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Biomedical subjects

Z M Kiseleva

Publications and source records attributed to Z M Kiseleva.

At least 19 recordsLinked to original sources
PubMed2005

[The soluble fibrin monomer in patients with instable angina].

The purpose of the study was to measure the blood level of thrombus precursor protein (TpP), a soluble fibrin monomer, in patients with stable exertional angina (SEA) and healthy people. The study included the examination of 33 patients with SEA (functional class II and III) and 29 practically healthy volunteers (control group). The detection of TpP in blood plasma was performed by solid-phase immune-enzyme analysis ("sandwich" type) using commercial diagnosticum "Kit" ("ABS", USA) and a microplate reader "IEMS Analyzer\Dispenser, with automatic result calculation in "Logistic fif" mode. TpP level in patients with SEA on the average was slightly higher than in control group, but the difference was not significant. TpP blood level was independent of the patients' gender, age, angina functional class and an old myocardial infarction. TpP blood level in patients with SEA depended on the duration of the illness, and proved to be significantly higher (compared with that in control group) in patients with SEA during the first 5 years of the illness, i.e. at early stages of CHD. Solid-phase immune-enzyme analysis ("sandwich" type) is a highly informative and affordable clinical method. TpP level in patients with SEA on the average was slightly higher than in healthy people (1.21 +/- 0.06 mkg/ml and 1.01 +/- 0.12 mkg/ml, respectively), but the difference was significant only in patients during the first 5 years of having SEA (1.41 +/- 0.11 mkg/ml).

Adult↗
PubMed1992

[Effect of emotional stress on catecholamine and dopa levels in some central nervous regions and in the heart of experimental animals].

The paper presents the results of examining the levels of dopamine, norepinephrine, epinephrine and precursors of their DOPA biosynthesis in the hypothalamus, hypophysis, medulla oblongata, adrenals and heart in miniature pigs exposed to acute stress. The acute emotional stress was shown to be characterized by a significant increase in the activity of the brain hypothalamic region, adrenals, peripheral portion of the sympathoadrenal system, as evidenced by higher norepinephrine release and hence lower neurotransmitter levels in the above structures. This resulted in abnormal physiological norepinephrine/epinephrine ratios in the central nervous system and heart, predisposing to myocardial metabolic and electric instability.

Adrenal Glands↗
PubMed1990

[The sympathetic-adrenal system in mitral heart defects in patients of different ages studied by the use of a specific L-DOPA test].

As many as 59 patients aged 35 to 74 years suffering from mitral valvular disease (MVD) were examined for excretion of dopamine (DA), noradrenaline (NA) and adrenaline, parameters indicating the activity of the sympathoadrenal system. Administration of L-DOPA brought about a significant increase of excretion of all catecholamines in all the patients under 59 years and in those aged 60 to 74 years. In patients with stage I and IIA heart failure, DA excretion rose 50-fold in response to L-DOPA administration, in those with stage IIB and III, 17-fold (p less than 0.001). In patients suffering from MVD, no age-associated differences were revealed in the levels of catecholamines and ICM. In patients suffering from MVD with the predominance of stenosis and in those with stage I and IIA heart failure, background excretion of NA was significantly higher than in patients suffering from MVD with the predominance of heart failure (p less than 0.01). Administration of L-DOPA was followed by an appreciable increment of NA exactly in patients suffering from MVD with the predominance of stenosis (p less than 0.001). In the majority of patients with stage III heart failure refractory to multimodality treatment, the L-DOPA test revealed the smallest increment of DA; its excretion rose only 12-fold. Therefore, the progress of heart failure entails a decrease of the reserve potentialities of the sympathoadrenal system, marked by less output of its mediators.

Adrenal Glands↗
PubMed1990

[Clinical value of determining the levels of renin, aldosterone and vasopressin in newborn infants in critical conditions].

The concentrations of aldosterone, vasopressin and plasma renin activity were measured in cord blood and on days 1, 3 and 5 of life in 71 newborn infants from the risk group at the development of critical conditions. Vasopressin was discovered to play a substantial role in the development of critical conditions. The lack of a considerable vasopressin ejection in response to a delivery trouble and the growth of its concentration by day 5 of life are prognostically unfavourable. Hyperactivity of the renin-aldosterone system determines the newborns' proneness to liquid and sodium retention.

Aldosterone↗
PubMed1989

[Evaluation of the excretion of vanilmandelic acid using paper and cellulose acetate electrophoresis].

The authors compare the results of vanillylmandelic acid (VMA) excretion measurements by high-voltage electrophoresis on paper and by microelectrophoresis on cellulose acetate. Transverse scanning of electrophoregrams has been used for quantitative evaluation of the results of microelectrophoregrams on cellulose acetate. The results of VMA excretion measurements by the two methods have been in good correlation: r = 0.93, n = 15, y = 0.17 + 0.78x, p less than 0.01. Electrophoresis on cellulose acetate is three times less labor consuming and can be performed with Soviet equipment and maintenance medium. The excretion intensity can be assessed visually by reference values of VMA concentration.

Electrophoresis↗
PubMed1988

[The heart and catecholamines from the viewpoint of the adaptive-trophic function of the sympathetico-adrenal system].

