PubMed Health⌕ Search

Biomedical subjects

Y Azuma

Publications and source records attributed to Y Azuma.

At least 199 records · Page 11Linked to original sources
PubMed1984

Indomethacin augments inhibitory effects of interferons on lymphoproliferative response.

Lectin-induced lymphoproliferative response was enhanced by the addition of indomethacin to the culture and in contrast, suppressed by the addition of interferon. However, when indomethacin and interferon were concomitantly present in the lectin-driven cultures, the suppressive effect of interferon on the lymphocyte blastogenesis surpassed the enhancing effect of indomethacin on the response. Furthermore, and unexpectedly, the inhibitory effect on the response due to interferon was definitely augmented in the presence of indomethacin as compared with the response in the absence of indomethacin.

Drug Synergism↗
PubMed1982

HLA-DR antigens in Japanese with Hashimoto's thyroiditis and Graves' disease.

HLA-A, -B, -C and -DR specificities were determined to study the association of HLA in 49 unrelated patients with Hashimoto's thyroiditis and 51 patients with Graves' disease. The results were compared with 144 control subjects from the Japanese population at large. Much less HLA-DR2 was found in the patients with Hashimoto's thyroiditis than in the normal controls. It was present in 16% of the thyroiditis patients compared to 39% in the controls. Also the frequency of HLA-DRl was less in the patients with Graves' disease (0%) than in the controls (15%). No positive association was found for any HLA-antigens in the two diseases.

Asian People↗
PubMed1980

[Pharmacological studies on rat passive cutaneous anaphylaxis (PCA) (author's transl)].

A study was made of the PCA reaction in rat hind paw for analysis of the mechanisms of the of the anaphylactic release of mediators in vivo. Also studied was the function of cyclic AMP in the anaphylactic release of histamine during PCA induced in rats with homologous and heterologous antibody. A close correlation was seen among edema formation, histamine release and decrease of cyclic AMP during homologous and heterologous PCA. Theophylline, epinephrine and isoproterenol increased the cyclic AMP level and strongly inhibited edema formation and histamine release, in all animals. Aminopyrine and trasylol also increased the cyclic AMP level but aminopyrine did not inhibit either edema formation or histamine release in case of heat labile homocytotropic antibody induced PCA in rats and trasylol did not inhibit histamine release in any animal. Methysergide and mepyramine strongly inhibited histamine release but did not alter cyclic AMP levels. Thus, the increase of the cyclic AMP level did not always inhibit the histamine release during PCA in rats. It has also been demonstrated that the PCA reaction in rat hind paw is a suitable model for studying the mechanisms of the anaphylactic release of mediators in vivo.

Aminopyridines↗