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Biomedical subjects

Wojciech Pluskiewicz

Publications and source records attributed to Wojciech Pluskiewicz.

30 records · Page 2Linked to original sources
PubMed2003

The usefulness of quantitative ultrasound at the hand phalanges in the detection of the different types of nontraumatic fractures.

The aim of this retrospective study was to determine whether quantitative ultrasound (QUS) at the hand phalanges has the ability to discriminate between individuals without and with different types of nontraumatic fractures. All women (n = 2466) (age range 38-88 years) not affected by metabolic diseases or under treatment with drugs known to interfere with bone metabolism were divided into controls without fractures (n = 1883) and women with nontraumatic previous fractures (n = 583). Fractures were the result of minimal trauma involving a fall from a standing height or less during normal daily activity. Fractured group was divided into subgroups on the basis of the types of fractures: hip, spine, wrist or other fractures. Skeletal status was assessed using the DBM Sonic 1200 (IGEA, Carpi, Italy) which measures the amplitude-dependent speed of sound, Ad-SoS (m/s) in the distal metaphyses of the proximal phalanges of the second through fifth finger of the dominant hand. Women with hip, spine, wrist or other fractures had significantly lower Ad-SoS values than controls (1814 +/- 60 m/s, 1829 +/- 57 m/s, 1870 +/- 64 m/s, 1893 +/- 66 m/s, respectively, vs. 1943 +/- 73 m/s, p < 0.001). Ad-SoS revealed the following areas under the ROC curve: 0.91 +/- 0.027 for hip fracture, 0.89 +/- 0.019 for spine fracture, 0.77 +/- 0.012 for wrist fracture and 0.70 +/- 0.023 for other fractures. By multiple logistic regression analysis, the probability of having fracture, estimated as odds ratio for each 1 SD reduction in Ad-SoS, was: 3.49 (95% CI, 1.57-7.75) for hip, 3.25 (95% CI, 1.94-5.45) for spine, 2.24 (95% CI, 1.86-2.70) for wrist and 1.81 (95% CI, 1.36-2.40) for other fractures. The present study demonstrates the ability of phalangeal QUS to discriminate between subjects with and without different types of nontraumatic fractures. Phalangeal QUS revealed the best sensitivity and specificity in discriminating hip- and spine-fractured patients from controls.

Accidental Falls↗
PubMed2002

Quantitative ultrasound of the hand phalanges and calcaneus revealed skeletal abnormalities due to primary hyperparathyroidism: a case report.

Primary hyperparathyroidism (PHPT) is a common disease causing bone loss in elderly patients. We report a case study of a 36-year-old woman with PHPT. Quantitative ultrasound (QUS) assessment of the phalanges and calcaneus revealed significantly lower than normal values for age. This observation was confirmed by measuring bone mineral density in different skeletal sites using dual-energy X-ray absorptiometry (DXA). Subsequent parathyroid adenoma surgery normalized calcium metabolism, resulting in a progressive increase of BMD and ultrasound (US) parameters. This report has shown an ability of peripheral QUS examinations (phalanges and calcaneus) in early detection of bone alterations caused by PHPT in a young woman. Skeletal changes after surgery could be evaluated by QUS in a similar manner to that used in DXA.

Absorptiometry, Photon↗
PubMed2002

Quantitative ultrasound at the hand phalanges in monozygotic twins: a preliminary report.

The aim of this study was to assess the contribution of genetic and environmental factors on ultrasound (US) values within hand phalanges in monozygotic (MZ) twins. A total of 83 pairs of MZ twins (54 pairs of females, mean age 14.9 +/- 8.3 years, SD, and 29 pairs of males, mean age 14.1 +/- 7.1 years) and a control group consisting of 21 pairs of dizygotic (DZ) twins (14 pairs of females, mean age 13.9 +/- 6.9 years and 7 pairs of males, mean age 13.0 +/- 5.6 years) with no reasons for potential influence on bone metabolism were studied. Skeletal status was assessed using DBM Sonic 1200 (IGEA, Carpi, Italy) which measures at the hand phalanges amplitude-dependent speed of sound (Ad-SoS, m/s). The intrapair correlation coefficients of Ad-SoS values were in MZ pairs 0.96 for males, 0.98 for females and, in DZ pairs, 0.92 and 0.93, respectively (p < 0.0001). The intrapair correlation coefficients for Ad-SoS were significantly stronger in MZ pairs in comparison to DZ pairs (Fisher's test, p < 0.05). To study the hypothesis that the intrapair differences in Ad-SoS are connected with environmental factors, a simple linear regression analyses of absolute differences in Ad-SoS values with age were performed. In MZ pairs, increasing age was connected with significantly greater intrapair differences in Ad-SoS (for males r = 0.37, p < 0.05 and, for females, r = 0.32, p < 0.05). The results of multivariate linear analysis by using intrapair differences in Ad-SoS in MZ pairs as a dependent variable and age, weight and height as independent variables, showed that intrapair difference in Ad-SoS was influenced only by age, and not by weight, height, or intrapair differences in weight or height, for both males and females. The study provides the support for a significant contribution of heredity to skeletal status in MZ twins, although significantly greater intrapair differences in Ad-SoS with age suggest also the importance of environmental factors.

