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Z Nowak

Publications and source records attributed to Z Nowak.

39 records · Page 3Linked to original sources
PubMedDate not supplied

Effect of a single intravenous dose of verapamil on some immune parameters in duodenal ulcer patients.

The effect of a single intravenous dose of calcium channel blocking agent verapamil (VER) on immune parameters in humans remains uncertain. In this study the effects of VER on lymphocyte subpopulations, interleukin 1 (IL-1) and 2 (IL-2) production in vitro, autologous mixed lymphocyte reaction (AMLR), IL-2 receptor expression (Tac positive cells) and natural killer (NK) cell activity were assessed. The investigations were undertaken on 12 hospitalized men, aged 19-23 years, with small abdominal complaints. None of them had active duodenal ulcer disease, while in the remaining no signs of organic disease were found. VER was given intravenously in a dose of 0.15 mg/kg and examinations were performed on peripheral blood mononuclear cells (PBL) drawn before and 30 and 150 min following VER injection. The single VER dose induced a significant, but transient increase in T, T helper, T suppressor lymphocytes and monocytes, and decrease in IL-1 and IL-2 generation as well as diminished Tac antigen expression. These data provide evidence that calcium channel blockers may transiently disturb immunoregulation.

Adult↗
PubMedDate not supplied

[Effect of aorto-coronary bypass on function of cardiac ventricles as evaluated by non-invasive techniques during a two year observation].

In 1989-1990, 892 patients with ischemic heart disease were treated at the III Department of Cardiology in Katowice-Ochojec. Aortocoronary bypass was performed in 51 (5.7%) of these patients. Thirty five out of these patients were followed-up for 24 months after surgery. They reported to the hospital for evaluation after 3, 6, 12 and 14 months following a discharge. Efficiency of revascularization was checked with physical examination, and non-invasive tests such as electrocardiography, echocardiography and exercise tolerance testing. Diastolic and symbolic functioning of left and right ventricle was assessed separately. All patients suffered from anginal pain before surgery whereas 85% of operated patients were free from pain. No correlation between incomplete revascularization and recurrence of the anginal pain was noted. Surgery produced an increase in exercise tolerance and maximal load. No significant improvement in the right ventricle was seen during a 2-year follow-up. In the group of patients without previous myocardial infarction measured parameters of cardiac ventricles functioning were better than those in patients who had myocardial infarction. Therefore, the former are better candidates to coronary vessels revascularization.

Adult↗