Biomedical subjects
Publications and source records attributed to Z N Zakov.
A 40-year-old woman took oral contraceptives for four years. She developed a vascular glaucoma and one year later the eye was enucleated. No other apparent cause for the occlusion was present. The vascular occlusion consisted of a combined central retinal artery and vein occlusion with severe intimal hyperplasia. An intravascular granulomatous reaction is attributed to chronic vascular injury.
Histologic study of eyes used as donor material for corneal transplant revealed one instance of massive leukemic infiltration with leukemic keratic precipitates on the fellow eye. In another eye, microabscesses composed of acute and chronic inflammatory cells containing Crytococcus neoformans were present. In a third patient metastatic anaplastic cells were present in the choroid. We think donor eyes are absolutely unacceptable if death was caused by any chronic neurologic disorder, unless clearly secondary to trauma. Eyes from patients with septecimia, hepatitis, jaundice and any evidence of any active viral infection, syphilis, and positive serology are also unacceptable. Extreme caution should be used in selecting eyes of patients with ocular or systemic malignancy, long-term diseases, particularly if immunosuppressive agents were used, where a history of eye disease exists, including corneal disease or dystrophy, iritis, absolute glaucoma or acute glaucoma, and eyes with a history of previous intraocular surgery.
Explore the source record for details and available documents.
In five patients a 0.0625% concentration of pilocarpine provided the marked difference in miosis between Adie's and normal pupils. Other concentrations did not produce as much as a difference.
The differential diagnosis of leukocoria (pseudoglioma) in the neonate includes multiple conditions, including malformations with retinal dysplasia as a component. Typically bilateral, retinal dysplasia is characteristically seen in microphthalmic eyes. Certain chromosomal defects have been described. The case reported herein presented in the first month of life with an enlarged eye, elevated intraocular pressure, prominent iris vasculature, and leukocoria. Family history was positive in one respect: this is the second child of a Viet Nam veteran exposed to Agent Orange. The first child, from a different mother, also had birth defects. Other than his left eye, the child is completely normal. Ultrasonography showed posterior vitreous opacities of indeterminate configuration. CT scan suggested a posterior intraocular mass. Histologically, the principal features were an anomalous, largely unformed corneoscleral angle, intraocular hemorrhage, and retinal dysplasia. Light microscopic studies were performed. The corneoscleral angle revealed an anteriorly inserted iris with an absence of trabecular meshwork and Schlemm's canal. This case is considered unique on the basis of the association of retinal dysplasia with congenital glaucoma and larger-than-normal eye. The significance of reported paternal exposure to Agent Orange in this instance is unknown.
OBJECTIVES: This prospective study examines the effectiveness of the pneumatic buckle procedure (nondrainage scleral buckle with pneumatic retinopexy) for repair of primary rhegmatogenous retinal detachments. METHODS: We studied 58 consecutive patients with primary rhegmatogenous retinal detachments who underwent a pneumatic buckle with air or SF6. The procedures were performed at 2 centers. Retinal reattachment and visual acuity were examined. RESULTS: The single operation reattachment rate for patients undergoing a pneumatic buckle procedure was 95%. Eighty eight percent of patients with macula-on detachment had unchanged or improved final visual acuity. Sixty seven percent of patients with macula-off detachments had a final visual acuity between 20/20 and 20/50. Twenty nine percent had final visual acuity between 20/60 and 20/200. Two patients developed a new retinal hole postoperatively. CONCLUSION: Pneumatic buckle is an effective technique for repair of primary rhegmatogenous retinal detachments caused by breaks in the superior 8 o'clock segment. This technique avoids the complications associated with the drainage portion of the traditional scleral buckle operation and results in a high rate of retinal reattachment and stable or improved visual acuity. The rate of new retinal hole formation in this study is much lower than those reported for pneumatic retinopexy.