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Biomedical subjects

W Sułkowski

Publications and source records attributed to W Sułkowski.

At least 19 recordsLinked to original sources
PubMed1992

[A case of unusual occupational allergy to bee venom].

The authors discuss an exceptional case of allergy to bee venom in a zoo-technician working on a morphological analysis of bees. During her work, the zoo-technician was repeatedly stung, initially with only small local reaction. After six-year period of work, the symptoms that followed stinging had all the characteristics of general oedema. Next years of exposure to bee venom resulted in collapse in the patient. Allergological examinations indicated work-related hypersensitivity to bee venom. The case history was supplemented with prophylactic recommendations. General principles of controlling the shock were provided.

Accidents, Occupational↗
PubMed1992

Auditory brainstem responses (ABR) in guinea pigs to loud tones noise: a preliminary study.

It is well known that exposure to intense acoustic stimuli can induce permanent damage to the tissues of the inner ear. In this study the technique of ABR measurement and the experimental animal model of acoustic trauma were presented. In forty 3 months old guinea pigs the hearing threshold was assessed using the ABR technique (Amplaid mk 10 system). The hearing thresholds ranged from 40 to 50 dB-pe-SPL (mean 45.26 dB, sd. 4.73). The mean latencies of the four most prominent peaks in the ABR pattern were also measured. Fourteen of animals were then exposed to a 1 kHz pure tone at different duration and stimulus level. The ABR threshold was measured immediately after exposure and 20 to 30 days later. The exposure at 112 dB for 2h caused the threshold shift in all guinea pigs varying from 25 to 65 dB. After 3-4 weeks of recovery time in all animals hearing threshold improved, in some animals reaching the pre-exposure level. We conclude that the ABR technique allows to measure precisely and with high reproducibility the hearing level in guinea pigs and also allows to estimate the threshold shift after exposure to noise.

Animals↗
PubMed1992

[A computerized system for the protection of the hearing of workers exposed to noise].

The periodical audiometric examinations carried out in order to identify persons with high susceptibility to acoustic trauma is very important in the hearing protection projects concerning workers occupationally exposed to noise. The authors present a computerized system which allows collection and analysis of the results of medical and audiometric examinations. Computer analysis of audiometric data helps to select and protect the workers with dynamic progression of hearing impairment. We believe that the hearing protection system we propose may improve medical care for the workers at risk.

Audiometry↗
PubMed1991

On the limitation of brainstem auditory evoked potentials for indication of susceptibility to noise.

The efficiency of Brainstem Auditory Evoked Potentials (BAEP) as an indicator of susceptibility to hazardous noise was investigated. In earlier studies, subjects were exposed to very intense occupational noise and temporary threshold shift (TTS) was produced by high intensity noise of 115 dB. Correlations between experimental TTS and the BAEP changes were investigated. BAEP indices, which significant correlations with the eventual hearing loss, were found. Similar criteria, which were found significant in the earlier work, were investigated in 94 industrial workers with normal hearing, without past exposure to noise, using a more moderate TTS-producing noise of 110 dB SPL. Under these conditions, no significant correlation between the noise susceptibility index and BAEP changes during TTS was found. The results of this study demonstrate the limitation of determining individual susceptibility to noise-induced hearing loss using BAEP. TTS-producing noise levels must be high enough. Their predictive value holds only for hearing losses typical of high intensity occupational exposures.

Adolescent↗
PubMed1991

Effects of noise on cognitive processes of individuals in a laboratory experiment.

The effects of noise on information processing in perceptual and memory tasks, as well as time reaction to perceptual stimuli, were investigated in a laboratory experiment. Performance and heart rate in Information Processing Test, Simple and Choice Reaction Time tests and Stroop's test were evaluated at three levels of noise (silence, 75 dBA, 95 dBA). Individual noise sensitivity and noise-induced temporary threshold shift (NITTS) were also assessed. The results show that neither noise nor individual noise sensitivity, or NITTS, as separate factors have an influence on information processing and time reaction to perceptual stimuli. However, noise effects simple reaction time in interaction with individual noise sensitivity, and information processing--within experimental session duration. Experimental session duration was the one separate factor affecting information processing. Noise as a separate factor does not have an influence on task performance, however, it affects heart rate. The higher increase of noise-induced temporary threshold shift, the smaller the number of heart beats/minute was found.

