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Biomedical subjects

W Hohenberger

Publications and source records attributed to W Hohenberger.

At least 19 recordsLinked to original sources
PubMed1995

[Multiple gastric wall abscesses--a rare differential endosonographic diagnosis of submucous stomach tumors].

We report a rare case of a 52 year old patient with multiple gastric wall abscesses. In 1987 a selective proximal vagotomy was performed. Because of non-specific gastric symptoms in 1993 an endoscopy and an endoscopic ultrasound was performed at another hospital which resulted in the likely diagnosis of multiple leiomyomas. Three months later a control endosonography showed three well demarcated submucosal tumors, partly echo-genic, but with an inhomogeneous echo-pattern. A laparotomy and histological examination of the submucosal gastric tumors revealed multiple gastric abscesses with granulomas after selective proximal vagotomy. Difficulties in the differential diagnosis of submucosal gastric tumors arising from this case are demonstrated and discussed.

Abscess↗
PubMed1992

[Regional hyperthermic perfusion--therapeutic concept and long term results].

Isolation perfusion was introduced in 1957 by Creech and Krementz for treatment of malignancies of the limbs. The isolation of the extremity from the body circulation allows a high concentration of cytostatics without systemic side effects. Regionally metastasizing malignant melanomas with satellites, intransit or lymph node metastases are generally accepted indications for isolation perfusion. There is still controversy about elective adjuvant perfusion in stage I melanoma. Prospective randomized studies must clarify this situation. Krementz demonstrated long-term survival rates between 29% and 52%. Our group of patients with satellites and intransit metastases shows a 10-year survival rate of 48%. Considering the historical data of our patients without perfusion and with a 10-year survival of 11%, there is a highly significant statistical difference. In conclusion, isolation perfusion is the therapy of choice in patients with locally metastasized malignant melanoma of the limbs.

Antineoplastic Agents↗
PubMed1992

[Pelvic multivisceral resection from the viewpoint of surgery].

Even rectal carcinomas, carcinomas of the female genital tract, and retroperitoneal sarcomas of the pelvis with invasion of adjacent organs are potentially curable by extending the operation to the relevant structures. In the Surgical Department of the University of Erlangen, 1535 patients with a first diagnosis of rectal carcinoma were treated from 1978 to 1988. Among these patients, 97 multivisceral pelvic resections (patients with distant metastases excluded) were performed. True tumor invasion had occurred in 48%, the others were operated on for inflammatory adhesion. In 54 patients, the anal sphincter was preserved. Postoperative mortality was 7%. The 5-year survival of those patients with tumor invasion of adjacent organs and R0-resection (n = 26) was 32%. Excluding the five patients with a tear or incision of the tumor (n = 5), the 5-year survival of the remaining patients was 44%. One patient who was operated on for a leiomyosarcoma of the rectum with a multivisceral resection of the rectum, prostate, and urine bladder is still alive 9 years after the operation without recurrence. The history of this patient argues for pelvic exenteration also in males, if a R0 resection can be performed.

Female↗
PubMed1991

[Comparison of CT and plain tomography in hilar and lung processes].

A group of 100 patients including 46 patients with suspected bronchogenic carcinoma and 54 patients with suspected lung metastases was evaluated by conventional plain tomography. Patients with preoperatively suspected T4- or N3-categories were excluded. The diagnosis was confirmed in all cases by surgery and histology. In addition, patients with lung metastases were controlled by follow-up chest x-rays (median follow-up time 1.5 years). The diagnosis of plain tomography was true positive in 70% and false in 30%. CT was true positive in 57% and incorrect in 43%. Tumors or metastases were detected with both methods when more than 5 mm in diameter, lesions smaller than 5 mm were overlooked with CT and tomography. Plain tomography an CT did not detect lymph nodes metastases smaller than 1.0 cm.

Carcinoma, Bronchogenic↗
PubMed1990

[Surgical aspects of focal pancreatic lesions].

Focal lesions of the pancreas or its surroundings comprise a variety of morphologic substrates that do not always require treatment. Cysts and neoplasms are the two important groups. Postpancreatic cysts are increasingly and successfully treated by endoscopy and interventions guided by ultrasound. They have to be distinguished from cystic neoplasms or intracavitary hemorrhage which have to be approached by primary surgery. Pancreatic malignancies do not necessarily invite to a fatalistic attitude. Only ductal pancreatic cancer carries a still poor prognosis although we have achieved a 20% 5 year survival rate if resection without residual tumor was possible. If lymph nodes were not involved 43% of patients survived for 5 years. Periampullary carcinoma and the other pancreatic neoplasms carry a much better prognosis. The search for focal pancreatic lesions must be particularly thorough in patients presenting with diabetes of sudden onset, persistent hyperamylasemia and in some cases with an acute, possibly severe pancreatitis without apparent cause and an age of over 40 years.

