Female Sprague-Dawley rats aged 50 days received 3 intravenous injections of N-nitroso-N-methylurea, 5 mg/100 g of body weight at 4 weekly intervals. When the first palpable mammary tumours appeared, with an incidence of 50 to 60% after the third injection, rats were randomized into 8 groups: group 1 was treated with 17 beta-estradiol; group 2 received progesterone; group 3 received in association 17 beta-estradiol + progesterone; group 4 was treated with tamoxifen. In group 5, rats received ovine prolactin. In groups 6 and 7, female rats were bred. Group 8, as a control group, received no hormonal treatment. Other control groups of 8 rats aged 140 days were made up of rats receiving 17 beta-estradiol alone (group 9) and rats receiving only ovine prolactin (group 10). The last group was kept without any treatment (group 11). The incidence of mammary tumours was followed in groups 1 to 8. All pituitary glands and mammary tumours were removed and weighed when rats were sacrificed after the last hormonal injection in each group. Light microscopy allowed the anatomopathologist to classify all removed mammary tumours in each group as adenocarcinoma. Light and electron microscopies with all pituitary glands in groups 1 to 11 showed no abnormality. The distribution of the pituitary weights was between 4.0 to 6.8 mg per 100 g of body weight. No adenomas were detected in the pituitary glands of the 5-month-old Sprague-Dawley rats receiving N-nitroso-N-methylurea.

Adenocarcinoma↗

PubMedDate not supplied

[Pulmonary embolisms revealing visceral cancer].

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Adult↗

PubMedDate not supplied

[State of the bronchi in pulmonary diseases related to organic dust inhalation].

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Antigen-Antibody Reactions↗

PubMedDate not supplied

[A case of solid tumor of the small omentum (author's transl)].

With regards to an observation of a solid tumor of the small "epiploon", the authors recall the exceptionnal character of the primitive small tumors of the "mesenterium". Such cases pose a histological problem because, when dealing with the "mesenterium", the various criteria for benignity or malignity are difficult to appraise due to the peculiar tissue structure. A pre-operative-selective "arteriogram" cannot be dispensed with this type of tumor. Outside of the diagnostic possibilities offered, this "arteriogram" will be the basis for the treatment given since the possibilities of removal are limited by the connection between the tumor and the vessels. Furthermore due to the histological difficulties posed by these tumors it is desirable to treat them as potentially malignant material and include the removal, even if limited, of the corresponding digestive segment.

Aged↗

PubMedDate not supplied

[Report of eight aglomerular segmental renal hypoplasia in adult (author's transl)].

A radiological aspect of segmental hypoplasia of the kidney was found on intravenous urography of eight patients. Urography was performed five times for arterial hypertension, two times for proteinuria and one time for pathological pregnancy. Aglomerular segmental hypoplasia was constantly observed on histological examination, and in three cases an important follicular ureteritis was found. Medical treatment and unilateral nephrectomy greatly improved clinical symptoms of six cases.

Adult↗

PubMedDate not supplied

[Extraskeletal Ewing's sarcoma. Anatomo-clinical study of a new case].

A case of extraskeletal Ewing's sarcoma arising in right lumbar region with involvement of epidural space is described in a 16 years old girl. The diagnosis of Ewing's sarcoma was done from cytochemical and electron microscopic studies which showed intra-cellular glycogen granules whereas cytologic and immunological analysis eliminated lymphoid malignancies. This case emphasized the interest of these techniques, adjunctive to routine light microscopic examination for the pursuit of a specific diagnosis in the small round cell neoplasm.

Adolescent↗

PubMedDate not supplied

[Ultrastructure of bronchial biopsies obtained by fibroscopy during a remission between crises in asthmatic adults].

This study describes the ultrastructure of bronchial biopsies from ten patients with bronchial asthma in remission. The superficial submucosa was the seat of a cellular infiltration: the plasma-cells are the most numerous. Light microscopy shows thickening of bronchial basement membrane. By electron microscopy, the basement membrane appears intact and the thickness consists of collagen fibrils in plexiform arrangement. The epithelium shows goblet cells and basal cells hyperplasia and lesions of the ciliated cells. The defects in the ciliary ultrastructure are: compound cilia, abnormal cilia and internalized cilia. They can be regarded as non specific lesions. Two types of cells infrequent in the bronchial mucosa are found: one characterized by apparition of a dictyosome with mucous secretion; the second by defects of the cellular membrane and little electron dense cytoplasm. These two types of cells show a "mitochondrial barrier" like the ciliated cells. This study reveals that numerous lesions are seen in the bronchial mucosal of patients with severe asthma even in remission.

Adult↗