Adult↗
PubMed1990

Discrimination of slight changes in tone frequency applied in audiological diagnosis of noise-induced hearing impairment.

Investigations were carried out to examine the ability to differentiate low-grade changes in tone frequency in 58 subjects (116 ears) with noise-induced hearing impairment. The results were compared with those obtained in an age-matched group of healthy controls with normal hearing acuity. Statistically, the slight discrimination of frequency changes was found to be significantly worse in the group with noise-induced hearing impairment.

Adult↗
PubMed1990

The oxidative phenotype as a marker of individual predisposition to neoplasm induced by chemical carcinogens.

The authors present a review of literature showing that the variations in xenobiotic oxidation phenotype, in the presence of cytochromes P-450, may be responsible, to a certain extent, for the varied individual susceptibility to neoplasm induced by chemical carcinogens. The evidence collected revealed that in the human population, one may distinguish individuals with high cytochrome activity and those in whom this reaction is low or even absent.

Biomarkers, Tumor↗
PubMed1990

[Diseases of the upper respiratory tract in furniture industry workers].

A group consisting of 100 cabinet-makers (at average age of 44.6 +/- 12.8 years) employed at furniture manufacturing plants exposed to wood dust at concentrations exceeding several times (from 7 to 8 times) the hygienic standard was subject to examination. The higher, as compared to the data for general population, prevalence of chronic rhinitis , pharyngitis, laryngitis--among other--atrophic rhinitis and pharyngitis which occurred in 37% of examined population, increasing together with prolonging period of exposure was found. At the same time there have not been found any cases of allergy, nasal or nasal sinuses neoplasms which could be a result of exposure to wood dust.

Adult↗
PubMed1990

[Biochemical basis of the effect of organophosphate pesticides on humans].

The rapidly increasing use of organophosphorous compounds in everyday life causes that greater attention should be paid to the toxic effect exerted by these compounds on human organism. Acute toxic effects have been relatively well known whereas chronic effects require further studies. It is essential especially in view of progressive pollution of environment. The report presents data on the mechanism of action of organophosphorous compounds on human organism with particular regard to those effects which lead to the so called delayed neuropathy. The occurrence of that phenomenon as a result of single exposure to high concentrations of organophosphorous compounds as well as due to long-term exposure to the relatively low doses of those substances has been discussed.

Acetylcholinesterase↗
PubMed1989

[Bioactivation of xenobiotics by cytochrome P-448 and its role in the process of carcinogenesis].

The paper presents the general data concerning cytochrome P-448, as well as its participation in the formation of oxygen radicals and active metabolic intermediates, originated during xenobiotics' oxidation. Also, induction of synthesis of cytochrome P-448 (aromatic hydrocarbons hydroxylase), along with the role this phenomenon plays in the initiation of neoplastic process, are discussed.

Acetaminophen↗
PubMed1989

[Internal ear damage in vibration syndrome caused by local vibration].

Unlike with the vibration syndrome caused by general vibration whose clinical picture may exhibit internal ear impairments in the of hearing losses and vestibular disturbances, similar lesions in the vibration syndrome due to local vibration have not been confirmed explicitly. For better explanation of this issue, analysed were the results of audiometric and electronystagmographic (ENG) tests in a group of 40 otologically healthy++ men, in whom during 1986-1987 the angioneurotic vibration syndrome was diagnosed. The results were analysed considering subjects' age and duration of work in exposure; evaluation involved the increase in hearing thresholds for pure tones (audiometer Peters AP-6) and quantitative and qualitative changes in ENG records (electronystamograph Tonnies D-420 TS), calculating, among others, amplitudes and angular velocity of nystagmus slow phase. In 75% of subjects (30 persons) sensorineural hearing losses of different degree were found, mostly within the 3000-8000 Hz range, demonstrating a directly proportional dependence on the length of employment. Symptoms of vestibular disturbances in ENG records were detected in 57.2% (23) persons with marked predominance of the cases of vibration exposure over 10 years. The authors analyse mechanisms of the development of internal ear impairments in result of local vibration and concomitant noise.

Adult↗
PubMed1988

[Electrophysiologic studies of hearing: current methods in clinical and occupational audiology. I. Brain stem evoked response audiometry (ABR)].