Humans↗
PubMed1990

[Venous long-term indwelling catheter and port systems in children. Progress in pediatric oncology].

Long-term indwelling catheters of the Broviac, Hickman, Groshong type, and the Port Systems have proved highly suitable as a supportive measure in pediatric oncology. They are indicated for cytostasis, bone marrow transplantation and long-term parenteral nutrition. They provide reliable and safe venous access for therapy and blood sampling. Therapy is thus faciliated, and the quality of the patient's life is significantly improved by reducing the number of venipunctures required.

Blood Specimen Collection↗
PubMed1990

[Discontinuity resection of the colon. Indications and results].

In 83 patients discontinuity resection of the colon was performed. Due to negative selection factors postoperative mortality was 26.5%. In 37 patients continuity of the colon was restored, no patient died postoperatively. The only severe complication was formation of a colovesical fistula requiring a pull-through operation.

Adolescent↗
PubMed1988

Verrucous carcinoma of the esophagus.

The special problems involving the histopathology of verrucous carcinoma of the esophagus are presented on the basis of two patients with this tumor seen at our department. The discussion centers on the question whether a verrucous carcinoma of the esophagus can infiltrate the basal membrane and give rise to metastases.

Aged↗
PubMed1988

[Accomplishments of tumor surgery in tumors of the small intestine].

Between 1. 1. 1970 and 31. 12. 1986/31. 12. 1987, 90 patients with primary malignancies of the small bowel were treated at the Department of Surgery of the University Erlangen-Nürnberg. Only 21% (19 of 90) of the patients had no regional or distant metastases at the time of the operation. The 5-year-survival rate of the 90 patients was 41% +/- 14%. Twenty-one of 34 patients suffering from adeno-carcinoma were treated by curative surgery. The 5-year-survival rate of these 21 patients was 44% +/- 23%. The prognosis of patients with primary malignant tumors of the small bowel depends on early diagnosis and curative surgery.

Adenocarcinoma↗
PubMed1988

[Acute diverticulitis].

A retrospective study of 310 patients from 1978 to 87 showed emergency operations for peritonitis, acute obstruction (5%) and massive hemorrhage (3%) in 22% of the patients and various procedures for abscesses, such as delayed emergency in 14% and elective resections in 41%. Conservative treatment was given to 23% of patients with acute diverticulitis without further symptoms. During followup 68% had no symptoms, while 7% required resection for complications. The death rate for diffuse peritonitis has fallen: from 33 to 16% with Hartmann operation, and for perforations without and with abscesses from 4 to 0% and 12 to 4%, and from 1.2 to 0.6% in elective primary resection.

Acute Disease↗
PubMed1987

[Primary and secondary chest wall tumors--diagnosis, therapy and results].

In a retrospective study 51 patients who underwent chest wall resection for malignant chest wall tumors were reviewed. There were 28 male and 23 female patients with ages ranging from 6 to 76 years (average 50). 34 patients had primary malignant neoplasms (including breast and lung) 17 had metastatic tumors. The tumor was located in the ribs in 45 patients and in the sternum in 6. Reconstruction was with prosthetic material in 16 patients and further plastic reconstruction in 10. Aggressive resection for malignant chest wall tumors and reliable reconstruction can be performed safely, and early wide resection proved to be a potentially curative treatment for primary neoplasms.

Adolescent↗
PubMed1986

[Evaluation of micro- and macrophage function in splenectomized patients--possible dermatologic consequences].

Various micro- and macrophage functions were studied in vitro in 15 patients having previously undergone posttraumatic splenectomy as well as in 100 healthy persons. We found reduced capacity of intracellular inactivation of microorganisms by microphages (7/15) and slight impairment of chemotactic activity in both systems (8/15; 9/13). Possible dermatological consequences are discussed.

Adult↗
PubMed1986

[Functional performance of spleen transplants].

Splenic autotransplants maintain the maturation of erythrocytes. They also sustain the clearance function qualitatively, but from quantitative aspects, they do not work sufficiently. Animal studies concerning the defence of bacterial infections, are divergent. From clinical examinations, a return of various defects by autotransplants is missed, even more, negative results are reported. So, the prevention of OPSI by splenic replantation is questionnable.

Humans↗