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Biomedical subjects

Y Somekawa

Publications and source records attributed to Y Somekawa.

26 records · Page 2Linked to original sources
PubMed1985

Cytological study and chemotactic activity in middle ear effusion.

A cellular analysis of 330 middle ear effusions (MEEs) from children with otitis media with effusion (OME) was performed with the use of cytocentrifuge prepared smears and the results were compared with their clinical data. Chemotactic activity in MEE was also determined with the use of agarose assay and compared with their cytological results. In the acute group the cellular pattern of MEE was mainly the neutrophil dominant type which was observed in 60% of this group. In the chronic group the percentage of this type of MEE decreased but was still present in 25% of them. High chemotactic activity was frequently observed especially in neutrophil dominant type MEE.

Adolescent↗
PubMed1982

Indications for the use of ventilating tubes for secretory otitis media.

Seventy-seven children (147 ears) with secretory otitis media (S.O.M.) were surgically treated by myringotomy with aspiration, insertion of ventilating tubes, and adenoidectomy, if indicated. The results of treatment for S.O.M. were analyzed according to the degree of mastoid pneumatization and complications with or without ipsilateral sinusitis. The present study was performed in order to establish indications for the use of ventilating tubes. The results of treatment for S.O.M. in poorly developed mastoids were poor. With an ipsilateral sinusitis the prognosis of S.O.M. was also poor. In some cases of S.O.M., particularly those in well-developed mastoids, either adenoidectomy alone or myringotomy with aspiration alone proved effective for recovery from middle ear effusions. Ventilating tubes are most suitable for the following conditions: (1) in cases of sclerotic or poorly developed mastoids; (2) in cases with ipsilateral sinusitis; and (3) in cases with recurrent effusions after a first myringotomy with aspiration.

Adolescent↗
PubMedDate not supplied

Spontaneous DNA synthesis in adenoidal lymphocytes from healthy children and from children with otitis media with effusion.

Spontaneous DNA synthesis (SDS) in adenoidal lymphocytes was investigated in 37 children with particular attention to the relationship between the adenoids and otitis media with effusion (OME). The SDS was measured by [3H]thymidine incorporation under a certain culture condition without any mitogens. Adenoidal lymphocytes showed an extremely higher uptake of [3H]thymidine than did peripheral lymphocytes. SDS in adenoidal lymphocytes was much greater in the 3-5-year-old age group than in the older groups. SDS in patients with OME was also significantly greater than that in patients with no complications. Patients who recovered from OME within 3 months following adenoidectomy showed significantly greater SDS than those with recurrent effusion over 6 months. These results might indicate a relationship between the adenoids and OME.

Adenoidectomy↗
PubMedDate not supplied

Immunologic and cytologic studies in otitis media with effusion.

Detection of immune complexes (ICs) of IgG, IgM, or IgA isotypes in middle ear effusions (MEEs) by the solid-phase anti-C3 ELISA and cytologic analyses of MEEs were done in 245 patients with otitis media with effusion (OME). In 320 ears, the clinical classification was acute, 10.3%; subacute, 16.6%; chronic, 73.1%. In the cytologic analyses, the predominant types in each clinical stage were as follows: neutrophil dominant (N) type (63%) in acute cases; neutrophils and lymphocytic (Mixed) type (37%) in subacute cases; and cellular remnant (CR) type (37.8%) in chronic cases. In all the clinical stages IgG-ICs were positive in over 50% of cases and acute cases showed the highest positive rate (64%). IgA)ICs were found in all clinical stages and the highest positive rate was found in subacute cases (67%). In chronic cases, MEEs of N type showed the highest IgG-ICs level and positive rate (75%). These results suggested that immune complexes formed in the middle ear cavity might play an important role in the prolonged inflammatory process of OME through the complement activation following chemotaxis of neutrophils.

Enzyme-Linked Immunosorbent Assay↗