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Biomedical subjects

Y Frances

Publications and source records attributed to Y Frances.

45 records · Page 3Linked to original sources
PubMed1983

[Arterial hypertension induced by a nasal decongestant. Value of the use of an automatic and programmable recording technic].

The case of a twenty-three-year-old woman with spasmodic coryza in whom the overuse of a nasal decongestant resulted in arterial hypertension is reported. The relationship between the treatment and the occurrence of hypertension is firmly established. The original feature of this case is the use of the technique for monitoring the blood pressure and heart rate, before and after the treatment had been discontinued, which ascertained the hypertension, making it appear as an experimental model.

Adult↗
PubMedDate not supplied

[Study of the placebo effect by the pressure profile method].

The effect of one tablet of placebo daily for 8 days on blood pressure was studied in 90 hypertensive patients, using the blood pressure profile method, with a 12-hour recording period (from 8 a.m. to 8 p.m) and readings every 15 minutes (Dinamam 845). Statistical analysis of the results showed no significant difference in diastolic, systolic and mean blood pressure in 50% of the cases. A significant decrease of about 10% in blood pressure without change in variability was observed in more than 20% (complete placebo effect) and in about 30% (total placebo effect) of the cases. A significant increase of about 8% on blood pressure was recorded in less than 20% of the cases. Almost 25% of the patients had a significant decrease in heart rate. There was no correlation between heart rate and blood pressure under placebo. These criteria, which are both qualitative and quantitative, can be taken as reference when the blood pressure profile method is used to evaluate the effectiveness of antihypertensive drugs.

Antihypertensive Agents↗
PubMedDate not supplied

[Double blind randomized comparative study of two antihypertensive combinations. Enalapril-hydrochlorothiazide versus enalapril-nifedipine in 240 hypertensive patients resistant to monotherapy].

The combination of two antihypertensive drugs is recommended when mild to moderate hypertension is not controlled by sequential monotherapy. The aim of our study was to compare the efficacy and the safety of the combination enalapril 20 mg-hydrochlorothiazide 12.5 mg to that of enalapril 20 mg-nifedipine SL 20 mg x 2. Two hundred and forty four hypertensive patients not controlled (DPB > 95 mmHg) by a single dose of enalapril 20 mg/24 h, received for 4 weeks, one of these two combined therapies in a randomized double-blind trial. The efficacy was of same amplitude in the two groups (DBP: -10.8 mmHg enalapril-hydrochlorothiazide vs-10.3 mmHg enalapril-nifedipine). The side effects were less frequent in the enalapril-hydrochlorothiazide group (14 per cent vs 24 per cent, p = 0.04).

Adult↗