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Biomedical subjects

Z Demel

Publications and source records attributed to Z Demel.

At least 19 recordsLinked to original sources
PubMed1996

Prevention of indomethacin-induced acute gastric mucosal injury by spermine in the rat.

The effect of spermine tetrahydrochloride was investigated on the indomethacin-induced acute mucosal injury and mucosal lipid peroxidation in rats. Spermine was given orally at doses of 25, 75 and 150 mg/kg and, intraperitoneally at 10, 25 and 50 mg/kg 1 hour before 25 mg/kg indomethacin administration. Macroscopic injury was measured by the use of a stereomicroscope. Mucosal malondialdehyde (MDA) levels were determined by an HPLC method. Oral spermine reduced dose-dependently the extent of macroscopic injury from 22.87 +/- 2.88 mm to 11.8 +/- 2.48 mm (p < 0.01, 25 mg/kg), 6.53 +/- 4.19 mm (p < 0.0007, 75 mg/kg) and 0.25 +/- 0.25 mm (p < 0.0001,150 mg/kg). Intraperitoneally administered spermine prevented dose-dependently the indomethacin produced lesions from 19.25 +/- 4.31 mm to 12.63 +/- 3.18 mm (p < 0.01, 25 mg/kg) and to 0.33 +/- 0.33 mm (p < 0.001, 50 mg/kg). Doses necessary for intraperitoneal protection were lower than those achieving similar effect, orally suggesting different mechanisms of action. Neither oral or intraperitoneal spermine influenced the mucosal MDA levels.

Acute Disease↗
PubMed1989

[Immunohistochemical and immunologic changes in aponeurosis in Dupuytren's disease].

Authors examined the aponeurosis of 23 patients with Dupuytren's contracture and of 5, formerly healthy persons, who died in consequence of accidents. It was found that the IgA and IgM content of the palmar aponeurosis is significantly elevated in Dupuytren's disease. The distribution of the immunglobulin containing cells and the fibronection localisation of the aponeurosis was also examined. On the basis of their examinations they think that the autoimmun mechanism may have a role in the development of Dupuytren's disease.

Dupuytren Contracture↗
PubMed1986

Patellar chondropathy. II. Ultrastructure, scanning electron microscopic studies.

A scanning electron microscopic study of the chondropathy of the patellar articular surfaces following knee injury was made. The early signs of degeneration were evident in the superficial membrane. Here, the fibres running parallel with the surface then turning deep become irregularly arranged, i.e. the amount of matrix embedding the fibres was reduced and the uncovered fibres became fragmented causing degeneration of the superficial membrane. During the progressive pathological process, as a result of the gradual deterioration of the interterritorial substance of the uncovered hyaline cartilage, spaces, fissures and deep pits were formed in the upper, then the lower, articular layers. The degeneration involved also the chondrons. With the disintegration of the chondrons the external and internal cell areolae disappear, the cell nests of chondrocytes are opened and the cells degenerate. Finally, the irregular cellular and fibrous structures and their remnants as well as the elements of connective tissue proliferation initially associated with the degenerative process can be visualized ultrastructurally.

Cartilage Diseases↗
PubMed1985

Recapillarization of tenotomized skeletal muscles after delayed tendon suture. I. Experimental study.

The investigation was under taken to study the long-term effect of tendon suturing on the capillarization of guinea-pig crural muscle after Achilles tenotomy. The results indicate that the capillary density has been greatly decreased by the tenotomy. The recapillarization and the time of restitution of the crural muscle are influenced by the interval between tenotomy and tendon suture.

Adenosine Triphosphatases↗
PubMed1985

Analysis of skeletal muscle capillarization: methodological problems.

Capillarization of skeletal muscle has been studied on the same muscle with different methods. Capillary/muscle fibre ratio, number of muscle fibres in contact with capillaries, capillary density in a unit area, capillary density on the muscle fibre surface were determined. The various methods gave different numerical data. Determination of capillary/muscle fibre ratio seemed to be the most reliable index of the changes in pathological conditions.

Animals↗
PubMed1984

Fine structural alterations of collagen fibers in degenerative tendinopathy.

Fine structural alterations of collagen fibers were analyzed in 29 ruptured tendons. The most frequent alterations were longitudinal splitting, disintegration, angulation, and the so-called "Knickdeformation" of the collagen fibers. All these phenomena were considered to be the consequences of stress fatigue and mechanical injuries of fibers.

Adult↗