Biomedical subjects

Z Zaleska-Rutczyńska

Publications and source records attributed to Z Zaleska-Rutczyńska.

5 recordsLinked to original sources

PubMed1976

Influence of the alpha-globulin fraction isolated from calf serum on graft-versus-host reaction in strongly histoincompatible mice.

The influence of a two alpha-globulin fractions isolated from calf serum by the method of Mowbray on the graft-v-host reaction (GVH) in the F1 hybrids of inbred mouse strains differing in H-2 locus after administration of parental lymphatic cells was studied. Some of the mice were X-irradiated with 500 R before administration of parental cells. The studied fractions exerted strong suppressive action on the splenomegalic reaction and proliferative phenomena in the spleen, accompanied by intensification of changes in the liver, particularly in irradiated mice, It was concluded that the applied doses of the investigated preparations had no influence on immunologic actvity of the donor's lymph cells, but that they inhibited nonimmunologic proliferation of recipient cells and consequently impaired defense mechanisms in the F1 hybrids.

Alpha-Globulins↗

PubMed1976

Further studies on the influence of calf alpha-globulin on survival of skin allografts in mice.

A single injection of 10 mg of alpha-globulin fraction isolated from calf serum prolonged survival of skin allografts in mice provided the preparation was injected two days before grafting. An immunosuppressive effect was also obtained by injecting alpha-globulin in a total dose of 13 mg in the second week after grafting in mice pretreated with antithymocyte serum; On the other hand, such an effect was not obtained when alpha-globulin was injected in the early days after grafting in doses of up to 25 mg per mouse.

Alpha-Globulins↗

PubMed1976

Colony forming units (CFU) in bone marrow associated with heterotopic bone formation by epithelial cells grafted in mice.

The presence of bone marrow accompanying heterotopic bone induction in mice did not increase the number of endogenous spleen colonies. However, such bone marrow, as judged by the ability to form exogenous spleen colonies, contains colony-forming cells (CFC). No significant difference was found between the concentration of CFC in the induced and in the femoral bone marrow. This indicates a qualitative similarity between these two types of bone marrow inasfar as hemopoietic activity is concerned.

Animals↗

PubMed1975

Comparison of the role of testosterone and methyltestosterone in developing chloroform-induced renal tubular necrosis in mice.

The presence of testosterone is a prerequisite for the development of chloroform-induced renal tubular necrosis in mice. The purpose of this study was to check whether methyltestosterone exerts the same influence. Castrated males and females were treated with one of these compounds: those treated with testosterone developed renal tubular necrosis after chloroform injection, those which received methyltestosterone were free of this lesion.

Acute Kidney Injury↗

PubMedDate not supplied

Some serum biochemical changes associated with chloroform-induced renal tubular necrosis in mice.

The chloroform--induced renal tubular necrosis is associated with the rise of serum urea, creatinine and potassium. The highest values, observed 24 hours after chloroform administration, are respectively: 75 mg% (norm 32 mg%), 1.75 mg% (norm 0.25 mg%), 6.1 mEq/1 (norm 4.4 mEq/1). They gradually decreased with the progress of renal regeneration. These transient, rather little biochemical deviations justify the good conditions and eventual survival of chloroform-poisoned mice. The contribution of possible glomerular lesions to the disturbed renal function is taken into consideration.

Acute Kidney Injury↗