PubMed Health⌕ Search

Biomedical subjects

W Woźniak

Publications and source records attributed to W Woźniak.

At least 37 records · Page 2Linked to original sources
PubMed1998

A case of high origin of the common interosseous artery.

During autopsy dissection a high origin of the common interosseous artery was found. The artery originated in the upper one third of the arm and followed the course of brachial artery. It gave off muscular branches and radial as well as ulnar recurrent arteries, and in the distal part of the cubital fossa it divided into anterior and posterior interosseous arteries. The brachial artery passed medially to the median nerve, gave off superior and inferior ulnar collateral artery, and above the superior border of the pronator teres muscle divided into ulnar and radial arteries.

Aged↗
PubMed1998

[The analysis of failures in therapy of osteosarcoma in children treated according to SFOP-94 protocol in the studies of Polish pediatric solid tumors treatment group].

Between December 1989 and April 1998 twenty eight children aged from 5 to 20 years (18 female and 10 male) suffering from osteosarcoma were treated according to the OS-SFOP-94 protocol. Twenty four patients presented with localized tumor of extremities and four with pulmonary metastases. The majority of primary tumors exceeded 150 ml of volume. The primary preoperative chemotherapy consisted of adriamycin (70 mg/m2 every four weeks) and high-dose methotrexate (12 g/m2 every week). In 20 patients limb-salvage surgery was applied, in three children--amputation and in one child tibia resection with genu arthrodesis was applied. Five of 28 patients died, one because of treatment related infection, 2 non-responders with metastatic osteosarcoma due to progressive disease, and one because of local relapse with pulmonary metastasis non-responding to therapy, one because of treatment refusal. Twenty one from 25 children are alive from 5 to 51 months. Event frae survival of children with localized disease calculated according to Kaplan-Meier analysis was 64.17% in the 51st month. The main cause of failure in the treatment of osteosarcoma in children is primary and secondary progression of disease. The toleration and results of treatment for osteosarcoma in children according to the OS-SFOP-94 is satisfactory.

Adolescent↗
PubMed1998

Morphometric study of the human embryonic retina.

In 33 embryos the retinal thickness and neuronal density was investigated. Diameter of the eye in relation to embryonic age increases linearly to stage 20 and after this period is more pronounced. Thickness of the external nuclear layer increases slowly in the investigated period. The internal nuclear layer appears at stage 17 and in increases in thickness fourfold to the end of embryonic period.

Embryo, Mammalian↗
PubMed1997

Morphometric studies on the development of the human thyroid gland. II. The late fetal life.

Histological and morphometric studies were performed on 27 thyroid glands obtained from normal fetuses ranging between 23 to 40 weeks of intra-uterine life. In the thyroids the volume of gland, colloid, and stroma were calculated by means of differential pointcounting method and the height of the thyroid follicular cells was measured. Moreover, the epithelium/colloid ratio in the thyroid gland, a very sensitive parameter of stimulation of the glands by TSH, was calculated. Regarding the values of this ratio in human fetal thyroid gland, the intra-uterine development of the gland may be divided into three distinct stages. The first one, between weeks 10-18 is characterized by massive folliculogenesis and gradual accumulation of the colloid. The second stage, between weeks 19-29 of fetal life is characterized by rather unchanged values of epithelium/colloid ratio and the size of follicles. The third stage, after the 29th week of development is characterized by a gradual increase in the epithelium/colloid ratio and a decrease in the size of follicles.

Epithelium↗
PubMed1997

Comparative stereological study on zonation and cellular composition of adrenal glands of normal and anencephalic human fetuses. I. Zonation of the gland.

Comparative stereological studies were performed on zonation of adrenal glands in 10 anencephalic and 11 normal fetuses, aged between 24 and 39 postovulatory weeks. The development of adrenal fetal zone (FZ) is the main factor responsible for normal adrenal gland growth during the intra-uterine life. At the end of fetal period volume of this zone attains over 8200 mm3 and constitutes 69-70% of the total gland volume, while respective values for zona glomerulosa (ZG), zona fasciculata (ZF) and medulla (M) are 1665 mm3 (14%), 833 mm3 (7%) and 1071 mm3 (9%). These data were in striking contrast with those found in adrenals of anencephalic fetuses, in which volume of the gland attained only ca 35% of that in normal fetuses. In the oldest anencephalic fetus studied (39 weeks) the volume of the fetal zone was 962 mm3 (ca 8-folds lower than in normal fetus) comprising only 25% of the total gland volume. For the remaining zones the values were: ZG-1501 mm3 (ca 90% of the normal value and 39% of the total gland volume); ZF-770 mm3 (ca 92% and 20% respectively), and M-539 mm3 (ca 50% and 14%, respectively). This stereological study provides the first systemic description of the development of adrenal gland of anencephalic fetuses in comparison with the normally developing gland. Moreover, evidence is given that the growth of adrenal medulla is also retarded in anencephaly while the growth of the zona glomerulosa remains rather unaffected.

Abnormalities, Multiple↗
PubMed1997

Comparative stereological studies on zonation and cellular composition of adrenal glands of normal and anencephalic human fetuses. II. Cellular composition of the gland.

