Biomedical subjects

X Fu

Publications and source records attributed to X Fu.

218 records · Page 13Linked to original sources

PubMedDate not supplied

A metastatic orthotopic-transplant nude-mouse model of human patient breast cancer.

We report here the development of an orthotopic-transplant model of human patient breast cancer in nude mice. Histologically-intact patient breast tumor tissue was transplanted as intact tissue to the mammary fat pad of nude mice where the tumor tissue grew extensively and metastasized to the lung. This is the first orthotopic-transplant metastatic model of human breast cancer. The potential clinical and basic-science uses of the model are discussed.

Animals↗

PubMedDate not supplied

Human ovarian carcinoma metastatic models constructed in nude mice by orthotopic transplantation of histologically-intact patient specimens.

We report here the first orthotopic transplant model for human ovarian cancer. Histologically-intact patient specimens of ovarian cancer were transplanted by microsurgical techniques under the capsule of the nude mouse ovary. The human tumors grew locally and gave rise to a patient-like metastatic pattern including the parietal peritoneum, colon, omentum, and ascites. The orthotopic model described here should be useful for evaluating new therapeutics and diagnostics for ovarian cancer.

Animals↗