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PubMed · 10084244

Caffeine consumption and menstrual function.

L Fenster·C Quale·K Waller·G C Windham·E P Elkin·N Benowitz·S H Swan
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Abstract

The relation between caffeine intake and menstrual function was examined in 403 healthy premenopausal women who belonged to Kaiser Permanente Medical Care Program in 1990-1991. A telephone interview collected information about caffeinated beverage intake as well as other lifestyle, demographic, occupational, and environmental factors. Subjects collected daily urine samples and completed a daily diary for an average of five menstrual cycles. Metabolites of estrogen and progesterone were measured in the urine, each cycle was characterized as anovulatory or ovulatory, and a probable day of ovulation was selected when appropriate. Logistic regression and repeated measures analyses were performed on menstrual parameters. Women whose caffeine consumption was heavy (>300 mg of caffeine per day) had less than a third of the risk for long menses (> or =8 days) compared with women who did not consume caffeine (adjusted odds ratio = 0.30, 95% confidence interval 0.14-0.66). Those whose caffeine consumption was heavy also had a doubled risk for short cycle length (< or =24 days) (adjusted odds ratio = 2.00, 95% confidence interval 0.98-4.06); this association was also evident in those whose caffeine consumption was heavy who did not smoke (adjusted odds ratio = 2.11, 95% confidence interval 1.03-4.33). Caffeine intake was not strongly related to an increased risk for anovulation, short luteal phase (< or =10 days), long follicular phase (> or =24 days), long cycle (> or =36 days), or measures of within-woman cycle variability.

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AdultCaffeineDose-Response Relationship, DrugEstroneFemaleHumansMenstruationOvulationPregnanediolJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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L Fenster, C Quale, K Waller, G C Windham, E P Elkin, N Benowitz, S H Swan. 1999-03-15. Caffeine consumption and menstrual function.. https://doi.org/10.1093/oxfordjournals.aje.a009851

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