Basal excretion of DOPA, dopamine, noradrenaline and adrenalin and its variation in response to oral administration of L-DOPA, a catecholamine precursor, were measured in 491 patients with essential hypertension, cardiomyopathy and myocardial infarction to assess catecholamine synthesis reserves at the systemic level. It is suggested that the development and progress of these diseases is associated with initial activation of the system, accompanied by increased noradrenaline release, which is followed by a gradual decrease in mediator synthesis reserves. The physiologic noradrenaline/adrenalin constant hypothesis, based on clinical and experimental evidence, is supported by the results of catecholamine studies in the heart and the central nervous system in cases of sudden human cardiac death, demonstrating an abrupt drop in noradrenaline. A conclusion is made that adaptive-trophic adrenosympathetic function is linked with biochemical events maintaining noradrenaline content within a normal range.

Adaptation, Physiological↗
PubMed1987

[Experimental cardiomyopathy and the sympathetic-adrenal system].

Along with viral-immunological theory of cardiomyopathy development there is also an opinion on a possible role of neurohumoral regulatory disturbances in this process. Cardiomyopathy in ACB rats was induced by immunization of animals with hemolytic streptococci supplemented by 20% myocardial homogenate. The animals developed hypertrophy of all heart compartments. The reduction in dopamine, noradrenaline and adrenaline levels in the myocardium and a rise in DOPA content have been observed. A significant decrease in labelled noradrenaline uptake by the atria and right ventricle was noted. Changes in catecholamine level in the heart and reduced reversed noradrenaline uptake are indicative of an active role of the sympathetic-adrenal system in the mechanisms of cardiomyopathy development.

Adrenal Glands↗
PubMed1983

Left ventricular function, haemodynamics and certain indicators of neurohumoral control during submaximal exercise in patients with essential hypertension.

The study was carried out in 22 men with essential hypertension, stage I B-II B, aged 25 to 46 years, and in 10 healthy volunteers of the same age. The authors investigated indicators of systemic and intracardiac haemodynamics by echocardiography, determined the blood plasma catecholamine concentration, catecholamine excretion, renin and cyclic nucleotides activity in plasma, both at rest and during continuous submaximal graded exercise on a bicycle ergometer. The haemodynamic response to exercise differed in patients with stable HPT from healthy subjects and patients with labile HPT by an increase in diastolic blood pressure, a lesser drop in end-systolic volume and in total peripheral vascular resistance, a lesser rise in cardiac output, and by a substantially higher left ventricular mass. The left ventricular ejection fraction did not rise in patients with stable hypertension. In these patients, no statistically significant concentration of urine catecholamines and their urine excretion was observed, in contrast to the other two groups where these indicators were increased. A negative correlation was found between the left ventricular mass and the ejection fraction during exercise, which attests to a negative influence of left ventricular hypertrophy on the pump function of the heart during exercise in patients with essential hypertension.

Adult↗
PubMed1982

[New data on the state of the sympathetic-adrenal system in hypertension].

Levels of catecholamines in blood, excretion of DOPA, dopamine, adrenaline and noradrenaline were determined in 99 hypertensive patients and 22 healthy persons. Walking for an hour and intake of L-DOPA in a dose of 3 mg/kg of body mass were used as functional tests. There was noted an increase in activity and reactivity of the sympathoadrenal system at early stages of the disease with its gradual reduction in the courses of the disease. In all the patients, with the exception of stable hypertensive patients with crisis, there was noted an increase in the biosynthesis of dopamine which is considered as a possible compensatory protective mechanism opposing pressor actions. An increase in the biosynthesis of noradrenaline was found at early stages of the disease in people with hyperreactivity and, in particular, in hypertension with crisis. Stable hypertension was characterized by the tendency to a decrease in the biosynthesis of noradrenaline, more expressed in patients with crisis.

Adrenal Glands↗
PubMed1982

[Endogenous catecholamines and heart function in stimulation of the accelerator nerve].

The role of catecholamines in realization of the effects of the augmenting cardiac nerve has been studied during acute experiments on dogs anesthesized with hexenal. Activation of pump function and myocardial contractility during nerve stimulation has been shown to be in good agreement with the increased noradrenaline concentration in the coronary sinus blood. The synthesis of adrenaline has not been found to lag behind its consumption upon the exposure described. Nerve stimulation has led to accumulation of myocardial adrenaline which takes part in realization of a positive inotropic effect to a far less extent than noradrenaline, and exerts no adverse action on cardiac function.

Animals↗
PubMed1980

[Hypothalamic characteristics in sudden human cardiac death].

The hypothalamus was examined in cases of sudden heart death in 50 persons of both sexes whose ages ranged from 25 to 55. The microscopic and biochemical findings were compared with those in cases of heart death which had not occurred suddenly in patients with myocardial infarction of different duration (50 cases). It is shown that in sudden heart death diffuse edema of the white matter and dystonic changes in the microcirculation vessels develop in the hypothalamus. Biochemical examination discloses in the tissue of the hypothalamus in such cases a sharp decrease in the content of noradrenalin and the precursor of catecholamine synthesis DOPA and a marked increase in the level of adrenalin. It is assumed that there is a causative connection between vascular dystonia and the decrease in the noradrenalin level. An increase in the adrenalin content may be conducive to the intensification of cerebral hydrophilism.

Adult↗