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Biomedical subjects

W Müller

Publications and source records attributed to W Müller.

At least 757 records · Page 42Linked to original sources
PubMed1981

[Aarskog syndrome (author's transl)].

Report of radiologic and hormonal results of a patient with typical stigmata of the Aarskog-syndrome. X-Ray findings are not been found to give diagnostic clues, whereas the hormonal findings are considered specific-typical: FSH and LH levels prior to orchidopexy are in a range are as seen with hypergonadotropic hypogonadism. One year after the orchidopexy LH values were found to be normal, the FSH again showed increased titer. The growth hormones concentrations are normal but Somatomedin-activity is decreased.

Abnormalities, Multiple↗
PubMed1981

[Basic studies on ultrasonic surgery. I. Principles, status and perspectives of ultrasonic surgery].

The ultrasonic power with regard to its medical use for resection, treatment, and joining of soft and hard biologic tissues is investigated after the formation of the ultrasonic diagnostics and therapy. The situation of the ultrasonic surgery as an unconventional method for the ingenious complementation of tested operative techniques is valued after the representation of the mode of operation and the present equipment. The trend of development and prospective problems of the research are deduced from them.

Amputation Stumps↗
PubMed1981

Influence of a portacaval shunt on the distribution of 14C-chol-PC-DCP-liposomes and liposome entrapped 3H-methotrexate in the organs of rats.

The individual roles of hepatic parenchymal cells and non-parenchymal cells in the uptake of intravenously injected liposomes by the liver have not yet been clearly determined. Experimentally, it is suggested that a portacaval shunt reduces the phagocytic capacity of the liver RES. In our experiments a portacaval shunt does not influence the hepatic uptake of 14C-Chol-PC-DCP-liposomes and the liposome entrapped 3H-Methotrexate in rats. In normal rats and in rats with a portacaval shunt, most of the 14C- and 3H-radioactivity is found in the liver and the ratio between the amounts of free and liposome entrapped radioactivity 3 to 15 hours after i.v. injection is approximately 1:10. Therefore, it is concluded that the liver RES does not play an integral role in the enrichment of liposomes in the liver.

Animals↗
PubMed1981

[Cyclosporin A--effects and side effects in the treatment of rheumatoid and psoriatic arthritis (author's transl)].

The treatment of rheumatoid arthritis and psoriatic arthritis with cyclosporin A is described. Cyslosporin A is a new selective immunosuppressant which acts primarily on the T lymphocytes. It has already been shown to be effective in preventing rejection following kidney transplantation as well as in preventing graft-versus-host disease. In rheumatoid and psoriatic arthritis, however, its effect was not satisfactory, although rather different in the two conditions; overall only about one third of the patients showed any marked improvement. By contrast, and for reasons which are as yet unexplained, it had a beneficial effect on the cutaneous symptoms of psoriasis. Cyclosporin A had little effect on immune parameters. Side effects--mainly kidney toxicity, gastro-intestinal reactions and hirsutism--were common but reversible. On present evidence its principal indication among rheumatological diseases would seem to be as a treatment for severe, intractable psoriatic arthritis.

Aged↗
PubMed1981

[Surgery in craniofacial syndromes (author's transl)].

Craniofacial surgery deals with the correction of congenital acquired deformities of the skull and face. This kind of surgery together with microsurgery can be regarded as the most outstanding development within the past decade. Plastic surgery, as the center of organisation is responsible for coordination with many other medical disciplines. Since 1978 an interdisciplinary group for craniofacial surgery started with operations at the University Hospital for Plastic Surgery in Innsbruck and the Department for Plastic Surgery at the Klinikum rechts der Isar in Munich. In this article first experiences are reported and three cases, a Morbus Apert, a Morbus Crouzon and a Hypertelorismus presented. The indication for such treatment is directed for functional disturbance but also for aesthetical reasons to improve the psycho-social structure of the patient. An early operation is indicated in stenosis of cranium and face to avoid damage of the brain and eyes. If not urgent, these interventions should be started beyond the age of about 8, after dentition.

Child↗
PubMed1981

[Asymmetric mixed gonadal dysgenesis (author's transl)].

We would like to report a girl, 11 7/12 years old, with the typical signs of an asymmetric mixed gonadal dysgenesis (amgd). The external genitalia were ambiguous, the inner genital organs contained a dysgenetic testis on the right side an ovarian "streak" on the left. At laparatomy follopian tubes were found bilaterally. On the right side the microscopic specimen showed an epididymis. There was an unicornuate malformation of the uterus. The karyotype, first examined 1969 in the age of a few month, showed chromosomal mosaicism, 45 XO/46 XX. In 1980 this problem was reevaluated, because now the HY-antigen-determination was available, this was uniformally found to be positive in our patient. Now the new karyotype with special methods was 45 XO, 46 X dic (y)/47 XY + dic (y). This karyotype was, to ower knowledge, never seen before in amgd. Particular emphasis was payed to the discussion of the pathogenesis of this karyotype and the amgd in general. We would like to consider this intersexual malformation as a prototype of a chromosomal induced disturbance of somatic sexual differentiation.

Child↗
PubMed1981

[The tenacity of air-borne bacteria. II. Communication: Experimental investigations carried out for determining the kill constant beta biol for cocci (author's transl)].

The kill constants beta biol. for cocci are determined in a static aerosol chamber. To do this, the particle diminution (living and dead colony-forming units, KE) is determined with a scattered light photometer and the decrease in reseedability of the colony-forming units is measured by a six-stage Andersen collector. The difference is the kill constant beta biol. which is independent of the physical diminution. For use with model calculations it is recommended that limit values should be assumed which realistically express the wide scatter range of the values.

Aerosols↗