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Biomedical subjects

W Raab

Publications and source records attributed to W Raab.

At least 55 records · Page 3Linked to original sources
PubMed1981

Glucose-6-phosphatase dehydrogenase activity in rat urine. Changes following kidney damage (short report).

In rat urine, G-6-PDH activity is regularly present. Following the administration of nephrotoxic substances (D-serine, tetrathionate), or after elicitation of vascular shock (hypoxic kidney damage), a statistically significant increase in urinary G-6-PDH activity occurs. The alterations in urinary G-6-PDH activity largely correspond to the changes in urinary AP activity which, in this study, was determined in all of the experiments.

Alkaline Phosphatase↗
PubMed1980

[Effect of imidazole derivatives on various numbers of microbes to determine microbial sensitivity].

Imidazole derivatives with antifungal activity were investigated in their effects on concentrated and diluted suspensions of Saccharomyces cerevisiae, Candida albicans, and Staphylococcus aureus haemolyticus. Against Candida albicans, activity of the imidazol derivatives was higher in diluted suspensions than in concentrated suspensions: this fact proves the presence of a microbe-count sensitivity. Against Saccharomyces cerevisiae and Staphylococcus aureus haemolyticus, no microbe-count sensitivity of clotrimazole, econazole nitrate, ketoconazole, or N-148/76 could be detected by Warburg assay on resting microbes.

Candida albicans↗
PubMed1980

[Interactions between amphotericin B and hydroxytetracycline].

By means of the Warburg assay (manometric technique), investigations were performed to elucidate interactions between amphotericin B, a polyene antifungal antibiotic, and hydroxytetracycline. Those two compounds were combined in clinical therapy. On resting yeasts and bacteria, interactions could be ruled out. On the contrary, on both types of microbes a significant increase in antimicrobial actions could be seen in the presence of the second substance. The antimycetic activity of amphotericin B was significantly increased in the presence of hydroxytetracycline (in five-fold concentrations). The antibacterial activity of hydroxytetracycline was significantly higher in the presence of amphotericin B (same concentrations). The clinical implication of these results is briefly discussed.

Amphotericin B↗
PubMed1980

[Effect of long-wave ultraviolet light (UV-A) and medium-wave ultraviolet rays (UV-B) on human skin. Critical comparison].

When discussing the effects of ultraviolet radiation on human skin, one should carefully distinguish between the long wave ultraviolet light (UV-A) and the short wave radiations (UV-B and UV-C). Ultraviolet A induces immediate pigmentation but, if high energies are applied, a permanent pigmentation is elicited. This type of ultraviolet A-induced pigmentation has been called "spontaneous" pigmentation as no erythematous reaction is necessary to induce or accelerate melanine formation. Ultraviolet B provokes erythema and consecutive pigmentation. Upon chronic exposure, ultraviolet B causes the wellknown actinic damage of the skin and even provokes carcinoma. With exposures to the sunlight (global radiation), one should be most careful. The public must be informed extensively about the dangers of excessive sunbaths. The use of artificial "suns" with spectra between 260 and 400 nm is limited as it may cause the same type of damage as the global radiation. An exact schedule for use of artificial lamps is strongly recommended. After one cycle of exposures, an interruption is necessary until the next cycle of irradiations may start. Upon continual use for tanning of the skin, artificial lamps may provoke irreversible damage of the skin. Radiation sources with emission spectra of wavelengths between 315 and 400 nm exclusively are well suited for the induction of skin pigmentation (cosmetic use). Potent radiation such as UVASUN systems provoke a "pleasant" permanent pigmentation after exposures for less than one hour. The use of ultraviolet A (UV-A) does not carry any risk for the human skin.

Amino Acids↗
PubMed1980

Nephrotoxicity of drugs, evaluated by renal enzyme excretion studies.

Via various pathways, urinary enzymatic activities are changed by drugs. Nephrotoxic effects may be determined by such investigations. Numerous experimental series have formed the basis for the clinical application of this method. The pertinent data collected with analgesics and antibiotics, alone or in combinations, are discussed in this paper. The data from the literature were compared with personal investigations, in animals as well as in man. It is concluded that - under certain precautions - the nephrotoxicity of drugs can be evaluated by renal enzyme excretion studies.

Analgesics↗
PubMed1980

[Increase in alkaline phosphatase activity in small intestine mucosa in high fat diets].

The activity of alkaline phosphatase in small intestine mucosa was increased by about 40% in rats adapted to a high fat diet in comparison to high-carbohydrate-adapted animals. As high fat-feeding leads to an increase in the intestine's capacity to absorb fat, this finding is consistent with the hypothesis that alkaline phosphatase in the small intestine epithelium plays a role in fat absorption.

Alkaline Phosphatase↗