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Biomedical subjects

W Künzel

Publications and source records attributed to W Künzel.

At least 217 records · Page 12Linked to original sources
PubMed1983

Heart rate and blood pressure response and metabolic changes in the sheep fetus following reduction of uterine blood flow.

The cardiovascular and metabolic responses during acute fetal hypoxia were studied in 7 pregnant sheep near term. Complete reduction of uterine flow (UBF) for 180 s was performed in 13 experiments by inflating a balloon positioned in the maternal aorta. Fetal heart rate (FHR), systolic and diastolic blood pressure (BP) and fetal arterial oxygen saturation (SO2) were measured continuously. Blood samples were taken at short intervals and analyzed for pH, PCO2, PO2, SO2, base excess and lactate. Following the reduction of UBF, FHR began to rise after 4.7 +/- 14.4 (SD)s and fell after 31.3 s paralleled by the rise of the BP after 23.2 +/- 8.2 (SD)s. The fall of FHR was not related to the SO2 at control, but to the decline of the SO2 by 10-15%. There was no critical limit of SO2 at which the FHR started to fall and the BP began to rise. The rise of the FHR after UBF had been released was significantly correlated to the rise of SO2. Lactate production during hypoxia was related to the slope of the SO2 decline, i.e., to the fetal O2 consumption. The total metabolic response during hypoxia and recovery given by the pH area was correlated to the SO2 at control. No correlation between dip area of FHR and PH area could be established.

Animals↗
PubMed1982

[Not Available].

Explore the source record for details and available documents.

Dentistry↗
PubMed1982

[Type III shortrib-polydactyly syndrome (Verma-Naumoff) in concomitance with ectodermal dysplasia (author's transl)].

Reported in this paper is a case of shortrib-polydactyly syndrome in a stillborn male infant. The case was identified as Type III (Verma-Naumoff) on account of typical skeletal findings, such as very short ribs, micromelia, postaxial hexadactyly of all extremities, and shortened cranial base, with due consideration being also given, in that context, to characteristic radiographic and histological changes, including metaphysial spurs of long cylindrical bones. Malformations were recorded also from kidneys, ureters, small intestine, and pancreas.--Thin downy head-hair, missing eyebrows, precocious dentition, as well as partial hypoplasia and aplasia of nails were interpreted as signs of ectodermal dysplasia.--Shortrib-polydactyly syndrome is based on autosomal recessive inheritance. Early genetic advice should be offered to parents. Systematic prenatal diagnosis is necessary in case of another pregnancy.

Abnormalities, Multiple↗
PubMed1981

Umbilical circulation--physiology and pathology.

1. The umbilical circulation under physiological conditions is protected by the amniotic fluid. This protective mechanism of the amniotic fluid may be disturbed artificially or spontaneously by the rupture of the membranes. 2. Umbilical cord compression is of no harm to the fetus when it is mild, since the fetus possesses a circulatory buffer system when umbilical blood flow is in a physiological range. However, severe reduction of umbilical blood flow may lead to fetal hypoxia. 3. Chronic or repetitive acute fetal hypoxia leads to deterioration of fetal circulation and umbilical blood flow. This can be recognized by the obstetrician during labor based on fetal heart rate patterns.

Animals↗
PubMed1981

[Hypotensive disorders during pregnancy as a cause of fetal hazard (author's transl)].

Hypotension during pregnancy is correlated with a perinatal mortality of 5.08%. Premature birth and growth retardation of the fetus in patients with hypotension are also often seen. The cause of hypotension is most likely a redistribution of the maternal blood volume in distended areas of the venous system and a low blood volume per se. The approach for the treatment of hypotension and the improvement of fetal well being may be the application of compounds which prevent the dilation of the venous vessels. A second approach could be the application of Desoxy-corticosteron-trimethyl-acetat (DCTA) to improve the maternal blood volume by retention of potassium. Both has to be examined in well defined investigations.

Desoxycorticosterone↗
PubMed1981

[The variability of fetal heart rate response to the reduction of uterine blood flow in anaesthetized and unanaesthetized pregnant sheep].

The variation of the fetal heart rate (FHR) and blood pressure (BP) response to a definite hypoxic stress has been investigated in 3 unanaesthetized and 8 anaesthetized near term pregnant sheep. Uterine blood flow (UBF) was reduced by inserting an inflatable balloon into the maternal aorta in 33 experiments. By inflation of the balloon blood flow was reduced to zero for 5-60 sec. The response on fetal heart rate an systolic and diastolic blood pressure has been measured. The lag time of the response was estimated. Following the reduction of uterine blood flow fetal heart rate fell and the blood pressure rose. The fall of FHR and the rise of fetal systolic and diastolic BP was correlated to the duration of flow reduction. There was however a wide variation of the FHR and BP response to a definite duration of flow reduction which was also dependent on the application of anaesthesia. A relationship between the oxygen saturation at control and the FHR and BP response could not be established. From this experiment it may concluded that the application of anaesthetics reduce the FHR and BP response. In addition the duration and the fall of the FHR is not good measure for estimating the severity of fetal hypoxia.

Anesthesia↗