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Biomedical subjects

W Niedner

Publications and source records attributed to W Niedner.

At least 37 records · Page 2Linked to original sources
PubMed1981

[Dexamethasone for prophylaxis against respiratory distress syndrome - progress report (author's transl)].

Reported in this paper is experience obtained from antenatal RDS prophylaxis, using 4 mg of dexamethasone, on three consecutive days. Treatment was applied to 202 premature newborns, and these were compared with 252 untreated controls born on same term. Good success with statistical significance was recordable only from comparison between the two complete groups. - The mother's situations quite often were complicated by outbreak of infections in the wake of obstetric intervention for premature rupture of the amniotic sac. In view of the partial success of dexamethasone prophylaxis and with no alternative to glucocorticoid treatment so far available, continuation of RDS prophylaxis, using dexamethasone, is recommended, however, with strictest observance of contraindications and with higher doses.

Anti-Bacterial Agents↗
PubMed1981

[Correlation between acidosis and consumptional coagulopathy in foetal blood (author's transl)].

Comparative chemical tests, under laboratory conditions, of 20 newborns with normal pH and 20 children with acidotic pH values in blood obtained from the umbilical artery have shown that in newborns medium acidosis resulted frequently is disseminated intravascular coagulation, whereas advanced acidosis led to the same situation with regularity. The thrombocytes, coagulation factors II and V, of the authors' acidotic newborns were clearly exposed to consumption. Thrombin time, partial thromboplastin time, and reptilase coagulation time were prolonged with significance. All coagulation parameters were found to correlate linearly with the postnatal pH values. Systematic efforts to detect disseminated intravascular coagulation should be made in all cases in which the postnatal umbilical artery pH of newborns in 7.09 and below. Determination of haematocrit, thrombocyte count, and fibrinogen degradation products may be sufficient as an immediate-action minimum programme in such cases.

Acidosis↗
PubMed1981

[Results of eclampsia treatment--analysis of 44 cases over 20 years (author's transl)].

Reported in this paper are 44 cases of eclampsia recorded from among 61,809 deliveries at the Gynaecological and Obstetric Hospital of the Medical Academy of Erfurt, between 1960 and 1979. Five mothers died and two more suffered permanent damage. Two infants died perinatally. However, an estimate of eclampsia risk to patients with gestosis cannot be derived from the intensity of the gestosis symptoms and thus from the gestosis index (Goecke).

Adult↗
PubMed1981

[Deliveries by caesarean section--variation of indications (author's transl)].

Reported are 657 cases of caesarean section performed in selected periods over the past two decades. An account is given of change in indications and the results accordingly achieved. Particular reference is made to higher risk of infection due to antepartum and intrapartum intensive care. Indications should continue to be based on most stringent criteria.

Cesarean Section↗
PubMed1981

[Effectiveness of clinical action in treatment of premature birth problems (author's transl)].

The effectiveness of clinical action on a general premature birth situation was studied against the background of 21, 244 childbirths (twins and stillbirths included), in the District of Erfurt, between 1974 and 1979. Clinical attention was considerably stepped up in all cases of imminent premature birth. Steps taken included hospitalisation, sedation, medicamentous tocolysis, cerclage, maturity induction, and organisational measures. Many more people than ever before were called in for action. Yet, no significant change was achieved, neither in terms of the absolute premature birth rate nor in restricting such problems to higher age or weight groups. -- Sizable reduction of perinatal mortality in the period under review was in no way related to measures to reduce the premature birth rate, but it was rather attributable to improvement in prenatal and intranatal diagnosis and in postnatal care. -- The conclusion is that action outside hospital should be intensified.

Female↗
PubMed1980

[Asphyxial shock and disseminated intravascular coagulation (DIC) in animal experiments. 3. Secondary fibrinolysis (author's transl)].

In artificially hypoxic rabbit foetuses, rising hydrogen ion concentration with excessive precipitation of fibrin in the microcirculation, with pH values between 7.0 and 6.9, was followed by discontinuation of DIC on account of predominant regular occurrence of secondary fibrinolysis. Such processes of secondary fibrinolysis, which could be inhibited by para-amino methylbenzoic acid (PAMBA), were found to be capable of re-opening completely the circulatory tracks in surviving foetuses. In other cases, they might persist beyond death and cover up pathologico-anatomic findings, if neglected.

4-Aminobenzoic Acid↗
PubMed1980

[Pregnancy, delivery, and puerperium of patients with constitutional thrombopathy (author's transl)].

Von Willebrand's disease was found to play a particular role in obstetrics for its physiological peculiarities of coagulation which cause haemorrhage disorders after childbirth and during the puerperal period rather than during pregnancy and in concomitance with labour. A comprehensive account of the problem is given, with reference being made to the author's cases.

Blood Coagulation Tests↗
PubMed1980

[Pathophysiology of asphyxiae shock (author's transl)].

An account is given of the asphyxiae shock to introduce more publications on animal experiments, in the context. The asphyxiae shock is a problem of wide ramifications on perinatal morbidity and mortality. Discussed and graphically described are the pathophysiological processes in macrocirculation and microcirculation along with foetal hypoxia together with the effects of those processes upon the coagulative system of the foetus. The author's own studies had been prompted by unelucidated problems, in that context.

Animals↗
PubMed1980

[Acquired disorders of coagulation among patients at a centralised obstetric unit (author's transl)].

Treatment was given for 34 757 childbirths and 5,317 abortions at the Gynaecological Hospital of Medizinische Akademie Erfurt, GDR, between 1967 and 1977. Disorders of coagulation were recorded from 0.207 per cent of all cases. These had been caused by premature placental detachment, amnion infection, dead foetus syndrome, amniotic fluid embolism, septic abortion, and missed abortion. Incidence, mortality, and therapeutic policies are discussed.

Abortion, Missed↗
PubMed1980

[Asphyxial shock and disseminated intravascular coagulation (DIC) in animal experiments. 1. Histological picture (author's transl)].

The effects of subacute intra-uterine hypoxia on the haemostatic system of 205 foetuses from 49 pregnant rabbits were studied by a standardised experimental arrangement, with particular reference being made to intravascular precipitation of fibrin. The asphyxial shock thus induced was accompanied by almost all the rabbit foetuses by disseminated intravascular coagulation by which the central organs were more strongly affected, as compared to peripheral organs also restricted by the shock. The pathophysiological processes which were found to take place in the lungs and placentas of the experimental animals proved different from those in man, which was attributable to species-related differences.

Animals↗