Influence of the alpha-globulin fraction isolated from calf serum on graft-versus-host reaction in strongly histoincompatible mice.

Abstract

The influence of a two alpha-globulin fractions isolated from calf serum by the method of Mowbray on the graft-v-host reaction (GVH) in the F1 hybrids of inbred mouse strains differing in H-2 locus after administration of parental lymphatic cells was studied. Some of the mice were X-irradiated with 500 R before administration of parental cells. The studied fractions exerted strong suppressive action on the splenomegalic reaction and proliferative phenomena in the spleen, accompanied by intensification of changes in the liver, particularly in irradiated mice, It was concluded that the applied doses of the investigated preparations had no influence on immunologic actvity of the donor's lymph cells, but that they inhibited nonimmunologic proliferation of recipient cells and consequently impaired defense mechanisms in the F1 hybrids.