PubMed · 10069325
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D M Kullmann. 1999. Variable loudness at individual excitatory synapses.. https://doi.org/10.1016/s0896-6273(00)81080-6
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Gap junctions between excitatory neurons are shown to disrupt the persistent state. The asynchronous state of the network loses stability via a Hopf bifurcation and then the active state is destroyed via a homoclinic bifurcation with a stationary state. A partial differential equation (PDE) is developed to analyze the Hopf and the homoclinic bifurcations. The simplified dynamics are compared to a biophysical model where similar behavior is observed. In the low noise case, the dynamics of the PDE is shown to be very complicated and includes possible chaotic behavior. The onset of synchrony is studied by the application of averaging to obtain a simple criterion for destabilization of the asynchronous persistent state.
This study assessed whether changes in size or time-course of excitatory postsynaptic potentials (EPSPs) in motoneurons innervating spastic muscle could induce a greater synaptic response, and thereby contribute to reflex hyperexcitability. We compared motor unit (MU) firing patterns elicited by tendon taps applied to both spastic and contralateral (nonspastic) biceps brachii muscle in hemiparetic stroke subjects. Based on recordings of 115 MUs, significantly shortened EPSP rise times were present on the spastic side, but with no significant differences in estimated EPSP amplitude. These changes may contribute to hyperexcitable reflex responses at short latency, but the EPSP amplitude changes appear insufficient to account for global differences in reflex excitability.
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