true ducts, with the innermost cells displaying microvilli, small numbers of tonofilaments, and apical junctional complexes composed of a zonula occludens and zonular adherens. These findings, coupled with the location of the tumors at the lid margin and the presence of dilated apocrine glands of Moll deep to one of the tumors, support an apocrine origin. The clinical differential diagnosis of syringocystadenoma papilliferum with respect to other more common lid tumors is discussed.

Adenoma, Sweat Gland↗
PubMed1980

An empirical definition of "primary care".

An operational definition of "primary care", useful to a wide variety of professionals, has eluded researchers since the term first gained popularity. This paper presents an activity-based definition of primary care derived from ratings of 59 representative health care activities by a group of state health administrators, a group of local health department directors, and a random sample of primary care physicians practicing in North Carolina. Thirty-one activities received ratings indicating they were considered core primary care services. Examination of differences in ratings among the three groups surveyed suggested that health department directors differ from the other two groups. Consideration of the variances of activity ratings within the groups emphasizes the unique response of the health department directors and identifies activities characterized by considerable disagreement. The study includes information necessary for researchers and practitioners to form an activity-based definition of varying scope. Definitions constructed from this information should be useful in planning the evaluation efforts that involve different groups of providers, since activities provide an objective basis for agreement. Repeating the approach outlined in the paper with other provider groups in other areas of the country should lead to better understanding of intergroup and regional differences in the concept of "primary care".

Attitude of Health Personnel↗
PubMed1975

Patch testing of coolant fractions.

Dermatitis among machine operators, and others who are consistently exposed to cutting and grinding liquids, has presented the industrial physician with the problems of how to protect the machinist from the cause of his dermatitis and how to detect irritants that may be responsible for the skin problem. In order to examine the various components of machine coolant that might be responsible for causing a dermatitis reaction, 13 suspensions were prepared. They consisted of various combinations of New Codol¿ (coolant base), biocides, masking agent, tramp oil, used coolant and metal fragments. Patch test techniques were used to examine these suspensions for their potential to cause a localized skin irritation on plant employees. Two hundred and six New Process Gear employees were tested over a ten-month period. The participants were management, general salaried employees and hourly labor employees. There was not a single positive reaction in any one of the 206 individuals who completed their skin testing. Of the 206 tested, 29 persons were tested and retested a total of 62 times over a period of one to 25 weeks after the initial testing. In neither the testing nor the retesting was a positive patch test reaction -- irritant or allergic -- obtained.

Adult↗
PubMed1971

Incidence of heat-resistant molds in eastern orchards and vineyards.

Over 70% of the samples of fruit, vegetation, and soil obtained in surveys of New York orchards and vineyards were contaminated with heat-resistant molds. The counts generally were low, under one per gram. Byssochlamys fulva was the most common isolate. Other isolates were identified as B. nivea, Paecilomyces varioti, Aspergillus fischeri, A. fischeri var. spinosus, A. fumigatus, Penicillium vermiculatum, and P. ochro-chloron.

Ascomycota↗
PubMed1970

Enumeration of byssochlamys and other heat-resistant molds.

Methods for the detection of low numbers of heat-resistant molds on fruits were studied by using cultures of Byssochlamys and a number of unidentified mold isolates. Ascospore dormancy had a marked effect on viable recoveries, and the medium in which ascospores were heated influenced activation rates. Best results were obtained when fruit homogenates were heated for 60 min at 70 C in Concord grape juice, followed by culturing on acidified Potato Dextrose Agar.

Journal Article↗
PubMedDate not supplied

Sleep of atypical depressives.

Patients who met provincial criteria for atypical depression were contrasted with a group of patients who met RDC criteria for endogenous depression and a group of normal controls on a standard series of sleep variables. Atypical depressives were differentiated from normal controls by a shortened REMP latency. They did not, however, appear to have the sleep continuity disturbance exhibited by endogenous depressives. This preliminary work suggests that atypical depressives may have a unique pattern of sleep variables consisting of REM abnormalities without continuity disturbance. If this pattern is observed in additional studies, it would add to the validity of considering atypical depression a subtype of unipolar depressive illness.

Adolescent↗
PubMedDate not supplied

Treatment of premenstrual dysphoric symptoms in depressed women.

Although research has established a strong association between premenstrual dysphoric symptoms and depression, there is little data on the effect of antidepressents on premenstrual symptoms. This study compared the efficacy of three treatments--imipramine, phenelzine, and placebo--on the premenstrual symptoms of women with atypical depression who had responded to treatment for their depressive symptoms. The Premenstrual Assessment Form (PAF) was used to rate the type and degree of premenstrual symptomatology. After 12 weeks, at least two-thirds of the women on active medication showed improvement on most measures of premenstrual symptoms to the degree that they had essentially no premenstrual problems after treatment. By comparison, only half of a group of women who had responded to placebo treatment of 6 weeks duration showed such improvement.

Adolescent↗