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Biomedical subjects

W Woźniak

Publications and source records attributed to W Woźniak.

At least 109 records · Page 6Linked to original sources
PubMed1982

[Radioimmunological monitoring of the treatment of malignant neoplasms in childhood].

In 56 cases of children with tumours, the level of alpha-fetoprotein (AFP) was established with radio-immunological method. There were 15 children with neuroblastoma, 13 with ovarian tumours, 14 with sacro-coccygeal tumours, 7 with tumours of liver and 7 with tumours of testis. The level of AFP was elevated in all children with hepatoblastoma, carcinoma embryonale, and malignant teratoma. Monitoring was performed in 15 children with tumours mentioned above. Usefulness of evaluation of AFP level in blood serum in these tumours has been confirmed by diagnosis. In effective treatment of these tumours, AFP level has fallen down to normal. Its rising up again prognosed tumour's relapse several months before.

Bone Neoplasms↗
PubMed1981

Fine structure and myelination of the developing human vagus nerve.

The development of the cervical part of the vagus nerve was studied by electron microscopy in 17 human embryos and fetuses from 18 to 220 mm crown-rump (CR) length, approximately 7--23 postovulatory weeks old. By the end of the embryonic period proper, processes of neurolemmocytes are beginning to invade the nerve bundles of the vagus. Early in the fetal period, the nerve fibres become more regularly arranged, the lemmocyte/axon ratio is diminishing, the neurolemmocytes are dividing, and the connective tissue elements are becoming differentiated. By 14 postovulatory weeks (120 mm CR), examples of a 1:1 lemmocyte/axon ratio are observed, and the spiral development characteristic of myelination is beginning. By 17 weeks, myelinated fibres at varying phases of myelinogenesis are apparent, and desmosome-like junctions in the opposed plasma membranes are seen where lemmocyte processes form a mesaxon. By 23 postovulatory weeks, the diameter of the axons varies from 0.2 to 3.5 micrometer, and the vagus shows its mature structure, although nerve fibres at the beginning of myelin formation are still visible.

Desmosomes↗
PubMed1981

[Absolute indications for the surgical treatment of neoplasms in the neonatal period and its results].

The tumours of newborn period are usually of disontogenic origin and in some percentage of cases can be diagnosed directly after the child is born. Some of them are urgent for surgery. The authors present 22 own cases operated at the age of 4-28 days of life, in the period 1962-1977. Ten of them were sacro-coccygeal tumours. The indications for surgery were the following: tumours of morphological or clinical malignancies, big tumours disturbing motority of the child, tumours ruptured, bleeding, quickly growing and disturbed renal function. Positive result of the treatment was received in 80%. The authors suggest that cases have to be operated in highly specialized centres devoted to surgical treatment of malignant tumours in children.

Female↗
PubMed1980

Ultrastructural studies on differentiation of nerve cells in the human embryonic and fetal inferior ganglion of the vagus.

Inferior ganglia of the vagus nerve in human embryos and fetuses ranging in C.-R. length from 16 to 220 mm and in age from 7 to 23 weeks were studied by electron microscopy. During the investigated period of development 5 types of cells were distinguished, viz.: 1. primary (apolar) neuroblast, 2. early bipolar neuroblast, 3. intermediate bipolar neuroblast, 4. late bipolar neuroblast, and 5. unipolar neuroblast. The unipolar neuroblasts appear at the end of the embryonic period. In the 9th and 10th week of the fetal period the apolar and early bipolar neuroblasts disappear. In the 23rd week the neuronal cells of the vagus resemble those of adults. The maturation of neurons is associated with 1. structure of nuclear components, 2. cytoplasmic organization with special reference to the rough endoplasmic reticulum, 3. changes of cell shape and development of processes.

Cell Differentiation↗
PubMed1979

[Sacrococcygeal teratomas in children treated at the Oncological Clinic of the Mother and Child Institute in Warsaw].

During the years, 1962 through 1975, 27 children with sacrococcygeal teratomas were seen at the Oncological Department of the National Research Institute for Mother and Child in Warsaw. 13 teratomas were benign and 14 were malignant. Surgical removal through a sacral approach was the basis of the treatment. In the presacral tumors with great diameter two-phase method was performed (the first phase--trans-abdominal excision of the tumor and the second phase--excision of remnant tumor's pedicle with coccygeal bone resection). Monodrug chemotherapy (Cyclophosphamide, Actinomycin D) in malignant tumors was without effect. In the group of benign teratomas are alive 11 children, in the group of malignant teratomas only one child survived. Some profits are expected from the multidrug chemotherapy ( Methotrexate , Cyclophosphamide, Actinomycin D) associated with radiotherapy, this can make operable primarily inoperable tumors.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1979

Types of neural cells in the spinal ganglia of human embryos and early fetuses.

Spinal ganglial of human embryos and fetuses ranging in C.-R. length from 15 to 74 mm and in age from 6 1/2 to 11 postovulatory weeks were studied by light and electron microscopy. A sequence of events in differentiation and maturation enabled five types of cells to be distinguished: 1. apolar, undifferentiated neuroblasts are the main cells at 6 1/2 to 7 1/2 weeks; 2. early bipolar neuroblasts (strictly speaking, types 2 to 5 are immature neurons) predominate at the end of the embryonic period proper (8 postovulatory weeks); 3. intermediate bipolar neuroblasts are characteristic of the early fetal period; 4. late bipolar neuroblasts, in which two proceses arise separately from one pole of the cell, appear at about 10 postovulatory weeks; 5. unipolar neuroblasts are found within another week and, by that time, cells of types 1 and 2 are no longer present.

Cell Differentiation↗