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Biomedical subjects

W Vycudilik

Publications and source records attributed to W Vycudilik.

At least 55 records · Page 3Linked to original sources
PubMed1979

Gas-liquid chromatography of submicrogram amounts of drugs. V. Preparation of low-activity packed columns and their application to the toxicological analysis of underivatized polar drugs in the low nanogram range.

When diatomaceous earth and glass columns are acylated prior to coating with a silicone liquid phase, then subjected to heat treatment in an atmosphere of nitrogen, gas chromatographic columns can be prepared that show a marked reduction in adsorption. These columns can be used with a nitrogen-specific detector to chromatograph unmodified polar compounds such as morphine and cyclobarbital in nanogram amounts. Virtually no alteration of peak shape and no variation of retention time are observed over the range 10(-6)-10(-9) g of polar drugs. This represents, for these polar drugs, an "improvement" in chromatographic capability of the order of about 1000-fold in comparison with the best conventional commercial columns. Application to toxicological analysis of morphine in urine is described.

Barbiturates↗
PubMed1978

[Criminalistic aspects of iatrogenic air embolism (author's transl)].

With reference to 7 cases of iatrogenic air embolism examined by autopsies at the Vienna Institute of Forensic Medicine between 1968 and 1977, the most important causes of such complications are discussed. The wide-spread use of intensive therapeutic methods has led to the tendency that an increasing number of air embolic incidents happens during intravenous infusions. Four cases are reported: two of them occurred by incorrect handling of an automatic infusion pump; two further complications followed insertion or use of central venous catheters. Frequently outward circumstances refer to an air embolism even ante obductionem. In our cases the suspected diagnosis was based on the following signs: air filled venous catheters remaining on the body [3], striking manipulations on infusion apparatus [2], premortal X-ray film [1], typical clinical picture [1]. The analytical-chemical part deals with the infrared and mass spectroscopic investigation of adhesive residues. The traces, which were detected on the housing of an infusion pump, originated from an adhesive tape used to hold down a push button to turn off the warning device. Comparing the spectra of known adhesive tapes it was possible to adjoin the incriminated residues to the adhesive component of 'Normaplast'.

Adult↗
PubMed1978

[Acute self-poisoning with arsenic and treatment with BAL (author's transl)].

A case of attempted suicide by ingestion of 4.8 g As2O3 (more than 20 times the estimated lethal dose) is reported. Absorption of arsenic caused elevated urinary levels over 5 days BAL treatment was started within three hours after arsenic ingestion. The patient did not develop any signs of polyneuropathy or other clinical changes.

Arsenic Poisoning↗
PubMed1976

[The umbilical cord blood lead concentration: a comparison between an urban and rural population (author's transl)].

The cord blood lead level was determined to 40 newborn infants. The values were significantly higher in the infants born to mothers resident in Vienna than in the infants born to the group of mothers from the rural surroundings of Eisenstadt. The overall mean blood level was 17.7+/-7.4 mug/100 g. Increasing pollution requires investigations concerning possible effects on the growing fetus and would serve as foundation for future trend assessment studies.

Air Pollution↗
PubMed1976

[The ratio of the concentrations between the components of a two phase hypnotic in relation to the time of intoxication (author's transl)].

Two cases of poisoning with a double phase effect hypnotic were investigated in respect to the extent to which concentrations of short and medium acting barbiturates (hexobarbital, cyclobarbital) could be used for estimating the duration of poisoning. The analysis of brain turned out to be especially suitable. Increasing the duration of poisoning the ratio of the concentrations was shifted towards the longer acting component. Blood the liver seem to be less informative. The method might be used to estimate the interval between beginning of the poisoning and death in case of intoxication with different acting barbiturates.

Aged↗
PubMed1975

[Isolation of drugs from blood with macroreticular resins (author's transl)].

The use of Amberlite XAD resins for isolation of drugs from blood without preliminary precipitation of proteins is described. Compared with the usual methods of precipitation this method gives better yields and cleaner extracts in a shorter time. In combination with specific methods of detection, e.g. with GC and Nitrogen detector, the use of XAD promises to be efficient in the screening for drugs in the forensic and clinical field.

Adsorption↗