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PubMed · 10072882

[Severe combined immunodefficiency disease, 4 autopsy case reports].

P Yan·G Chen·M Zhang
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Abstract

OBJECTIVE: To study the pathological changes of severe combined immunodefficiency disease (SCID). METHODS: 4 cases with SCID proven by autopsy examination. RESULTS: All patients were male with an average age of 5 moths. The major clinical manifestations included severe repeated infection with bacteria, virus, fungi and pneumocystis carinii. Autopsy examination revealed hypoplasia of thymus, spleen and lymph nodes. 1 case died from pneumocystis carinii pneumonia and BCG vaccine disease, 2 cases died of severe general infection and 1 case died from large cell lymphoma. CONCLUSIONS: The main diagnosis criteria for SCID are hypoplasia of both T and B lymphocytes, the pathologic changes of SCID are very complex.

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Cytomegalovirus InfectionsHumansInfantLymphoma, Large B-Cell, DiffuseMalePneumonia, PneumocystisSevere Combined ImmunodeficiencyThymus GlandEnglish AbstractJournal Article

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P Yan, G Chen, M Zhang. 1997. [Severe combined immunodefficiency disease, 4 autopsy case reports].. https://pubmed.ncbi.nlm.nih.gov/10072882/

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