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Y Fuse

Publications and source records attributed to Y Fuse.

At least 109 records · Page 6Linked to original sources
PubMed1986

Enhancement of cyclic adenosine monophosphate content in bone cells by the factor extracted from a pancreatic cancer associated with hypercalcemia.

A woman with exocrine pancreatic cancer presented a syndrome of humoral hypercalcemia of malignancy (HHM). Either urea extract or acid/ethanol extract of the tumor showed a dose-dependent activity to elevate cyclic adenosine monophosphate (AMP) level in rat bone cells in primary culture. When each population obtained by the sequential digestion of rat fetal calvaria was cultured individually and cyclic AMP responses to parathyroid hormone (PTH), calcitonin, and tumor extract were examined, tumor extract-sensitive cells showed a similar distribution to PTH-sensitive cells. Tumor extract and PTH, but not calcitonin, increased cyclic AMP in osteogenic cell line MC 3T3-E1. PTH receptor-mediated increase of cyclic AMP was indicated by an antagonistic action of PTH analogue, (3-34) hPTH, on increase of cyclic AMP in MC 3T3-E1 elicited by tumor extract. Human breast cancer derived cell line MCF-7 had calcitonin-sensitive adenylate cyclase, but neither PTH nor tumor extract increased cyclic AMP in the cells. On Bio-Gel P-60 column, the activity to stimulate bone cell cyclic AMP was eluted as a single peak at the molecular size between 6.5 K and 12.4 K. It was concluded that pancreatic cancer, although rather exceptional as a cause of HHM, produced a factor very similar to that reported in representative HHM tumors of human and animal models.

Animals↗
PubMed1986

The pituitary as a target of antalgic treatment of chronic cancer pain: a possible mechanism of pain relief through pituitary neuroadenolysis.

Surgical hypophysectomy performed in 18 cases with hormone-dependent carcinoma resulted in tumour regression in 38.8% of the cases, and pain relief in 88%. Neuroadenolysis performed 170 times on 130 cases resulted in pain relief in 94% with hormone-dependent carcinoma, and 70% with non-dependent carcinoma. The clinical investigations, following performance of neuroadenolysis, indicate suppressed pituitary function, significant increase of ACTH, thyrotropin-releasing hormone and vasopressin in the cerebrospinal fluid (CSF), delay of long latencies in somatosensory evoked potential and increased pain threshold of C-fibres. Increase of beta-endorphin in CSF was very brief. Though the exact physiological activity in pain sensation of those peptides other than endorphins still remains obscure, increase of the peptides which are mainly synthesized in the hypothalamopituitary axis, along with suppressed pituitary function, is considered to exert a long-lasting suppressive effect on the mediation and perception of cancer pain through C-fibres and the central nervous system.

Endorphins↗
PubMed1986

[Cardiac angiosarcoma with gastrointestinal bleeding, hypoxemia, thrombocytopenia and microangiopathic hemolytic anemia].

This report describes cardiac angiosarcoma in a 62-year-old man. The patient presented with metastatic pulmonary and extradural spinal cord tumors of unknown origin. During the course, he developed hypoxemia, gastrointestinal bleeding, thrombocytopenia, and microangiopathic hemolytic anemia. Anticancer therapy could not be initiated because of his poor general condition, and he died. Autopsy revealed angiosarcoma in the right atrium. Metastases were found in the lungs, liver, adrenals, gingiva and vertebrae. The various hematologic abnormalities were probably the result of aberrant hemodynamics caused by the presence of a large amount of neoplastic vascular tissue.

Anemia, Hemolytic↗
PubMed1986

[A study of blood coagulation and fibrinolysis in a small-for- gestational-age infant birth group].

In order to approach from the aspect of blood coagulation and fibrinolysis the reason for the birth of SGA (small for gestational age) infants, we studied the blood coagulation and fibrinolysis capacity of maternal venous blood in the 36th and 37th weeks after conception employing 54 cases in which were no abnormality was seen during pregnancy up to delivery, and we also studied the relationship of the body weight at delivery and arrived at the following conclusions. In the SGA infant birth group there was a tendency toward acceleration of blood coagulation, acceleration of blood platelet aggregation and inhibition of fibrinolysis when compared with two other groups i.e. AGA (appropriate for gestational age) and LGA (large for gestational age) infant birth groups. In the SGA infant birth group in particular there was seen a statistically significant reduction in prothrombin time (p less than 0.002) when compared with the other two groups. A correlation was noted between prothrombin time for maternal blood and the infant's body weight at birth (r = 0.38446, p less than 0.01), and the shorter the prothrombin time for maternal blood in the late stage of pregnancy, the lower the infant's body weight tended to be at birth. The results indicate that these changes in blood coagulation and fibrinolysis may influence the decrease in the blood output of the uterine placenta, and it may be assumed that this causes the birth of SGA infants. Furthermore, the prothrombin time values become one of the parameters used in forecasting an SGA infant's birth, and this should to be considered as a new fibrinolytic therapy for SGA infants.

Blood Coagulation↗
PubMed1985

Cystic dysplastic kidneys associated with Dandy-Walker malformation and congenital hepatic fibrosis. Report of two cases.

The combined abnormalities of Dandy-Walker malformation, congenital hepatic fibrosis, and generalized cystic dysplastic kidneys were found in two sanguineously unrelated premature babies. This type of cerebrohepatorenal malformation is certainly unique and is generally diagnosed based on the characteristic renal lesion. Remarkably, similar renal lesions have been found in Meckel's syndrome, Goldston's syndrome, and Miranda's syndrome. The present cases can be distinguished from Meckel's syndrome on the basis of the presence of Dandy-Walker malformation and the absence of polydactyly and occipital meningoencephalocele. Although the authors' cases resemble the latter two syndromes in terms of the presence of Dandy-Walker malformation, it is tentatively considered that the distinct triads found in the present cases could represent a new variant of a multiple malformation syndrome with generalized cystic dysplastic kidneys. The etiology of these cases remains unclear, but a genetic factor, which has been suggested as for other syndromes, might be involved.

Abnormalities, Multiple↗
PubMed1985

A serial section study of nuclear pockets containing nuclear material.

A serial section study of leukaemic lymphocytes was carried out to elucidate the three dimensional morphology of nuclear pockets containing nuclear material and their mode of genesis. From this and a previous study on nuclear pockets containing cytoplasmic material we conclude that these are two distinct lesions each with its own mode of genesis and one does not evolve from the other. Hence we propose that the common nuclear pocket containing cytoplasmic material be designated 'type I nuclear pocket' and the nuclear pocket containing nuclear material as the 'type 2 nuclear pocket'. Our serial section study also showed that some type 2 nuclear pockets are open, (i.e. there is continuity between the material in the pocket and the contents of the nucleus) while others are closed (i.e. the material in the pocket is completely separated from the material in the nucleus). At times one sees profiles suggesting that small satellite nuclei occur in leukaemic cells. Our serial section studies show that such profiles can be produced by fortuitous sections through type 2 nuclear pockets.

Cell Nucleus↗