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Z Wańkowicz

Publications and source records attributed to Z Wańkowicz.

At least 19 recordsLinked to original sources

[Personal experiences in the treatment of peritonitis with a complicated extended program of peritoneal dialysis].

In 37 pts treated with peritoneal dialysis (PD) in years 1980-1990 results of peritonitis (P) treatment were compared between years 1986-90 (cycle II) and years 1980-85 (cycle I). In I cycle 47 episodes of P occurred in 9 of 21 pts treated with PD, and in cycle II 15 episodes of P in 7 of 16 dialysed pts. Treatment of P was as follows: in cycle I, daily standard PD with gentamicin and cephradine added to 2.01 dialysing exchanges; in cycle II, after initial lavage of peritoneum with a few litres of dialysing solution, 1.0 g vancomycin was given iv and continuous PD started using 1.0 litre prolonged exchanges and aminoglycosides added to dialysis solution. Treatment protocol used in cycle II was more effective than the first one: all episodes of P were immediately cured (only 32 of 47 in cycle I), there was only 1 relapse (in cycle I 6/32 cured P), duration of P was shorter (mean 6.5 days/9.8 days in cycle I) and morphological changes of peritoneum were less expressed than in cycle I. Practically important indicator of cure was decline of polynuclear cells in smear of peritoneal effluent sediment (less than 50% of cells). All 9 pts suffering from P in cycle I had to be transferred to HD (43% of all dialysed pts) and only 2 in cycle II (12% of all dialysed pts).

Adult

[Our experience with the diagnosis of peritonitis complicating a long-term program of peritoneal dialysis].

Among 37 patients (pts) with irreversible renal failure treated in years 1980-1990 with chronic peritoneal dialysis there were 18 treated with continuous ambulatory peritoneal dialysis (CAPD) and 19 treated with standard intermittent peritoneal dialysis (SIPD). Mean frequency of peritonitis (P) was 1 episode per 9.0 patients-months. The important symptoms for early diagnosis of P were as follows: cloudiness of peritoneal effluent (PE) and high (more than 50%) percentage of polynuclear cells in the smear of PE sediment. Positive results of PE culture were obtained only in 50% of P episodes in years 1980-1985, mostly in pts treated with CAPD (17/21 pts). In the period of 1986-1990, in pts treated mostly with SIPD (15/16 pts), positive results were obtained in 80% of P. Improvements of bacteriological diagnosis of P, especially in pts treated with CAPD, were discussed. "Prophylactic" cultures of PE were found to be of no value.

Adult

[Effect of intraperitoneal administration of sandoglobulin on peritoneal fluid IgG level in patients treated by standard peritoneal dialysis (SPD)].

In 6 patients (PTS) treated with SPD for 369 patient weeks (ptw) we evaluated the influence of three intraperitoneal SI on the IgG concentration in the PE. The concentration of IgG was checked before, on 1-st, 3-rd day 2-nd and 3-rd week after SI. In the course of the following 229 ptw, we observed three episodes of peritonitis (PN) in two pts, while in the control period of 140 ptw no PN occurred. The concentrations in PE of opsonins (IgG, C3 complement, fibronectin) at the start of SPD shoved enormous individual differences and did not correlate with occurrence of PN in the follow-up. Intraperitoneal SI caused significant increase of IgG in PE, but only to the third day after infusion. Our preliminary results do not confirm the protective effect of intraperitoneal SI on occurrence of PN in SPD patients.

Aged

[Evaluation of various immunologic parameters in patients treated by continuous ambulatory peritoneal dialysis (CAPD)].

The authors investigated some immunologic parameters in 17 patients treated with CAPD during 11.0 +/- 6.8 months. There were no disturbances in humoral immunity. In cell-mediated immunity we observed only skin anergy specially in patients with high peritonitis rate. In this group we observed lower concentration of IgG, C3 complement and fibronectin in peritoneal effluent.

Adult

[Value of phase-contrast microscopy in differential diagnosis of erythrocyturia].

In 41 patients with erythrocyturia the usefulness was assessed of phase-contrast microscopy of erythrocytes in urinary sediment. In all 28 patients with non-glomerular erythrocyturia (less than 20% of changed sediment erythrocytes) non-glomerular, mainly urological, causes of erythrocyturia were found. In 13 cases of glomerulonephritis confirmed by biopsy erythrocyturia was in 6 cases of glomerular character (greater than 60% of changed sediment erythrocytes), in the remaining 7 cases it was of mixed character (greater than 20-60% of changed sediment erythrocytes). In cases of glomerulonephritis a correlation was found between the per cent of changed sediment erythrocytes in this microscopy and the severity of glomerulopathy and the coexistence and intensity of interstitial-tubular changes in renal biopsy. The accepted mode of differential diagnosis of erythrocyturia includes presently renal biopsy in case of glomerular erythrocyturia and undertaking of urological diagnostic procedures in case of non-glomerular erythrocyturia. In case of mixed erythrocyturia the diagnostic procedure is as yet as in non-glomerular erythrocyturia. This will be eventually changed when our experience will increase.

