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Biomedical subjects

Z N Zakov

Publications and source records attributed to Z N Zakov.

At least 37 records · Page 2Linked to original sources
PubMed1986

Cutaneous malignant melanoma metastatic to the vitreous.

A 38-year-old man previously had a cutaneous malignant melanoma excised from his right shoulder. He presented to our clinic with neovascular glaucoma, corneal edema, large pigmented keratic precipitates, anterior chamber reaction, and pigmented aggregates in the vitreous of his left eye. There were no other ocular findings. Subsequent enucleation was performed and the globe was studied histopathologically. Special stains and electron microscopy showed the presence of both macrophages and malignant melanin-producing cells within the vitreous. The diagnosis of cutaneous malignant melanoma metastatic to the vitreous was made based on these findings. This is a rarely reported clinical entity, for which a high index of suspicion should be maintained.

Adult↗
PubMed1985

Multiple recurrent serosanguineous retinal pigment epithelial detachments in black women.

Three middle-aged black women suffered recurrent, multiple, bilateral, asymmetric, serosanguineous retinal pigment epithelial detachments. These involved the posterior fundus with resolution and recurrences producing subretinal hemorrhages, vitreous hemorrhages, retinal pigment epithelial pigmentary mottling, and chorioretinal scars. Fluorescein angiography showed evidence of choroidal neovascular membranes, choroidal serosanguineous leaks, or both. Ocular inflammation was not evident. Systemic laboratory tests were noncontributory. The clinical pattern was not characteristic of any other entity producing serosanguineous retinal pigment epithelial detachments. The origin remains to be defined.

Black People↗
PubMed1984

The acute retinal necrosis syndrome. Possible herpes simplex retinitis.

The acute retinal necrosis (ARN) syndrome is a severe necrotic peripheral retinitis with vasculitis and vitritis. It attacks healthy people and carries a poor visual prognosis. Five patients with ARN were seen. Two showed interesting clinical features. One patient developed the ARN syndrome in both eyes but with a 14-year hiatus separating the two episodes, each being preceded by an infectious illness. A second patient had a possible recurrence of the ARN syndrome in the same eye, one year after the original episode. Each episode was preceded by an upper respiratory infection and ipsilateral vesicular skin lesions on the face. Biopsy of one lesion yielded herpes simplex virus (HSV) in culture. These associations, although not definitive, do lend support to the hypothesis that HSV may be the cause of the ARN syndrome.

Acute Disease↗
PubMed1984

Combined malignant lymphoma of the eye and CNS (reticulum-cell sarcoma). Report of three cases.

Three cases of histopathologically proven combined ocular and central nervous system (CNS) malignant lymphoma (reticulum-cell sarcoma) are presented. A review of the literature revealed 33 cases described with this syndrome. Symptoms and signs of both CNS and ocular disease are discussed. The results of computerized tomography and angiography are also reviewed. The diagnosis has been made by craniotomy, cerebrospinal fluid cytological examination, and by pars plana vitrectomy. The latter two procedures should probably be attempted prior to considering craniotomy. Reticulum-cell sarcoma of the eye and CNS possibly has a multicentric origin.

Aged↗
PubMed1983

Ultrasonographic mapping of vitreoretinal abnormalities.

We conducted a prospective study of 50 consecutive eyes to determine the accuracy of ultrasonographic mapping of vitreoretinal abnormalities. The 50 eyes, all of which had opaque media, underwent A- and B-scan ultrasonography before undergoing vitrectomy. The location and differentiation of any abnormalities were mapped on a fundus drawing sheet. At the time of vitrectomy, the surgeon independently examined the fundus and recorded his findings on a second drawing sheet. When we compared the two sets of drawings, we found that ultrasonography correctly predicted the position of the retina in 45 of 50 eyes and the presence or absence of macular detachment in 48 of 50 eyes. These two findings are particularly important to the surgeon. Ultrasonography also correctly predicted the presence or absence of posterior vitreous detachment in all 50 eyes, correctly described the exact extents of the retinal detachments in 44 of 50 eyes, and located points of vitreoretinal adhesion in 39 of 50 eyes.

Eye Diseases↗
PubMed1983

Spontaneously regressing retinoblastomas, retinoma, or retinoblastoma group 0.

A 5-year-old boy had a gray, translucent retinal mass containing calcified nodules and surrounded by retinal pigment clumping and atrophy. The eye was enucleated and the patient has remained well for seven years. Microscopic examination disclosed an intraretinal tumor composed of benign-appearing cells in a bed of well-vascularized ground substance with calcific foci. There was surrounding retinal pigment epithelial hyperplasia but no peripheral necrosis or signs of tumor regression. There were no mitoses, cellular pleomorphism, nuclear atypia, rosettes, or other characteristics of malignancy. Tumors with this typical fundus appearance have been termed spontaneously regressing retinoblastoma or retinoma. Although the tumor in this patient was histopathologically benign, it carries the same genetic risk as a retinoblastoma. A better term for this lesion, therefore, is retinoblastoma group 0.

Child, Preschool↗
PubMed1982

Choroidal malignant melanoma with liver metastasis before enucleation.

A case of a relatively small ocular malignant choroidal spindle B-type melanoma showed evidence of metastasis at the time of diagnosis of the initial primary tumor. We believe that, for two reasons, the true incidence of metastatic disease at the time of initial diagnosis of choroidal malignant melanoma is not known incomplete workup at the time of diagnosis, and the high percentage of false-negative results of common tests for detecting metastasis. We believe that all patients with the diagnosis of malignant melanoma should have at least a complete physical examination, liver function tests, liver--spleen scan, bone scan, and chest roentgenogram. If enucleation is performed, it should be done as atraumatically as possible. Some aspects of treatment are controversial. Unfortunately, not enough data regarding malignant melanoma or its metastasis are known to recommended with confidence the best method for treating either condition.

Adult↗
PubMed1981

Sympathetic ophthalmia.

A 29-year-old woman developed severe ocular manifestations of sympathetic ophthalmia on the day after enucleation of a blind, painful eye, and four weeks after a penetrating ocular injury. She was observed for one year with fundus photography, fluorescein angiography, and electrophysiologic tests. Nystagmus, a rare systemic manifestation of sympathetic ophthalmia, was noted early in the course of her disease and was accompanied by vertigo, truncal ataxia, and cerebrospinal fluid pleocytosis. Enucleation and intensive corticosteroid treatment resolved the process; however, she has experienced recurrences in the two-year follow-up period.

Adrenal Cortex Hormones↗