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Biomedical subjects

Z M Kiseleva

Publications and source records attributed to Z M Kiseleva.

At least 37 records · Page 2Linked to original sources
PubMed1979

[Administration of the catecholamine precursor, L-DOPA, for evaluating their in vivo biosynthesis in hypertension].

The activity of the sympathetico-adrenal system was studied in 19 healthy individuals and in 40 patients with grade IB and IIA hypertensive disease. The excretion of free and conjugated forms of catetcholamines (adrenalin, noradrenalin and dopamine) and the precursor of their synthesis DOPA was determined. Comparison of these values in the control period and after per os administration of L-DOPA (levodopa) showed that administration of the precursor makes it possible to appraise catecholamine biosynthesis in vivo on the level of the intact organism. The results indicate that in patients with hypertensive disease of the early stages the production of dopamine is increased, whereas that of noradrenaline is reduced.

Administration, Oral↗
PubMed1977

Catecholamine content of the lacrimal fluid of healthy people and glaucoma patients.

The level of catecholamines was determined in the lacrimal fluid since it may serve as an index of the activity of the sympatho-adrenal system. 86 persons aged between 35 and 65 years were studied. Of these, 49 were glaucoma patients, 16 patients had preglaucoma, and 21 practically healthy subjects served as a control. The results of the study showed that dopa and catecholamines: dopamine, noradrenaline and adrenaline can be determined in the lacrimal fluid of healthy people. Preglaucoma patients were found to have a reduced level of dopamine and its precursor dopa. Glaucoma patients were found to have reduced levels of dopa and noradrenaline. Determination of the level of catecholamine and dopa is considered to be an immediate index of the state of the sympathoadrenal system in the initial glaucoma. Determination of catecholamines and dopa in the lacrimal fluid can serve as a test in glaucoma diagnosis.

Adult↗
PubMed1977

[Various humoral pressor and depressor systems in hypertension].

Study of the hormone content and enzyme activity in patients with hypertensive disease at rest and in various types of stimulation revealed predominance of pressor humoral systems over depressor ones. With the development of the disease, the reaction of these humoral systems to stimulation diminishes. Decrease of the renin-angiotensin-aldosterone system compensatory reaction and the prostaglandin F level in patients with stable, high arterial pressur in response to furosemide administration may be among the causes of the hypotensive and natriuretic effect of this preparation. Activization of the humoral depressor systems in the initial stage of the disease is conducive to the preservation of the water-electrolyte hemostasis in the organism and maintains the labile level of arterial pressure despite the increased activity of the natrium-retaining hormones. Exhaustion of the humoral depressor systems may be one of the causes of arterial pressure stabilization.

Adolescent↗