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Biomedical subjects

W Konen

Publications and source records attributed to W Konen.

66 records · Page 4Linked to original sources
PubMed1984

[Torsten-Sjögren syndrome].

The Torsten -Sjögren-syndrome is the combination of hereditary cataract associated with impaired central nervous coordination, mental retardation and hyperaminoacidurea . This recessive inheritable disease is due to an alteration of the aminoacidmetabolism also present in the not manifestly affected parents. In addition, the presented case exhibited an anal atresia with perinatal fistula. The pediatric and ophthalmologic aids have been started early. According to the etiology a genetic counceling is necessary.

Amino Acid Metabolism, Inborn Errors↗
PubMed1983

[Therapeutic soft lenses following keratoplasty, indications and complications].

A reported on 27 eyes (25 patients) which were fitted with soft permanent lenses following penetrating keratoplasty. The eyes were divided into three groups, according to the nature of the epithelial damage caused by the lens: 1) mechanical damage; 2) primary damage to the endothelium with secondary epithelial resistance. In 52% of the cases superficial neovascularization occurred, but this did not lead to serious complications. In the first and second groups, infiltrates were only seen after longterm use. The highest rate of complications, with infiltrates occurring relatively early and with liquefaction, was observed in the third group. In the first group the permanent lens led to lasting stabilization of the condition with a relatively low risk. In the second group the lens brought freedom from complaints with complications occurring only after 1-2 years. In the third group it was found that complications with negative courses may arise after only a short time.

Contact Lenses, Hydrophilic↗
PubMed1977

[Immunosuppressive treatment of Behçet's disease (author's transl)].

Report on the results of immunsuppressive therapy in 6 patients with Behçet's disease. A combined regimen of azathioprine and cortisone improved the course of the disease and diminished the number of recidives. In order to prevent irreversible damage to the eye early immunosuppressive therapy is advocated. Because of possible side-effects of azathioprine the necessity of further treatment should be reevaluated after several months without symptoms and then gradually terminated.

Azathioprine↗
PubMed1975

Bioavailability of m-octopamine in man related to its metabolism.

The diminished sympathomimetic pressor activity of monohydroxylated phenylalkylamines after oral administration has been attributed to incomplete enteric absorption. Therefore, urinary excretion of the unchanged drug and its metabolites has been compared after intravenous and oral administration of 3H-m-octopamine to eight patients. Identical amounts of 3H-activity (80% of the dose) were excreted after the two routes of dosing, so enteric absorption has been assumed to be complete. Significant differences were found in the fraction of free urinary m-octopamine, which amounted to 10.5% of the dose after infusion and 0.58% after oral administration. The only metabolic pathways for m-octopamine are deamination and conjugation. Following oral administration the percentage of conjugates was considerably higher than after intravenous infusion. This metabolic pattern appears typical of all phenylalkylamines with a hydroxyl group in the meta position. Ring hydroxylation to catecholamines was not observed. The enzymes mainly responsible for conjugation after oral administration are located in the gut wall. The resulting ""first pass effect'', i.e. metabolism prior to the access to the central compartment, can account for the diminished pharmacodynamic effect after dosing by this route.

Administration, Oral↗
PubMedDate not supplied

Fibrosis adjacent to the anterior lens capsule after extracapsular cataract extraction.

Fibrosis, contraction and opacification of the posterior lens capsule after extracapsular cataract extraction, is a frequent complication following cataract surgery. In these cases, cellular proliferation occurs along an intact posterior capsule. We report a case of fibrosis adjacent to the anterior lens capsule, where cellular proliferations and collagen production completely sealed the anterior capsulotomy three months after a routine extracapsular cataract extraction with implantation of a posterior chamber lens. The fibrosis led to contraction of the remainder of the anterior capsule, significantly reducing vision. Examination of the excised material by light and electron microscopy, and immunohistochemistry, revealed cells with features compatible with fibrocytes that did not stain positive for cytokeratin. The cells were situated in a dense collagen matrix. An anterior capsulotomy that is too small prevents sufficient removal of lens epithelium, and may be a risk factor for this complication.

Aged↗