In our previous paper (Bocian-Sobkowska et al., 1997) we demonstrated a striking difference in development of zonation in adrenals of normal and anencephalic human fetuses. The purpose of the present study was to characterize, by means of stereology, the cellular composition of developing adrenals in the same case. Studies were performed on 11 pairs of adrenal glands from normal fetuses and 10 from anencephalic fetuses. In the studied period of development (24 to 39 weeks of intra-uterine life) the average volume of cells in normal glands increased as follows: zona glomerulosa (ZG) from 355 to 870 microns3; zona fasciculata (ZF) from 779 to 1200 microns3; fetal zone (FZ) from 2004 to 2380 microns3: and medulla (M) from 600 to 970 microns3. In anencephalic fetuses, the appropriate values were: ZG-380-680 microns3; ZF-460-680 microns3; FZ-1820-1680 microns3; and M-870-1400 microns3. At the end of the studied period the number of ZG cells in normal fetuses was two fold higher than in anencephalics, ZF cells-6-fold and in FZ-5-fold higher, while in the M the number of cells was nearly equal in both groups. During the whole investigated period of intra-uterine development the total number of adrenocortical cells in normal glands increased ca 2.5-fold, while in anencephalic glands only ca 0.5-fold, reaching at the end ca 40% of normal value. In both normal and anencephalic adrenals the number of ZG and M cells was highly correlated with ZG/M cell ratio, being slightly higher in normal glands. No such relation was demonstrated for cells of the remaining adrenocortical zones.

Abnormalities, Multiple↗
PubMed1997

Prenatal development of the human pancreatic islets. Immunocytochemical identification of insulin-, glucagon-, somatostatin- and pancreatic polypeptide-containing cells.

Histological studies were performed on 24 pancreases of normal human embryos and fetuses aged 7 to 38 weeks. For immunocytochemistry, the avidin-biotin-peroxidase method was used to identify and localize insulin, glucagon, somatostatin, and pancreatic polypeptide (PP) cells. In 7 wk old embryos, cells containing somatostatin and PP are observed. One week later appear single glucagon-positive cells. In the 9th wk, insulin producing cells are visible. During the fetal period two populations of the investigated cells are found: Langerhans islets and dispersed cells. The latter cells containing insulin, glucagon or somatostatin are localized in the walls of pancreatic ducts throughout the whole gland, while PP-positive cells are seen mainly in the part of the pancreas, which develops from the ventral anlage (anteroinferior part of the head and adjacent part of the main pancreatic duct). During the development of islets we have observed four stages: (1) scattered cells (7 to 10 weeks); (2) grouping cells (11 to 15 weeks); (3) mantle and zonular islets (10 to 29 weeks), in which B cells located inside are surrounded by a thick zone of A, PP and somatostatin-producing cells; (4) mixed islets (from 30 weeks on) - all cells are scattered over the whole transverse section of the islet. In the developing pancreas, the glucagon- and somatostatin-containing cells are the most numerous, while the insulin and PP-containing cells occur in lesser quantities.

Embryo, Mammalian↗
PubMed1997

Fine structure of the capillaries in the spinal cord of human embryos at 7th week.

Study were made in three human embryos at developmental stages 18 and 19 (7th week). It was shown that the wall of the capillaries is formed by one or two endothelial cells, which are separated by perivascular space from the glial cells. Endothelial cells possessed cilia projecting into the vascular lumen and are connected through the zonulae occludentes.

Capillaries↗
PubMed1997

Origin of the uterine artery in human fetuses.

Study was performed in 64 fetuses aged 9-40 weeks. In most of investigated fetuses (42 on the right side and 40 on the left side) the uterine artery arose separately from the internal iliac artery. It was also found that this artery originated as a common trunk with the pudendal, gluteal, middle rectal, and umbilical arteries.

Arteries↗
PubMed1997

Morphometric study of the lens in staged human embryos.

In 32 embryos of developmental stages 13 to 23 the measurements of the eye and lens were made. It was shown that the speed of growth of the eye and lens is at a maximum between 19 and 23 stages. Beginning from stage 19 the lens acquires ellipsoidal shape.

Embryonic and Fetal Development↗
PubMed1996

Malignant humeral bone tumors in children: excision and reconstruction with the use of rotated clavicle.

The application of intensive multimodality therapy has made possible salvage surgery in bone tumors. Reconstruction of the removed part of bone is the great problem, especially in fast-growing children. In three patients (two osteosarcomas and one Ewing's sarcoma), the tumor was confined to the proximal half part of humerus, without invasion of shoulder joint. After induction chemotherapy, reduction of tumor size was observed both clinically and radiologically. During the operation, wide resection of the tumor together with a 12- to 14-cm-long fragment of humerus, was performed. Afterward, the clavicle was rotated in the place of the removed bone, with preservation of the coracoacromial ligament. The humeral stump and clavicle were fixed with the use of metal plate. Adjuvant chemotherapy was used a few days following surgery. After 3 months, the osteosynthesis had healed. The movements in shoulder joint are limited, but functions of elbow joint remained normal. All children are alive and disease free. Reconstruction of humerus with clavicle rotation is possible when the proximal bone loss is not longer than 10-14 cm. This method seems to be an alternative to allogeneic grafts and endoprostheses.

Adolescent↗
PubMed1996

Origin and topography of the pelvic nerves in human embryos and fetuses.

The pelvic plexus is observed in human embryos at stage 15 and during the last two embryonic weeks the secondary plexuses are formed. The pelvic nerves are found at stage 15 and in embryos they arise from anterior rami of the sacral nerves S2-S4. In fetuses the pelvic nerves originate from the anterior rami S1-S5. Number of pelvic nerves from one anterior ramus varies from 1 to 3.

Embryo, Mammalian↗
PubMed1996

Sources of afferent fibers from the tongue muscles.

The afferent impulses from the tongue muscles are carried by the hypoglossal nerve, trigeminal nerve, and some of them by glossopharyngeal nerve. The main exit of afferent fibers constitutes the hypoglossal nerve. The location of the ganglion cells responsible for proprioceptive impulses are mainly in the spinal ganglia of the C1-C3 spinal nerves.

Animals↗