Electrophysiological methods of auditory assessment called evoked responses are an exciting new development with broad implications in the fields of otology, audiology and neurology. At the present time they are the best objective non-invasive audiometric tests (versus subjective psychoacoustic examinations) for predicting hearing thresholds in infants and uncooperative patients. Basic concepts of electric response audiometry, most important auditory evoked potentials, their probable sites of generation and classification according to latency i.e. elapsed time between stimulus and response are reviewed. Instrumentation, procedure and technical considerations in recording the brain-stem evoked response audiometry (ABR), the most popular recent method for evoked potentials testing are described. Special attention is focused on measurement, identification and interpretation of brainstem responses and their major clinical uses, namely threshold testing of infants, young children and malingerers, diagnosis of acoustic tumors and neurological evaluation of brainstem lesions. Finally, the first own experience with a new employed in our laboratory the evoked potentials system Amplaid MK 10 for clinical testing of auditory pathways are presented and illustrated by some examples of application of brainstem audiometry in diagnosis of occupational noise-induced hearing loss.

Adult↗
PubMed1987

[Dosimetric evaluation of noise and results of the audiometric examination of a selected group of workers in the refinery-petrochemical industry].

Sonometric and dosimetric measurements of noise at a dozen workplaces of three divisions in a refinery-petrochemical plant have been made. The equivalent level allowable with a view to hearing protection was found to be exceeded by 1-3 dBA at some workplaces. The tonal audiometric test was used to determine threshold levels for 250-8000 Hz frequencies in 122 workers. The present acoustic conditions at the test workplaces do not pose a risk of a significant hearing loss. Only a slight high-frequency hearing loss which might result from noise exposure was diagnosed. Not a single case of occupational hearing impairment conformable with the mandatory diagnostic and certificatory rules was reported.

Adult↗
PubMed1986

[Epidemiology of occupational cancer of the upper respiratory tract in Poland 1971-1985].

Incidence of the occupational cancer of the upper respiratory tract has been assessed on the basis of analysis of the data from central register of the occupational disease recognized by the state sanitary-epidemiological service. 99 cases versus 374 all registered occupational cancers of different target organs were found, entirely in men of the mean age 53.6 +/- 6.8 years, and of mean exposure duration 21.3 +/- 8.3 years. The greatest number of cases concerned the workers employed in engineering (23.2%) metallurgical (18.2%) and chemical (14.1%) industry in age groups 50-59 years (55.5%) and duration 16-20 years and above (75.6%). Among carcinogens identified in the work environment, tars, soots and oils with content of polycyclic aromatic hydrocarbons (46.5%), chromium compounds (24.3%), "other" chemicals like ferric oxide, dichlorobenzidine, N-Phenyl-2-naphthylamine (9.1%), and asbestos (9.1%) have predominated in proportions given in brackets. In the major part of cases analysed in the study, the larynx was affected (86.9%), and only individual cancers were localized within oral cavity (7.1%), pharynx (4.0%), nose and nasal sinuses (2.0%). Finally, some general difficulties with identification of human environmental carcinogens, and with explaining possible associations between specific cancer sites and industrial chemicals action have been discussed.

Adult↗
PubMed1986

[A permanent noise-induced shift in the auditory threshold in textile industry workers].

Hearing thresholds have been measured in 236 cotton weaving mill workers (124 women: average age 42.5 +/- 11.2 years, average length of employment 19.5 +/- 10.6 years and 112 men: average age 41.2 +/- 10.3 years, average length of employment 19.0 +/- 11.1 years) exposed to continuous broadband noise of the constant level of approx. 100 dB-A. 90% of subjects exhibited the permanent threshold shift characterized by a great individual variability and maximum loss at the 4 kHz frequency. Those lesions were getting enhanced with increasing length of exposure and were more serious in elder age groups. No significant differences between the hearing loss intensity in men and women were found. The development of the hearing loss is characterized by its rapid increase within 3, 4 and 6 kHz during the initial 8 years of exposure, stabilization between years 9-12 and slow moderate increase within the further 13-31 years of exposure. Those conclusions should be implemented into practice through an increase in the frequency of preventive audiometric tests in the initial period of work in exposure which has such a great impact on the development of the hearing impairment.

Adult↗