Timing of events during embryonic development of parathyroid glands.
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Biomedical subjects
Publications and source records attributed to W Woźniak.
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In embryos at stage 16 (37 days) the intramedullary roots of the spinal accessory nucleus ascend in the marginal layer of the spinal cord within one segment. These fibers form the intramedullary accessory fascicle of the XIth nerve. This fasciculus was observed in further developmental stages of investigated embryos.
Human thyroid gland was investigated in 6 embryos at stage 23. In 4 embryos, in the peripheral part of the thyroid gland, distinct follicles were observed. Some of them were filled with PAS positive substance.
The author presents the contemporary multimodality treatment in osteosarcoma in children and adolescents, taking into account salvage surgery and less mutilating surgery. Between 1962 and 1994, 158 osteosarcoma and 105 Ewing's sarcoma patients were treated in The Research Institute of Mother and Child. In these population 60 less mutilating operations were done. The comprehensive therapy influenced positively the results causing the increase of cure rate from 4.5% to 75% in osteosarcoma and from 4.3% to 41.3% in Ewing's sarcoma patients.
Basing on literature the role of subplate neurons in specification of cortical areas is described. These neurons are required for thalamocortical pathfinding and they form a crucial link in cortical target recognition.
The hypoglossal cord which is formed from occipital myotomes migrates rostrally to the future tongue. The hypoglossal nerve enters the hypoglossal cord which gives rise to the muscle of the tongue.
Investigations were made on serial sections of human embryos at developmental stages 16 and 17 (37-41 days). The spinal nucleus of the accessory nerve presents well delimited cellular group in the dorsplateral part of the ventral horn of the spinal cord. The migration zone is still present. In embryos of stage 16 the spinal accessory nerve joints the fibers originating from the nucleus ambiguous. This takes place at the level of the inferior ganglion of the vagus nerve. In stage 17 the secondary rami of the accessory nerve develop. This is correlated with the differentiation of the sternocleidomastoid and trapezius muscles.
The spinal part of the accessory nerve was investigated in serially sectioned human embryos at developmental stages 14 and 15. It has been recognized that the spinal accessory nucleus extends through the upper 4 or 6 cervical segments of the spinal cord. The nucleus is formed by group of cells lying dorsolaterally to the primordium of the ventral horn. There is no continuation of the cells forming the spinal nucleus of the XIth nerve with primordium of the nucleus ambiguus. Extramedullary roots of the spinal accessory nucleus form a long trunk ascending into skull and uniting with vagus nerve. In one embryo at stage 15 the spinal accessory nerve separates at the level of the lower ganglion of the vagus.
The ultrastructure of synapses in the pyramidal tract in the medulla oblongata have been described in a human fetus of 220 mm C.-R. length (23 postovulatory weeks). The mature synaptic junctions and the protosynapses were found above and at the level of the pyramidal decussation.
Olfactory nerve ensheathing cells (ONECs) were originally described as Schwann cells of the olfactory nerve. More recent studies have suggested that these cells express features of astrocytes, including the lack of basal lamina and collagen fibrils and the failure to ensheath axons individually. Recently performed experimental studies showed that ONECs from the olfactory bulb represent a novel glial cell type.
The number of mitral cells in layer III and IV was investigated in 8 olfactory bulbs removed from adult humans aged 21, 23, 41, and 42 years. This number was highest in male aged 23 years and in 41 and 43 years old specimens it decreased to the level found in 21 years old female.
In 1989 Leitbrock et al. reported the full primary structure of brain-derived neurotrophic factor. The messenger RNA for BDNF was found predominantly in the central nervous system, and the sequence of protein indicated its structural relation to NGF. BDNF belongs to a larger family of neurotrophic molecules. It stimulates the neurite outgrowth and supports neuronal survival.
The hypoglossal nucleus in embryos at stage 13 extends through the medulla reaching upper cervical segments of the spinal cord. It is formed by elongated group of cells in the ventral part of the basal plate. From the nucleus arise five thick roots which enter the occipital somites.
In embryos at stage 13th vestibulocochlear ganglion forms a complex structure with the geniculate ganglion. The geniculate ganglion is placed rostrally and may be distinguished from the vestibulocochlear ganglion. Also at this stage there is a sign of differentiation of the vestibular and cochlear ganglia.
Holter monitoring was performed in 55 patients (24 women, 31 men), mean age 50.7 +/- 11.3 who underwent ECG-triggered extracorporeal shock wave lithotripsy (ESWL). Patients were divided into two groups A--30 with history of cardiac disease and B--25 control. The heart rate was significantly higher before and after ESWL in the first group. The number of premature ventricular contractions was higher during ESWL in the same group. No other cardiac complication was observed.