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PubMed · 15278236

[Sentinel lymph node in melanoma].

T Meyer·M Möhrle·C Garbe·W Hohenberger
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Abstract

The procedure of sentinel node biopsy (SNB) has emerged as an important advance especially with respect to staging of malignant melanoma. Elective (prophylactic) lymph node dissection that had been practiced in primary melanoma with a suspected increased risk of (clinically occult) lymphatic metastasis has been replaced by SNB. Patients with proven metastatic involvement of the sentinel node (12-25%) can be specifically selected for regional lymph node dissection. Metastatic involvement of the sentinel node (SN) is a significant independent prognostic factor. The value of detecting metastasis by highly sensitive diagnostic tools such as RT-PCR is just as uncertain as is the therapeutic benefit of operative or conservative therapies in sentinel node-positive patients with respect to improving prognosis and is currently under study.

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Clinical Trials as TopicColoring AgentsHead and Neck NeoplasmsHumansLymph Node ExcisionLymph NodesLymphatic MetastasisMelanomaMulticenter Studies as TopicNeoplasm StagingPractice Guidelines as TopicPrognosisRandomized Controlled Trials as TopicRisk FactorsSentinel Lymph Node BiopsyComparative StudyEnglish AbstractJournal Article

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T Meyer, M Möhrle, C Garbe, W Hohenberger. 2004. [Sentinel lymph node in melanoma].. https://doi.org/10.1007/s00104-004-0934-5

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