Newer diagnostic techniques and problems in Cushing's disease.

J W Findling; H Raff

doi:10.1016/s0889-8529(05)70063-3

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PubMed · 10207691

Newer diagnostic techniques and problems in Cushing's disease.

J W Findling·H Raff

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Abstract

The best diagnostic approach to patients with suspected Cushing's disease continues to evolve. The introduction of transsphenoidal pituitary surgery as the treatment of choice for Cushing's disease as well as the absence of any pituitary imaging abnormalities in many patients with Cushing's disease has made accurate diagnosis and differential diagnosis essential. In the authors' opinion, two or three late night (11 PM) salivary cortisol determinations and the measurement of 24-hour UFC are the best and simplest means to evaluate patients with suspected hypercortisolism. L-DST can no longer be recommended to exclude the diagnosis of Cushing's disease, particularly if the hypercortisolism is mild. The combination of L-DST and CRH stimulation is a new and apparently sensitive means to establish the presence or absence of pathologic hypercortisolism in equivocal cases. In the absence of an overt pituitary tumor on MR imaging, inferior petrosal sinus sampling with CRH stimulation should be performed to secure the diagnosis of Cushing's disease as well as identify the probable location of the corticotroph adenoma.

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Adrenocorticotropic Hormone Circadian Rhythm Corticotropin-Releasing Hormone Cushing Syndrome Deamino Arginine Vasopressin Dexamethasone Diagnosis, Differential Glucocorticoids Humans Hydrocortisone Saliva Journal Article Research Support, Non-U.S. Gov't Review

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J W Findling, H Raff. 1999. Newer diagnostic techniques and problems in Cushing's disease.. https://doi.org/10.1016/s0889-8529(05)70063-3

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