Effects of passive immunization against morphine on heroin self-administration.

A Killian; K Bonese; R M Rothberg; B H Wainer; C R Schuster

doi:10.1016/0091-3057(78)90295-2

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Effects of passive immunization against morphine on heroin self-administration.

A Killian·K Bonese·R M Rothberg·B H Wainer·C R Schuster

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Abstract

Antimorphine antibodies produced in Rhesus monkeys immunized with morphine-6-hemisuccinate-BSA were passively administered to recipient monkeys trained to self-administer heroin and cocaine. Following antibody administration, changes in heroin self-administration behavior were observed which were similar to those achieved with low doses of naloxone. Both manipulations increased heroin self-administration without affecting cocaine responding.

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Animals Cocaine Conditioning, Operant Haplorhini Heroin Heroin Dependence Humans Immune Sera Immunity, Maternally-Acquired Macaca mulatta Morphine Naloxone Self Administration Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

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A Killian, K Bonese, R M Rothberg, B H Wainer, C R Schuster. 1978. Effects of passive immunization against morphine on heroin self-administration.. https://doi.org/10.1016/0091-3057(78)90295-2

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