Biomedical subjects

Z Lević

Publications and source records attributed to Z Lević.

At least 19 recordsLinked to original sources

PubMed1991

Tooth pulp evoked potentials (TPEPs) in multiple sclerosis patients.

The purpose of this study was to determine possible changes of the tooth pulp evoked potentials in patients with multiple sclerosis, and to compare these with other types of evoked potentials, in the same patients. The results showed TPEP changes in all multiple sclerosis patients. In 12 patients the changes were observed on both sides, while in 6 on one side only. It is interesting to note that the second negative wave was characterized by two peaks. The first peak possessed latency of approximately 125 ms that was significantly shorter than in the control group. The second peak appeared after about 195 ms. The significant prolonged latency of the second negative wave was observed in 100% of TPEPs, 95% VEPs and 72% AEPs. In only one case the changes were observed in TPEPs, while VEPs and AEPs were normal. It could be concluded that TPEPs, as well as other types of evoked potentials, are a sensitive indicator of the demyelination process.

Adolescent↗

PubMed1991

Single dose and steady state pharmacokinetics of valproic acid in adult epileptic patients.

The pharmacokinetics of valproic acid was studied in ten adult epileptic patients (five f + five m, 19-48 years; 28 +/- 12, mean +/- SD, and body mass 45 to 70 kg; 61 +/- 7, mean +/- SD) both after single dose and at the steady state. Sodium valproate was given in a 900 mg single oral dose on the first day of therapy, followed by 3 x 300 mg/day during the three subsequent days (at the intervals of 7, 8 and 9 h). During the first day, plasma was obtained just before the drug was given, and at 0.5, 1, 2, 3, 4, 5, 6, 8, 10 and 12 h after drug administration. On the fourth day of therapy (at steady state), plasma was obtained just before the next dose and 3 h after the drug administration. The plasma concentrations of valproic acid were measured by gas chromatography with flame ionization detection, after extraction with chloroform. The pharmacokinetic parameters, necessary to define the pharmacokinetics of valproic acid, were calculated both after single dose: Cmax, tmax, kel, t1/2, Vd, AUC and Cl, and at steady state: Cminss Cmaxss and Fl%. These parameters, as well as plasma levels of the drug, were used to describe the pharmacokinetic behaviour of valproic acid under these clinical conditions, and mainly were in agreement with the values published in the literature.

Administration, Oral↗

PubMed1990

The disturbance of nonverbal functions in dysphasia.

Various modalities of six neuropsychological functions (graphia, calculia, finger gnosis, right-left orientation, praxia and constructive praxia) referred to as parietal or nonverbal have been investigated in the light of speech disorders. We examined 20 patients with brain lesion of vascular origin, who met the diagnostic criteria of mild and moderate dysphagia, 13 patients with Wernicke's and 7 with Broca's dysphasia. Verbal and nonverbal functions in patients with ischemic focuses of the speech area of the left hemisphere were investigated the Boston Diagnostic Aphasia Examination (BDAE). The investigation revealed that the presence and the type of mild and moderate dysphasia had a noteworthy role in pathoplasticity of correlated signs, thus implying in clinical practice a parietal lesion. Generally, poorer and at the same time more heterogeneous results were obtained in patients with Wernicke's dysphasia, mostly on calculia and right-left orientation. Finger agnosia was not considered as an authentic parietal sign, while each modality of graphia was impaired to a varying extent in speech disorders caused by presylvian and retrosylvian lesions. The paper also deals with the significance of lobulus parietalis inferior in speech.

Aphasia↗

PubMed1990

Circulating autoantibodies in multiple sclerosis.

By using indirect immunofluorescence method, we analyzed the presence of antinuclear, anticardiac, microsomal, parietal-cell, smooth-muscle and mitochondrial antibodies in sera of 33 patients with definite multiple sclerosis (MS), without clinical evidence of associated autoimmune disorder, and 14 patients with other neurological disorders (OND). In MS patients, the prevalence of both organ-specific and non-organ-specific antibodies was significantly higher (p less than 0.05) than in OND patients. In both groups, the titers of circulating antibodies were low. The presence of low levels of autoantibodies in sera of MS patients might be the result of immunodysregulation in MS.

Adult↗

PubMed1989

Psychiatric disorders associated with corticosteroid therapy.

Psychiatric disorders accompanying corticosteroid therapy are reported. They are much more frequently encountered than is generally believed. Moreover, they seem to correlate with the dosage applied. For more convenient clinical approach, we suggest classification of the disorders into four groups. The authors report two of their cases suffering from multiple sclerosis with associated steroid-induced psychosis. Besides the review of etiological mechanisms, the approach to treatment of psychiatric complications induced by steroid therapy is also suggested.

Adrenocorticotropic Hormone↗

PubMed1987