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Y Adachi

Publications and source records attributed to Y Adachi.

At least 865 records · Page 48Linked to original sources
PubMed1979

[Deep Sylvian psammomeningioma, report of a case (author's transl)].

The authors reported a case of 31-year-old female who had episodes of fainting attack. She had no significant neurological deficit but had EEG abnormality. Carotid angiography showed a tumor stain, ca. 1.7 cm in diameter, near the right insula. CT scan also revealed a high density area at the same site. At the time of operation, a small tumor located deeply in the right sylvian fissure was found out and successfully removed. Histologically, this tumor was diagnosed as a meningioma having some typical psammomatous features. This type of meningioma, named as deep sylvian psammomeningioma dy Cushing and Eisenhardt, is extremely rare; we could found only 19 cases in the literature.

Adult↗
PubMed1979

Comparison of antigenic properties among various strains of Treponema hyodysenteriae.

Agglutinin-absorption and precipitin-absorption studies demonstrated that three strains of Treponema hyodysenteriae isolated from cases of swine dysentery were antigenically different from each other and also from a spirochete isolated from a clinically normal dog. Each of the strains of T. hyodysenteriae also possessed two common antigens.

Animals↗
PubMed1978

Effect or oral administration of propylene glycol on the induction of enzymes and proteins in microsomes and cytosol of the rat liver.

Male Wistar rats were divided into 4 groups, receiving water, propylene glycol (PG), sodium phenobarbital (PB) and PB + PG, respectively. After oral administration of these materials for 7 days, various enzymes in hepatic microsomes and the binding capacity of Y and Z fractions in the cytosol were assayed. As compared with the water group, the aniline hydroxylase activity, the cytochrome b5 content and the amount of Z fraction increased in the PG group. As compared with the PB group, the microsomal protein increased but the activities of paranitrophenol-UDP-glucuronyltransferase (pNP-GT) and aminopyrine demethylase (AD) decreased in the PB + PG group. When the PB + PG group and the PG group were compared with the PB group and the water group respectively, there was no parallel change. Even though PG added to hepatic microsomes of untreated rats in vitro, there was no change in the difference spectrum produced by binding of cytochrome p-450 and aniline and also in the activities of AH and pNP-GT. Based on these observations, it can be concluded that PG affected the in vitro assay data of drug-metabolizing enzyme without changing the cytochrome P-450 content by its certain in vivo action rather than by its direct interaction with microsomes, and modified the effect of PB on the microsomal enzymes and the cytosol proteins. Therefore, it is not appropriate to investigate the effect of the drugs on enzymes and proteins of the liver cell by the use of PG as a solvent.

Administration, Oral↗
PubMed1978

Nature of antigenic determinant of serovar-specific antigen of Leptospira interrogans serovar hebdomadis.

The nondialyzable delipidized serovar-specific main antigen (NDTM antigen) of Leptospira interrogans serovar hebdomadis strain Hebdomadis (a variant which can grow in a synthetic medium) showed a strong inhibition of the complement fixation between the serovar-specific main (TM) antigen of this strain and the homologous antiserum. The inhibitory effect of the NDTM antigen was completely lost by treating the antigen with proteolytic enzymes, and the fractions of TM antigen containing amino sugar, neutral sugars, and lipids did not show any inhibition of complement fixation, indicating that the antigenic determinant of this strain is related to proteins. NDTM antigen contained more hydrophilic amino acids than hydrophobic amino acids, whereas TM antigen contained more hydrophobic amino acids than hydrophilic amino acids. The amino acid compositions of NDTM antigens of hebdomadis strain Hebdomadis (variant) and kremastos strain Kyoto, which belonged to the same serogroup, were considerably similar. Difference was found in the amounts of methionine, arginine, lysine and glutamine acid.

Amino Acids↗
PubMed1978

Studies of antigenic variants of leptospira isolated from experimentally infected mice.

Antigenic variants were isolated from mice inoculated with a virulent strain of Leptospira interrogans serotype copenhageni by cultivating the kidney cortex in the liquid or the solidified serum media containing the immune serum against the parent strain. The variants, which were isolated from the mice from 7 to 113 days after infection, were found to be antigenically different from the parent by the agglutinin-absorption test, precipitin-absorption test in gel and guinea pig protection test. The variants were antigenically stable and different from the 18 serotypes of the Icterohaemorrhagiae serogroup. The significance of antigenic variants of leptospira which appear in vivo is discussed.

Animals↗
PubMed1977

Identification of some Japanese leptospiral strains as serotypes copenhageni and icterohaemorrhagiae by preciptin-absorption test in gel.

Nine strains of Leptospira belonging to the Icterohaemorrhagiae serogroups isolated in Japan were identified by the precipitin-absorption test in gel. The results of the precipitin-absorption test matched closely with those of the agglutinin-absorption test. Two strains were identified as serotype copenhageni and 7 were serotype icterohaemorrhagiae. Strain Shibaura, which was thought to belong to serotype icterohaemorrhagiae and used in many laboratories in Japan, was corrected as belonging to serotype copenhageni.

Agglutination Tests↗
PubMed1976

Influence of drugs and chemicals upon hepatic enzymes and proteins. II. The effects of various barbiturates on the induction and reduction of hepatic cytoplasmic organic anion-binding proteins.

The effects of seven barbiturates (phenobarbital, three N-phenylbarbiturates and three N-cyclohexylbarbiturates) on the hepatic cytoplasmic organic anion-binding proteins, Y and Z, were investigated in an attempt to observe the structure-activity relationship of baributrates to induction and reduction of these two proteins. Sulfobromophthalein (BSP) was fully bound by the Y and Z proteins at ten minutes of mixing with the 10,5000 X g supernate. In low concentrations of BSP, saturation of binding of BSP by the Z protein was very low, and with increasing concentration, BSP-binding by the Z protein increased rapidly. The Y protein bound BSP sufficiently even in low concentrations of the dye. BSP-binding capacity of the Yprotein was increased by phenobarbital, phetharbital and bucolome, and decreased by one of the N-phenylbarbiturates. BSP-binding capacity of the Zprotein tended to be decreased by phenobarbital and phetharbital, but to be increased by bucolome. The other N-phenyl- and N-cyclohexylbarbiturates had no effect on the binding capacities of the two proteins. From these results it was concluded that the regulation by the barbiturates of cytoplasmic proteins is different from that of the microsomal enzymes, and that both type and structural relation are important in the induction and reduction of the Y and Z proteins.

Animals↗
PubMed1976

The discrepancy between plasma clearance tests of indocyanine green (ICG) and sulfobromophthalein (BSP): --report of cases and a study of ICG-binding pattern of serum proteins.

Two cases of Gilbert's syndrome and three cases of other diseases showed abnormally low plasma indocyanine green (ICG) clearance as contrated with normal or nearly normal plasma sulfobromphthalein (BSP) clearance. To evaluate the role of serum proteins in pathogenesis of these cases, ICG-binding patterns of serum proteins of the patients were compared with that of normal persons by the method of Sephadex G200 column chromatography. No qualitative differences in binding patterns were observed between serum proteins of the patients and normal persons. From these results, serum proteins were thought to be minor determinants of the hepatic ICG uptake mechanism. Because of normal or nearly normal plasma BSP clearance in these patients, the contents of hepatic organic anion-binding proteins, Y and Z, were thought to be sufficient. Possible qualitative abnormalities of the Y and/or Z proteins were also discussed.

Adult↗