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Biomedical subjects

Z Podolec

Publications and source records attributed to Z Podolec.

10 recordsLinked to original sources
PubMed1999

Pulse nebulization in pneumatic devices.

Aerosols of a physiological salt solution and aqueous solutions of salbutamol, sodium cromoglicate, and dornase alfa were generated in a pneumatic nebulizer and analyzed in a system with controlled humidity of air as a carrier gas. Mass distribution of aerosol particles and yield of generation for pulse nebulization were measured. Pulsation of generation was realized with an attachment maintained by a computer program. Opening times of the valve were in the range 50-800 ms. The results indicate the possibility of improving aerosol particle delivery to the lung using a pulse generation system.

Administration, Inhalation↗
PubMed1979

Central dopamine receptors regulate blood eosinophilia in the rat.

Dopaminergic agents, dopa and apomorphine, affected biphasically the blood eosinophil count in the rat: low doses of the drug elevated, while high doses lowered it. The response to a high dose of dopa was retained in rats pretreated with an inhibitor of dopamine-beta-hydroxylase, U 10, 157, but prevented by a centrally acting dopa decarboxylase inhibitor, NSD 1015. This indicates that the eosinopenia observed after large doses of dopa is due to the action of dopamine formed from the precursor. As intracerebroventricular injections of Ldopa also produce eosinopenia, the central site of dopamine action is indicated. The eosinopenic response to apomorphine was antagonized by a dopamine receptor blocking agent, haloperidol. This indicates that some central dopamine receptors are involved in the regulation of the eosinophil count in circulating blood. The hypophysis seems to play a crucial role in the phenomenon observed, as no eosinopenia was produced by dopa in hypophysectomized rats.

Animals↗
PubMed1977

Impaired responses of growth hormone and blood eosinophils to L-dopa in atopy.

In order to assess whether response to the natural precursor of catecholamines in the nervous system is impaired in atopy, 500 mg L-dopa was administered to 13 atopic patients with bronchial asthma or hay fever and 13 sex-and-age-matched control subjects. The blood eosinophil count and growth hormone (GH) levels were then determined periodically over a 4-h period. The eosinophil count rose significantly 30 and 60 min after L-dopa in healthy subjects, but not in the atopic patients. The mean rise in GH 30 and 60 min after L-dopa was significantly lower in atopic patients as compared with controls. Injection of apomorphine 0.75 mg elicited increase in GH in nine of the 10 control subjects, but only in six of the 11 atopic patients. These results indicate that central dopaminergic stimulation is often impaired in patients with atopy. In testing GH release, atopy should be considered among the causes of failure to respond.

Apomorphine↗
PubMed1976

Central regulation of blood eosinophilia by the beta-adrenergic system in rats.

The effect of isoprenaline and three different beta-adrenergic blocking agents on blood eosinophilia was evaluated in the rat. Eosinopenic effect of isoprenaline was antagonized by intraperitoneal pretreatment with propranolol and by high but not low doses of practolol. Sotalol, a beta-blocker which in contrast to propranolol does not penetrate the blood-brain barrier, did not affect the eosinophil count when injected intraperitoneally, but produced a marked increase in number of circulating eosinophils following intracerebroventricular injection. Intraperitoneal administration of isoprenaline and propranolol as well as intracerebroventricular injection of sotalol did not affect eosinophil count in adrenalectomized or hypophysectomized rats. These results suggest that beta-adrenergic agents regulate the number of circulating eosinophils through a central mechanism and that presence of both hypophysis and adrenal glands is required for this action.

Adrenalectomy↗
PubMedDate not supplied

[A preliminary assessment of the incidence of atopy at a workplace in Cracow].

Skin tests, IgE level and eosinophils percentage were determined in 337 employees of the "Hydrokop" Works in Cracow. These investigations aimed at seeking more specific markers of allergy than anamnesis and skin tests. Allergy was reported by 108 individuals (38%). Some features of atopy were confirmed in 7.5%. Skin tests were positive in 36 individuals and were related to atopy in 55%. IgE levels were 10 IU/ml--greater than 1000 IU/ml with the distribution similar to log-normal. Mean IgE concentration was relatively high (202 IU/ml, in the individuals with confirmed congenital allergy. Percentage of eosinophils exceeded 3% in 39 subjects out of which 17 reported the symptoms of allergy. IgE level and percentage of eosinophils are controversial as the markers of atopy due to the contribution of various non-allergic factors while skin tests correlate well with allergic diseases which were relatively frequent in the examined group.

Adult↗