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Y L Shao

Publications and source records attributed to Y L Shao.

8 recordsLinked to original sources
PubMed1993

Accelerated rejection of murine cardiac allografts by murine cytomegalovirus-infected recipients. Lack of haplotype specificity.

Clinical studies have revealed a correlation between cytomegalovirus (CMV) infection and acute allograft rejection. Likewise, for a murine model we observed that C3H (H-2k) recipients infected with murine CMV (MCMV) rejected BALB/c (H-2d) cardiac allografts earlier than uninfected recipients (6.9 +/- 0.1 d compared with 8.1 +/- 0.6 d; P < 0.001). It has been hypothesized that MCMV epitopes crossreact with alloantigens and in this manner induce rejection. However, we also demonstrated that MCMV caused accelerated rejection in the reverse combination (C3H heart engrafted to BALB/c recipient; 7.2 +/- 0.3 and 9.4 +/- 0.4 d for infected and control animals, respectively; P < 0.001) and accelerated rejection of grafts of a third, unrelated haplotype (C57Bl/6; H-2b; 8.0 +/- 0.7 d compared with 10.1 +/- 0.6 for infected and control C3H recipients, respectively; P < 0.03). Ultraviolet (UV) inactivation of MCMV before administration to the graft recipient abrogated the ability to induce rapid rejection. Activated T lymphocytes were present in grafts from infected recipients 2 d before control recipients (P < 0.02) and, at the time of graft rejection, were almost exclusively CD8+ for both infected and control recipients. Thus, MCMV accelerated rejection appears not to result from crossreaction between MCMV epitopes and MHC products. The failure of UV-inactivated virus to accelerate rejection and the high proportion of CD8+ T cells recovered from all rejected grafts suggest that the class I pathway of antigen presentation may be important in the induction of early rejection.

Animals↗
PubMed1991

Intraperitoneal sensitization and the transplanted mouse heart.

Intradermal or skin-graft sensitization always results in accelerated rejection of subsequent MHC-disparate mouse heart transplants; intravenous or intrasplenic sensitization almost always results in prolonged survival. The survival time after intraperitoneal sensitization is unpredictable: hyperacute or accelerated rejection, as well as normal or prolonged survival, occurs suggestive of a delicate balance between suppressive and rejecting immune responses. We have observed a positive correlation between transplant survival and the distribution of 51Cr-labeled antigenic cells early after i.v., i.d., i.p., and intrasplenic injection. Label recovery from the viscera was already high 2 hr after i.v. injection, while after i.d. injection virtually all label was still confined to the carcass, even at the end of a 24-hr period. After i.p. injection label recovery varied significantly from mouse to mouse, from very low to a level approximating that seen after i.v. injection. This close correlation suggests that the fate of a subsequent transplant is decided within a few hours after antigen deposition, well before placement of the transplant itself.

Animals↗
PubMed1989

The combined tests of overnight 12-hour urine E3/C ratio and fetal heart rate in perinatal monitoring.

Using perinatal monitoring, we evaluated retrospectively 793 late pregnancies with regard to the overnight 12-hour urine estriol/creatinine ratio (E3/C) and fetal heart rate (FHR). The results revealed that 1) FHR corrected the false positive rate of E3/C by 13.7% (93/677); 2) E3/C gave reliable results in perinatal prediction in 81 of the 116 suspicious FHR cases (70%, 81/116); 3) When both tests were abnormal the incidence of poor perinatal results increased by 83.7% (36/43), and the perinatal mortality (7%, 3/43) in patients with abnormal values in both methods was 35 times higher than that in patients with normal results in both tests (0.2%, 1/462); 4) Both negative FHR test and normal E3/C could be reassured, as the risk of death in uterus within a week of both normal tests was only 0.13% (1/793). It is suggested that the E3/C may be used as a first line test for perinatal monitoring, where E3/C value is lower than normal, FHR test is added to increase the reliability of perinatal diagnosis, especially in the moderate and severe hypertensive disorders of pregnancy.

Creatinine↗