Adolescent

[Effect of erythropoietin on some rheological and biochemical properties of blood in dialysed patients with irreversible kidney failure. Preliminary results].

6 patients with symptomatic renal anaemia treated with haemodialysis (3F, 3M, aged 41 +/- 17 years) were given r-Hu EPO in initial dose of 50 U/kg, modified during the treatment, according to the Hkt, and Hgb values. Some biochemical and rheological properties of blood taken before treatment showed: normochromic and normocytic anemia with Hkt 22.7 +/- 1.7% Hgb 6.81 +/- 1.6 g% and normal reticulocytosis: significant (p less than 0.001) decrease of whole blood viscosity (WBV) at low shear rate (2.25 x sec-1) and high shear rate (225 x sec-1) related to Hkt values, and significant increase of red celles aggregation (RCA) (p less than 0.02) in comparison to healthy persons. Plasma viscosity (PV), serum fibrinogen, protein and albumin were normal. In 4 patients treated with r-Hu EPO for 12 weeks at least, we observed an increase Hkt to 36.7 +/- 2% and Hgb to 11.2 +/- 1.2 g% and a significant increase of WBV at high shear rate (p less than 0.05), normalization of RCA and improvement of the filtrability of whole blood. No side effects were observed, especially insufficient control of blood pressure. Our preliminary results indicate that our treatment of renal anemia with r-Hu EPO was clinically effective, safe and had positive influence on blood rheology.

Adult

[The effect of verapamil on peritoneal dialysis efficiency in a clinical study].

Authors investigated influence of intraperitoneal verapamil on standard peritoneal dialysis efficiency. 18 peritoneal dialyses were performed in 4 patients. Verapamil was used in doses 5 and 10 mg per exchange of peritoneal fluid without a significant influence on ultrafiltration, sodium sieving index, urea and creatinine clearances. At the start of the study all patients had normal peritoneum evaluated with peritoneal scintigraphy using sulphide colloid, glucose equilibrium curve and D/P for creatinine.

Adult

[Effect of hemodialysis fluids with different pH values and buffer types used in peritoneal dialysis on the phagocyte system in the peritoneal cavity. The experimental part].

In a four-hour exchange of dialysing fluid in 120 healthy mice it was checked whether and in what degree changes of the pH of the dialysing fluid in the range from 5.09 to 7.02 and change of the buffer in the dialysing fluid (acetate, lactate) have an effect on the phagocytic and bactericidal ability of the phagocytic cells in the peritoneal dialysate. The study of the count of phagocytic cells, their bactericidal ability (NBT test) and phagocytosis ability (latex test) showed that neither the type of the used buffer nor pH changes of the dialysing fluid in the range 5.09-6.18 had no effect on the defensive properties of the phagocytes in healthy peritoneal cavity. The observation of a statistically significant increase in the proportion of cells of low phagocytic ability in the group of mice receiving acetate buffer of pH 7.02 requires further studies.

Animals

[Ultrasonic changes in organs in the course of poisoning with mushrooms].

A case of the poisoning with mushrooms of severe clinical course is presented. Lesions to parenchymatous organs were diagnosed with ultrasound. The authors stress the value of ultrasound examination in the evaluation of the lesions to internal organs in the course of poisoning and in prognosis.

Child, Preschool

[Selection of the optimal method of evaluation of peritonitis risk in patients treated by standard peritoneal dialysis].

In order to find the optimal method of detecting the impending risk of peritonitis in patients on chronic standard peritoneal dialysis the authors evaluate the following: peritoneal fluid leucocytes total and differential counts (in the samples taken before the first morning infusion of the dialysis fluid into the peritoneal cavity as well as in the first change of the fluid), cultures from the peritoneal fluid and blood CRP before the start of the dialysis. A group of 8 patients was studied. Clinical signs of peritonitis occurred on 6 occasions during the total of 192 dialysis performed. In all those cases the differential count leucocytes was abnormal (more than 50% ofpolynuclear cells) as well in the peritoneal fluid obtained before the start of dialysis as in the first portion of the dialysis fluid. A high percentage (78%) of the false positive results of the total leucocyte count in the pre-dialysis fluid and in the first change of dialysis fluid (29%) as well of the blood CRP (25%) seem to, indicate a low practical value of those methods. The differential count of leucocytes of the sediment of the peritoneal fluid seems to be the optimal method of early detection of the impending peritonitis.

Adult