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Biomedical subjects

W Niedner

Publications and source records attributed to W Niedner.

At least 55 records · Page 3Linked to original sources
PubMed1980

[Asphyxial shock and disseminated intravascular coagulation (DIC) in animal experiments. 2. Morphometric tests and blood coagulation studies (author's transl)].

First intravascular coagula were detected as early as in the pre-acidotic phase of artificially hypoxic rabbit foetuses used by the authors in experimental studies. Growing acidosis in circulating blood has been accompanied by excessive increase of fibrin precipitation in the terminal blood track. Further increase of intravascular coagulation was found to be discontinued by predominance of secondary fibrinolysis at blood pH around 6.9. Rising hydrogen ion concentration, as a reflection of a consumptional reaction, was found to be accompanied by decline in both the fibrinogen level and thrombocyte count in the foetal blood, fully in parallel with the above DIC.

Animals↗
PubMed1980

[Diaplacental inhibition of fetal blood coagulation in pregnant sheep (author's transl)].

We investigated the effect of the synthetic low-molecular thrombin inhibitor 4-amidinophenyl-pyruvic acid (APPA) on the maternal and fetal coagulation at 10 far advanced in pregnancy sheep. APPA inhibits as well the maternal as by diaplacental passage the fetal hemostasis in dependence on the dosage till the incoagulability. The effect in the fetal organism occurs after a delay of some minutes and wars of a bit earlier.

Animals↗
PubMed1979

[Animal experiments to study placental passage of Sombrevin and Hexobarbital and their concentrations in various foetal organ systems (author's transl)].

Studies were conducted into 55 rabbits and their 327 foetuses to measure the two intravenously applied anaesthetics, Sombrevin and Hexobarbital, for their passage through the placenta and for the concentrations which eventually settle in various organ systems of the foetuses. Fast placental passage, but in different concentrations, was established for either anaesthetic. Sombrevin was found to reach the foetal organism only in low quantity and for short-time retention, whereas Hexobarbital passed the placental barrier in much higher concentration to stay detectably for a longer period of time in the foetal blood. While Sombrevin was not recordable from foetal organs, its intraplacental buildup reached higher concentrations. Relatively high concentrations of Hexobarbital were recordable from both the placenta and vital foetal organs. The conclusions so far derived from those animal experiments seem to suggest a superiority of Sombrevin over Hexobarbital and regard to applicability to obstetric anaesthesia.

Animals↗
PubMed1979

[Indications for induction of labour beyond full term (author's transl)].

Reported in this paper are diagnosis, therapy, and results in the context of suspicion of overdue pregnancy of cases recorded between 1974 and 1977. The presumed data of delivery rather than the calculated date is taken for reference. That approach has been taken against the background of a high-accuracy determination scale which, in turn, is based on complete case history data and current findings. The intention has been widest possible limitation of the probability of having deliveries overdue by 14 days. Such overdue deliveries were reduced to 240 in 13,172 pregnancies (1.82 per cent) by using this approach. In that context, an unambiguous differentiation was made between testing for possible labour onset and induction of labour, the latter being defined as strictly indicated obstetric action for the unlimited purpose of complete childbirth. Absence of possible labour onset, 14 days beyond term, was an indication for induction of labour in 188 women. Peripartal and real perinatal mortality (one malformation) was zero in 240 cases. Acidosis, but not in advanced stage, was recorded from five per cent of the newborns. The risk now can be more conveniently calculated. In other words, it is more systematically taken in unavoidable cases, an aspect meeting not only the demand on efficient obstetric action but legal requirements, as well.

Female↗
PubMed1979

[Blood pressures in gestosis patients under general anaesthesia following hypotensive treatment (author's transl)].

A retrospective evaluation was made of the blood pressures of 131 patients with hypertensive late gestosis who had undergone caesarean section for maternal or foetal indications, between 1971 and 1977. Rauwolfia preparations should be avoided in both long-term and acute hypotensive treatment of late gestosis patients not only for their unfavourable impact upon circulation at large, but also for their cumulative effects in terms of drastic depression of blood pressure in case of anaesthesia necessary for whatever reason. Acute hypotensive-sedative treatment should be discontinued and resumed, only if necessary, not until anaesthesia is over following surgical termination of pregnancy. Imminent eclamptic fit would be the only exception acceptable. Anaesthesia should be induced, using the base anesthetic propanidid which worked extremely well in terms of circulatory stabilisation. It is obviously superior to barbiturates in that particular respect.

Anesthesia, General↗
PubMed1977

[Hemoperitoneum in the newborn infant].

Among 46272 term and preterm newborns 6 cases (0,13%) of massive intraabdominal hemorrhages could be found. The origin of hemorrhage was in 5 cases the liver. Premature newborns with severe respiratory distress had the main incidence (4 cases). Organic lesions were seen in 2 cases only and other traumatic causes could not be detected. Therefore, the term "abdominal birth injury" should in such cases be replaced by "Neonatal hemoperitoneum".

Adult↗
PubMed1977

[Beta-glucuronidase activity in human ovarian tissue during the life- and cycle-phases of the woman].

The behaviour of the beta-glucuronidase activity during the life phases and the phase of the cycle of a woman has been studied in 51 human ovaries after the Dohrmann method. The study clearly indicates a dependency on age, that is demonstrated by a rise in beta-glucuronidase activity from 536 microgram Ph/h/g ovarial tissue during full functioning to 705 microgram Ph/h/g ovarial tissue in the premenopause and by dropping to 529 microgram Ph/h/g ovarial tissue in the menopause and the senium. The premenopause values are significantly higher compared to that of the other two functional phases. The activity of the beta-glucuronidase is significantly higher in the secretory phase than in the proliferation phase. Existing relations between the beta-glucuronidase of the ovary and the gonadotropic hormones of the hypophysis and the oestrogen metabolism are discussed.

Adult↗
PubMed1976

[Modification of glycylglycine dipeptidase activity in the human ovary using follicle stimulating hormone. I].

The glycyl glycine dipeptidase activity under the in vitro influence of two follicle-stimulating hormone preparations of different concentration was investigated in 36 ovaries. A significant impediment was observed under Folistiman, whereas under Anthrogon the impediment could only be detected with higher concentrations. The FSH/ICSH relation evidently plays an important role in this respect. The results are in support of the statement that the glycyl glycine activity in vivo also depends on the gonadotrophin production. At the same time they affirm the fact that not only endopeptidases play a role in the hormone metabolism of the ovary.

Adnexa Uteri↗