Tissue array technique for p53 expression in human ovarian neoplasms.
OBJECTIVE: To investigate the expression of p53 in human ovarian neoplasms by tissue array technique. METHODS: The expression of p53 protein in various ovarian tissues was studied by tissue array and immunohistochemistry. RESULTS: The expression rate of p53 was 33% in ovarian cancers. There were no expressions in normal ovarian tissues, benign ovarian neoplasms and borderline ovarian neoplasms (P < 0.005). p53 expression was not associated with age of patients and grade of differentiation (P > 0.05) while p53 expression was associated with tissue types (P < 0.05). CONCLUSION: The expression rates of p53 in ovarian cancers were obviously increased.
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