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Biomedical subjects

Y Fuse

Publications and source records attributed to Y Fuse.

At least 127 records · Page 7Linked to original sources
PubMed1985

[Blood coagulation and fibrinolysis in cord blood with reference to birth weight].

To clarify the hemocoagulative and fibrinolytic dynamics of the perinatal period and also to seek the cause of SGA (small for gestational age) baby birth, the coagulation and fibrinolysis of the cord blood were examined, and moreover a comparison with the maternal blood, discussion on the difference in birth weight, and an examination of the difference due to the sex of babies were made in 68 cases with full-term, vaginal, spontaneous delivery, and the following conclusions were reached. In comparison with maternal blood, cord blood significantly showed any of the following: Prolongations of the prothrombin time, and the activated partial thromboplastin time, a decrease in fibrinogen, and a decrease in the platelet aggregation, antithrombin III, and plasminogen. In addition, high values for thromboxane B2 and 6-ketoprostaglandin F1 alpha were observed. In the SGA group, significant decreases were observed in the platelet count, antithrombin III, plasminogen, and alpha 2-plasmin inhibitor as compared with the AGA (appropriate for gestational age) and LGA (large for gestational age) baby groups. No sex difference was observed in the hemocoagulative and fibrinolytic capacities of the cord blood. These hemocoagulative and fibrinolytic capacities, particularly changes in the fibrinolytic system observed in the SGA group, seem to be attributable to chronic DIC (disseminated intravascular coagulation) and mild acidosis due to various stresses during pregnancy and at parturition, in turn due to immaturity of the liver in babies.

Birth Weight↗
PubMed1984

[Blood coagulation and fibrinolysis in spontaneous delivery].

Differences in blood coagulating and fibrinolytic abilities before and after delivery were investigated in order to elucidate the changes occurring at the delivery time in increased blood coagulation and inhibited fibrinolytic condition during pregnancy, especially in its latter period, and the relation between the amount of intrapartum hemorrhage and blood coagulating and fibrinolysis before delivery was examined in order to predict hemorrhage. Twenty-one women who had no complications in pregnancy or delivery and gave birth by vaginal spontaneous delivery with not more than 500ml of intrapartum hemorrhage (normal hemorrhage group) and 7 women who gave birth by vaginal spontaneous delivery with not less than 501ml of abnormal intrapartum hemorrhage (abnormal hemorrhage group) were used as the objects of study, and coagulating and fibrinolytic abilities were examined. The result obtained are summarized as follows: Differences in blood coagulating and fibrinolytic abilities before and after delivery tended to be similar in both normal and abnormal hemorrhage groups. Platelet count and fibrinogen content were decreased, activated partial thromboplastin time became shorter, compared with those examined before delivery, and these appeared to be an increase in blood coagulating ability after delivery. Fibrinolytic ability was seen to be not remarkably different before and after delivery. Fibrinolytic ability was seen to be not remarkably different before and after delivery. Platelet ADP and epinephrine aggregation were reduced after delivery, but platelet collagen aggregation showed no change. As for blood coagulating and fibrinolytic abilities before delivery, prothrombin time was shorter in the abnormal hemorrhage group than in the normal hemorrhage group.(ABSTRACT TRUNCATED AT 250 WORDS)

Blood Coagulation↗
PubMed1984

A serial section study of nuclear pockets and loops.

A serial section study of nuclear pockets in a lymphoma of the stomach showed that: 1) no tumour cell nucleus was free of pockets; 2) approximately 10 to 50 pockets occur on a nucleus; and 3) the pockets show a focal rather than a diffuse distribution on the nucleus. In most pockets cytoplasmic material is completely sequestrated and no channel of communication remains between the cytoplasm and the contents of the pocket. While most pockets contain cytoplasmic material, a few contain nuclear material. It would appear that these are two distinct and different lesions and that one does not evolve from the other. A serial section study of the so-called 'chromatin loops' shows that they are no more than fortuitous sections through pockets. The idea that 'chromatin loops' are cast off from the nucleus receives no support from our studies.

Cell Nucleus↗
PubMed1983

[Immunochemotherapy with tegafur and schizophyllan for stomach cancer--report of 2 cases].

Two cases of gastric cancer were treated with immunochemotherapy using Tegafur and Schizophyllan. In one case, a marked reduction in the size of metastatic liver tumor and disappearance of most subjective symptoms were observed. The response continued even 8 months after the initial treatment. In the other case, no marked symptoms except occasional dysphagis have been noted for 2 years and 2 months since diagnosis, although the primary tumor size has remained unchanged. Thus, it is presumed that the combined immunochemotherapy regimen may be useful in the treatment of advanced gastric cancer.

Aged↗
PubMed1983

[Case of Borrmann III stomach cancer effectively treated by UFT therapy (co-administration of uracil and futraful)].

Through X-ray and endoscopic examination of stomach, a 77 year-old man, who complained of epigastralgia, he was diagnosed to have Borrmann III type gastric carcinoma on the antrum. The gastric biopsy specimen obtained from the tumor revealed to be well differentiated adenocarcinoma. Since the patient refused receiving surgical treatment, a combined administration of futraful and uracil (UFT therapy) was performed. 4 weeks after receiving UFT therapy, the patient became less aware of subjective symptom and the gastrofiberscopic picture showed smaller mass lesion compared to that of prior to the treatment. 8 weeks later, the tumor was remarkable reducing its size. When compared 14 cases of gastric carcinoma receiving UFT therapy with 26 cases receiving Futraful therapy (FT therapy), the UFT group responded more effectively than the FT group. In the UFT therapy, complete (CR) and partial response (PR) were obtained in 4 of 13 cases of gastric carcinoma with an effective rate of 30.8% according to the response criteria proposed by the Koyama-Saitoh group and with a Karnofsky scale of IA or better in 6 (42.8%) of 14 cases. On the other hand, in the FT therapy CR and PR were obtained in 5 of 26 cases with that of 19.2%, while a Karnofsky scale of IA or better was achieved in 6 (23.1%). As for 3 cases of PR in the UFT therapy the microscopic view of the biopsy specimen from gastric carcinoma showed well differentiated adenocarcinoma, which responded to the UFT therapy remarkably 4-5 weeks after receiving UFT therapy.

Adenocarcinoma↗