Adolescent↗
PubMed2002

Prediction of the biomechanical properties of cancellous bone using ultrasound velocity and bone mineral density--an in vitro study.

BACKGROUND: Recent experimental studies have suggested that the combination of DXA (dual energy X-ray absorptiometry) and ultrasound (US) measurements could improve the prediction of bone strength. The aim of this study was to investigate the ability of bone density and US velocity, measured by the phalangeal US system, to predict the Young's modulus and strength of cancellous bone. MATERIAL/METHODS: 35 cubes of bovine cancellous bone from the distal radii were prepared using a diamond cutting saw. The US velocity (Speed of Sound - SoS [m/s]) was measured for the three orthogonal directions (proximal-distal - PD; anterior-posterior - AP; medial-lateral - ML) using a DBM Sonic 1200 device (Igea, Italy). Bone mineral density (BMD [g/cm2]) was measured by DXA, as well as the apparent volumetric BMD (v-BMD [g/cm3], as the ratio of BMD to sample thickness). Young's modulus (E[MPa]) and ultimate strength (s[MPa]) were measured in the PD and AP directions by the uniaxial compressive test. RESULTS: The SoS and biomechanical parameters were significantly higher (p<0.0001) for the PD direction than for horizontal directions. In the PD direction, SoS, BMD and v-BMD correlated significantly with E (r=0.79-0.84, p<0.001) and s (r=0.68-0.80, p<0.01). In the AP direction, SoS and v-BMD correlated significantly (r=0.75-0.77, p<0.05) and BMD correlated almost significantly (r=0.66, p=0.05) with s, whereas their correlations with E were nonsignificant. In the PD direction, the predictive value of SoS or bone density alone for E and s was generally weaker than in the case of the combination of SoS with BMD or v-BMD (63-70% and 46-64% vs. 75-79% and 59-64%, respectively), as was also the case for the AP s (43-60% vs. 66-70%). CONCLUSIONS: The knowledge of both the US velocity and bone density improves the prediction of the biomechanical properties of cancellous bone.

Animals↗
PubMedDate not supplied

The ability of quantitative ultrasound at the calcaneus to identify postmenopausal women with different types of nontraumatic fractures.

The aim of the cross-sectional study was to determine if ultrasound (US) measurements of the calcaneus have the ability to predict the risk for fractures and to discriminate between postmenopausal women with and without different types of nontraumatic fractures. All women (n = 1,129, age range 40 to 87 years) were divided into group 1, created by 656 women with 956 nontraumatic past fractures, and group 2, consisting of 473 women without fractures. Group 1 was divided into subgroups: with hip fractures, with vertebral (nonhip) fractures, with wrist (nonhip and nonspine) fractures and with other (nonhip, nonspine and nonwrist) fractures. The speed of sound (SOS; m/s) and broadband ultrasound attenuation (BUA; dB/MHz) were measured with the Achilles system (Lunar), which also calculates stiffness index (SI; %). US values were significantly lower in group 1 (1,481.4 +/- 20.2 m/s, 98.7 +/- 9.4 dB/MHz, 61.1 +/- 11.0%; p < 0.000001) and in subgroups (p < 0.000001), and these women had a higher mean age and longer postmenopausal period than women without fractures (1508.2 +/- 26.5 m/s, 107.7 +/- 9.9 dB/MHz, 74.2 +/- 13.0%). Women with hip fractures had the lowest US values (1464.6 +/- 18.6 m/s, 89.9 +/- 8.7 dB/MHz, 50.6 +/- 10.5%), women with vertebral fractures had intermediate values (1473.6 +/- 17.4 m/s, 94.8 +/- 8.9 dB/MHz, 56.4 +/- 10.0%), and women with wrist (1,484.3 +/- 19.8 m/s, 99.9 +/- 9.3 dB/MHz, 62.7 +/- 10.7%) and other fractures (1,483.3 +/- 21.0 m/s, 100.4 +/- 8.6 dB/MHz, 62.7 +/- 10.6%) had the highest values. The US values differed significantly between subgroups with fractures (p < 0.05), with no significant differences between women with wrist and other fractures. ROC analysis showed SOS to have the best sensitivity and specificity in detecting fracture cases. All US parameters revealed the greatest areas under the ROC curve (AUCs) for hip fracture (0.92 to 0.93) in comparison to smaller AUCs for vertebral fractures (ranging from 0.84 to 0.87), and the smallest AUCs for wrist and other fractures (ranging from 0.72 to 0.77 and 0.72 to 0.78, respectively). Generally, the SOS measurement presented greater odds ratio (OR) than BUA and SI: 4.1 (3.09 to 5.43) for any fracture, 11.66 (3.09 to 43.96) for hip fracture, 6.51 (3.61 to 11.73) for vertebral fracture, 3.32 (2.41 to 4.58) for wrist fracture and 4.2 (2.7 to 6.54) for other fracture. The present study demonstrates the ability of calcaneal QUS to discriminate between healthy individuals and subjects with different types of nontraumatic fractures. Calcaneal US parameters show the best sensitivity and specificity in discriminating the hip fracture patients from the controls. Generally, the SOS parameter is a better discriminator than SI and BUA and estimates the highest OR for fractures.

Adult↗