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Biomedical subjects

W Müller

Publications and source records attributed to W Müller.

At least 649 records · Page 36Linked to original sources
PubMed1986

[Tumor removal using performance ultrasound. Report of 50 brain tumor operations].

A report is given on the method of the tumour aspiration of cerebral tumours by means of power ultrasound. After classical exposure of the tumour--obligatory performance with physical-pharmacological reduction of the metabolism and in most cases under hypotension--the tumour is destroyed by ultrasonic power and simultaneously aspirated. A report is given on 50 cerebral tumour operations, which were carried out in Karl-Marx-Stadt within two years, using the tumour aspiration system "Aspirus 120". Finally the advantages of the method are summarised and dangers interpreted. At the end a valuation of the method is attempted and an outlook is given.

Brain↗
PubMed1986

[Tumors of the facial nerve canal].

The X-ray tomograms of 13 patients with tumors in the facial nerve canal are discussed. The leading clinical symptom is the peripheral facial nerve palsy without recovery, often combined with deafness and dizziness. The X-ray film shows opacity, widening of the internal auditory canal and/or of the third part of the facial nerve canal, further erosion of the bony structures and destruction of the pyramid.

Cranial Nerve Neoplasms↗
PubMed1985

Interference of IgM rheumatoid factor with nephelometric C-reactive protein determinations.

Different nephelometric assay systems for quantitation of C-reactive protein (CRP) were compared with radial immunodiffusion (RID) and tested for their susceptibility to interference by serum IgM rheumatoid factor (RF). In 3 nephelometric assays, RF was found to elevate CRP values. Sera with high RF content from patients with rheumatoid arthritis gave significantly higher CRP values by nephelometric assay than by RID; the addition of purified RF to RF-negative sera increased CRP values markedly; and removal of RF from sera corrected falsely elevated CRP values. This interference by RF is explained by the action of human RF as a (secondary) antibody reacting with complexed mammalian IgG anti-human CRP in the assay. In this way the nephelometric signal is enhanced to give falsely elevated CRP values. In contrast, the gel diffusion RID method does not suffer from this non-specific interference.

Arthritis, Rheumatoid↗
PubMed1985

Fluorescence monitoring of rapid changes in membrane potential in heart muscle.

The rising phase of rat cardiac action potentials was measured in physiological solutions using the voltage-sensitive dye RH 237. A newly designed optical system and an argon ion laser for excitation allowed measurements without averaging over small areas (20-90 microns diameter) with high time resolution (response time 10-90%, 0.12 ms). The mean value of the fractional change in the fluorescence signal was approximately 3%/100 mV. The signal-to-noise ratio was approximately 60 rms (spot diameter 70 microns) allowing signal differentiation after digital filtering. Multiple measurements within the same spot showed a decrease in the fractional fluorescence change of 20 to 25% after 45 min without changes in the shape of the rising phase and with no measureable phototoxic effects. The optically measured rising phases showed rise times significantly (P less than 0.01) shorter and maximum upstroke velocities equal to or most often greater than those obtained with microelectrode techniques. Comparing simultaneous optical and electrical measurements within the same spot the microelectrode signal was often slightly delayed. This refined system seems well suited to detect fast cellular electrical activities with time and space resolutions comparable or even superior to those obtained using microelectrode techniques.

Action Potentials↗
PubMed1985

Immunopathology of AIDS (acquired immune deficiency syndrome) observations in 75 patients with pre-AIDS and AIDS.

Sequential changes in the morphology of immunocompetent and other organs, in the accompanying immunocytological and immunovirological measurements are described in 75 patients with lymphadenopathy syndrome and with AIDS. The data presented demonstrate a stepwise development of the disease from a hyperimmunization syndrome to T-cell immune deficiency. Excessive antigenic stimulation by a large number of infectious organisms or by transfusion of blood and blood products account for antigenic overloading and hyperimmunization. Among such infectious organisms are certain viruses which per se interfere with cells of the immune system as for instance Epstein-Barr virus, cytomegalovirus, and HTLV3. Developing immunological incompetence will favor the persistence of these and other infectious organisms enhancing the damage of the immune reactivity and finally allow lethal infections or malignant tumors to occur.

Acquired Immunodeficiency Syndrome↗
PubMed1985

[Interpretation of electroretinographic findings in posterior uveitis].

The present paper deals with the electroretinographic findings in 30 patients with inflammatory or postinflammatory disturbances of the fundus. The alterations of the scotopic ERG depend on the localization and extent of the disease. The individual components of the ERG are affected differently. It is evident that in a high percentage of patients with unilateral disease the ERG of the fellow eye was affected as well. This might be due to an immunologic reaction. It is pointed out that further investigations are required in order to resolve the problems involved.

Chorioretinitis↗
PubMed1985

Increased concentrations of milk antibodies in recurrent pulmonary aspiration in infants and young children.

Concentrations of circulating antibodies against bovine serum albumin were significantly increased in six children with recurrent pulmonary aspiration (mean: 5.54 micrograms BSA-N/ml, range: 2.05-12.87 micrograms BSA-N/ml; mean value of 76 control infants: 0.38 microgram BSA-N/ml, 95% confidence interval: 0-0.98 microgram BSA-N/ml, p less than 0.001) as determined by radioimmuno-assay. IgG- and IgA-isotypes against bovine serum albumin, lactalbumin, lactoglobulin, casein and gammaglobulin were determined in four patients by enzyme-linked-immuno-sorbent-assay. Significant differences between patients and controls were found for IgG-antibodies against casein and bovine serum albumin and IgA-antibodies against alpha-lactalbumin and bovine serum albumin. Under certain conditions, stimulation of bronchus-associated lymphoid tissue may lead to a higher immune response than oral immunization. Determination of milk antibodies may be helpful in the diagnosis of recurrent pulmonary aspiration.

Antibodies↗
PubMed1985

Signal requirements for growth and differentiation of activated murine B lymphocytes.

Mouse B lymphocytes were stimulated at high cell concentrations with goat anti-IgM antibodies, which leads to the induction of B cell proliferation without the addition of any growth factors. After 48 hr, blast cells were purified and cultured at low cell concentrations. Proliferation and differentiation of purified B lymphocyte blasts is then dependent on the addition of either mitogens (e.g., LPS) or certain lymphokines derived from activated T cells or macrophages. One such lymphokine was isolated from supernatants of various activated T cells and characterized by gel filtration as a material with an apparent m.w. of 40,000 to 50,000, similar to BCGF II. It supports the proliferation of the B cell blasts and induces their differentiation into plaque-forming cells. Lymphokines such as BCGF I, interleukin 2, and BCDF gamma could neither maintain growth nor induce differentiation of B lymphocytes preactivated by goat anti-IgM.

Animals↗